RU2000103966A - METHOD FOR PRODUCING FUNCTIONALLY SUBSTITUTED METHYLENE CLICOBUTANE - Google Patents

METHOD FOR PRODUCING FUNCTIONALLY SUBSTITUTED METHYLENE CLICOBUTANE

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Publication number
RU2000103966A
RU2000103966A RU2000103966/04A RU2000103966A RU2000103966A RU 2000103966 A RU2000103966 A RU 2000103966A RU 2000103966/04 A RU2000103966/04 A RU 2000103966/04A RU 2000103966 A RU2000103966 A RU 2000103966A RU 2000103966 A RU2000103966 A RU 2000103966A
Authority
RU
Russia
Prior art keywords
allene
carried out
substituted methylene
functionally substituted
clicobutane
Prior art date
Application number
RU2000103966/04A
Other languages
Russian (ru)
Other versions
RU2174505C1 (en
Inventor
Вадим Алексеевич Меньщиков
Original Assignee
Открытое акционерное общество "Всероссийский научно-исследовательский институт органического синтеза"
Filing date
Publication date
Application filed by Открытое акционерное общество "Всероссийский научно-исследовательский институт органического синтеза" filed Critical Открытое акционерное общество "Всероссийский научно-исследовательский институт органического синтеза"
Priority to RU2000103966A priority Critical patent/RU2174505C1/en
Priority claimed from RU2000103966A external-priority patent/RU2174505C1/en
Application granted granted Critical
Publication of RU2174505C1 publication Critical patent/RU2174505C1/en
Publication of RU2000103966A publication Critical patent/RU2000103966A/en

Links

Claims (3)

1. Способ получения функционально замещенного метиленциклобутана путем взаимодействия аллена с производным этилена, содержащим группу: -СООН или -COOR, или -CN, при повышенной температуре, с последующим разделением продуктов реакции и ректификационным выделением целевого продукта, отличающийся тем, что процесс проводят в паровой фазе, причем в качестве источника аллена используют алленсодержащий газ с содержанием аллена от 10 до 80%, при температуре выше 350oС и давлении 0,1-1,0 мПа, до конверсии аллена не выше 60%, на выходе из реактора продукты реакции закаливают и разделяют ректификацией, целевой продукт отводят в качестве товарного, непрореагировавшие аллен и производное этилена возвращают в процесс.1. A method of producing a functionally substituted methylene cyclobutane by reacting allene with an ethylene derivative containing a group: —COOH or —COOR or —CN, at elevated temperature, followed by separation of the reaction products and distillation of the target product, characterized in that the process is carried out in steam phase, and as allene source used allensoderzhaschy allene gas containing from 10 to 80% at a temperature above 350 o C and pressure 0.1-1.0 mPa, to convert allene not higher than 60% at the reactor outlet products ReA tion is quenched and separated by distillation, the desired product is withdrawn as a trademark, and allene derivative unreacted ethylene is recycled into the process. 2. Способ по п.1, отличающийся тем, что процесс проводят предпочтительно до конверсии аллена 20-30%. 2. The method according to claim 1, characterized in that the process is preferably carried out before the conversion of allen 20-30%. 3. Способ по п.1 или 2, отличающийся тем, что процесс проводят предпочтительно при температуре 400-550oС и давлении 0,3-0,6 мПа.3. The method according to claim 1 or 2, characterized in that the process is carried out preferably at a temperature of 400-550 o C and a pressure of 0.3-0.6 MPa.
RU2000103966A 2000-02-18 2000-02-18 Method of preparing functionally substituted methylene cyclobutane RU2174505C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2000103966A RU2174505C1 (en) 2000-02-18 2000-02-18 Method of preparing functionally substituted methylene cyclobutane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2000103966A RU2174505C1 (en) 2000-02-18 2000-02-18 Method of preparing functionally substituted methylene cyclobutane

Publications (2)

Publication Number Publication Date
RU2174505C1 RU2174505C1 (en) 2001-10-10
RU2000103966A true RU2000103966A (en) 2001-11-10

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RU2000103966A RU2174505C1 (en) 2000-02-18 2000-02-18 Method of preparing functionally substituted methylene cyclobutane

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RU (1) RU2174505C1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2386556A1 (en) 2005-09-22 2011-11-16 Abbott Laboratories Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106748630A (en) * 2016-11-28 2017-05-31 孟祥寨 A kind of synthetic method of antalgesic intermediate Bromomethylcyclobutane
CN107805197A (en) * 2017-11-24 2018-03-16 常州沃腾化工科技有限公司 A kind of synthetic method of cyclobutyl formate
CN113493396A (en) * 2020-04-08 2021-10-12 南京药石科技股份有限公司 Process for preparing 3-methylenecyclobutyl derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2386556A1 (en) 2005-09-22 2011-11-16 Abbott Laboratories Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands

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