RU2000103216A - NEW COMPOSITION - Google Patents
NEW COMPOSITIONInfo
- Publication number
- RU2000103216A RU2000103216A RU2000103216/14A RU2000103216A RU2000103216A RU 2000103216 A RU2000103216 A RU 2000103216A RU 2000103216/14 A RU2000103216/14 A RU 2000103216/14A RU 2000103216 A RU2000103216 A RU 2000103216A RU 2000103216 A RU2000103216 A RU 2000103216A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical composition
- composition according
- paragraphs
- drying
- halogen
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 1
- 206010002383 Angina pectoris Diseases 0.000 claims 1
- -1 NR 6 R 7 Chemical group 0.000 claims 1
- 208000010110 Spontaneous Platelet Aggregation Diseases 0.000 claims 1
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 238000007496 glass forming Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Claims (10)
где R1 и R2 независимо обозначают водород или галоген, R3 и R4 независимо обозначают фенил или С1-6-алкил, необязательно замещенный одним или несколькими заместителями, выбранными из OR5, С1-6-алкилтио, NR6R7, фенила, COOR8 и галогена, R5, R6, R7 и R8 независимо обозначают водород или С1-6-алкил и Х обозначает кислотную часть молекулы, или его фармацевтически приемлемой солью.2. The pharmaceutical composition according to claim 1, wherein the nucleotide is a compound of formula (I)
where R 1 and R 2 independently represent hydrogen or halogen, R 3 and R 4 independently represent phenyl or C 1-6 alkyl optionally substituted with one or more substituents selected from OR 5 , C 1-6 alkylthio, NR 6 R 7 , phenyl, COOR 8 and halogen, R 5 , R 6 , R 7 and R 8 are independently hydrogen or C 1-6 alkyl and X is the acid part of the molecule, or a pharmaceutically acceptable salt thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9702680A SE9702680D0 (en) | 1997-07-11 | 1997-07-11 | New formulation |
| SE9702680-1 | 1997-07-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000103216A true RU2000103216A (en) | 2002-01-10 |
| RU2216330C2 RU2216330C2 (en) | 2003-11-20 |
Family
ID=20407718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000103216/14A RU2216330C2 (en) | 1997-07-11 | 1998-06-29 | Nucleotide analog-containing pharmaceutical composition and method for it preparing |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6130208A (en) |
| EP (1) | EP1000079B1 (en) |
| JP (1) | JP4950380B2 (en) |
| KR (1) | KR100786654B1 (en) |
| CN (2) | CN1864696A (en) |
| AR (1) | AR013157A1 (en) |
| AT (1) | ATE340801T1 (en) |
| AU (1) | AU8362598A (en) |
| BR (1) | BR9810703A (en) |
| CA (1) | CA2295628C (en) |
| CY (1) | CY1105805T1 (en) |
| CZ (1) | CZ298110B6 (en) |
| DE (1) | DE69836023T2 (en) |
| DK (1) | DK1000079T3 (en) |
| EE (1) | EE04119B1 (en) |
| ES (1) | ES2273425T3 (en) |
| HK (1) | HK1026429A1 (en) |
| HU (1) | HU226489B1 (en) |
| ID (1) | ID24716A (en) |
| IL (2) | IL133868A0 (en) |
| IS (1) | IS2439B (en) |
| MY (1) | MY116421A (en) |
| NO (1) | NO329918B1 (en) |
| NZ (1) | NZ502073A (en) |
| PL (1) | PL192768B1 (en) |
| PT (1) | PT1000079E (en) |
| RU (1) | RU2216330C2 (en) |
| SA (1) | SA98190328B1 (en) |
| SE (1) | SE9702680D0 (en) |
| SI (1) | SI1000079T1 (en) |
| SK (1) | SK285766B6 (en) |
| TR (1) | TR200000006T2 (en) |
| TW (1) | TW585764B (en) |
| UA (1) | UA65576C2 (en) |
| WO (1) | WO1999002542A1 (en) |
| ZA (1) | ZA985669B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006038647A1 (en) * | 2004-10-05 | 2006-04-13 | Asahi Kasei Pharma Corporation | Method for stabilizing coenzyme and composition therefor |
| WO2009140092A1 (en) | 2008-05-13 | 2009-11-19 | The Medicines Company | Maintenance of platelet inhibition during antiplatelet therapy |
| US20120141468A1 (en) | 2008-05-13 | 2012-06-07 | Lisa Ruderman Chen | Maintenance of platelet inhibition during antiplatelet therapy |
| US8759316B2 (en) | 2008-05-13 | 2014-06-24 | The Medicines Company | Maintenance of platelet inhibition during antiplatelet therapy |
| US20130303477A1 (en) | 2008-05-13 | 2013-11-14 | The Medicines Company | Maintenance of Platelet Inhibition During Antiplatelet Therapy |
| US9427448B2 (en) | 2009-11-11 | 2016-08-30 | The Medicines Company | Methods of treating, reducing the incidence of, and/or preventing ischemic events |
| US9925265B2 (en) | 2009-11-11 | 2018-03-27 | Chiesi Farmaceutici S.P.A. | Methods of treating or preventing stent thrombosis |
| US8729095B2 (en) | 2009-08-28 | 2014-05-20 | Daiichi Sankyo Company, Limited | 3-(biaryloxy)propionic acid derivatives for prevention and/or treatment of thromboembolic diseases |
| US10376532B2 (en) | 2009-11-11 | 2019-08-13 | Chiesi Farmaceutici, S.P.A. | Methods of treating, reducing the incidence of, and/or preventing ischemic events |
| MX2013006127A (en) * | 2010-12-10 | 2013-09-26 | Sigmapharm Lab Llc | Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs. |
| CN103582480B (en) | 2011-02-09 | 2016-03-16 | 医药公司 | The method for the treatment of pulmonary hypertension |
| DK2744424T3 (en) | 2011-08-17 | 2018-01-22 | Samuel Shiber | Adaptively rotating catheter to open clogged vessels in the body |
| ES2904256T3 (en) | 2013-03-09 | 2022-04-04 | Chiesi Farm Spa | Methods to treat, reduce the incidence of, and/or prevent ischemic events |
| CN103772461A (en) * | 2014-01-06 | 2014-05-07 | 南京正科制药有限公司 | Cangrelor crystal form I |
| BR112017014996A2 (en) | 2015-01-14 | 2018-03-20 | Chiesi Farm Spa | pharmaceutical formulations and sealed containers |
| WO2018234565A1 (en) | 2017-06-23 | 2018-12-27 | Chiesi Farmaceutici S.P.A. | Method of preventing of systemic-to-pulmonary-artery shunt thrombosis |
| CN112469710B (en) | 2018-06-19 | 2024-05-14 | 优时比制药有限公司 | Pyridyl and pyrazinyl- (aza) indole sulfonamides |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5637967B2 (en) * | 1973-05-17 | 1981-09-03 | ||
| JPS5874966A (en) * | 1981-10-28 | 1983-05-06 | Mikuni Jukogyo Kk | Shaft sealing device of high pressure reciprocating machine |
| JPS5874696A (en) * | 1981-10-30 | 1983-05-06 | 株式会社 ヤトロン | Stabilization of adenosine triphosphate |
| AU659645B2 (en) * | 1991-06-26 | 1995-05-25 | Inhale Therapeutic Systems | Storage of materials |
| KR0131678B1 (en) * | 1991-12-09 | 1998-04-17 | 유미꾸라 레이이찌 | Stabilized parathyroid hormone composition |
| DE69406649T2 (en) * | 1993-02-10 | 1998-03-05 | Astra Pharmaceuticals Ltd., Kings Langley, Hertfordshire | N-ALKYL-2 SUBSTITUTED ATP ANALOGS |
| RU2135176C1 (en) * | 1993-12-14 | 1999-08-27 | Эли Лилли Энд Компани | Water-dissolved inclusion complex of benzothiophene compounds with water-soluble cyclodextrin, method of synthesis and pharmaceutical composition |
| DE4405426A1 (en) * | 1994-02-21 | 1995-08-24 | Boehringer Mannheim Gmbh | Pharmaceutical preparation containing plasminogen activator (t-PA) or its derivatives |
| AU707734B2 (en) * | 1995-06-07 | 1999-07-15 | Regents Of The University Of California, The | Stabilization of polynucleotide complexes |
| FR2740686B1 (en) * | 1995-11-03 | 1998-01-16 | Sanofi Sa | STABLE LYOPHILIZED PHARMACEUTICAL FORMULATION |
| ID21635A (en) * | 1996-12-20 | 1999-07-08 | Astra Pharma Prod | PHARMACEUTICAL COMPOSITION FOR FROZEN DRYING |
-
1997
- 1997-07-11 SE SE9702680A patent/SE9702680D0/en unknown
-
1998
- 1998-06-19 TW TW087109890A patent/TW585764B/en not_active IP Right Cessation
- 1998-06-29 SI SI9830865T patent/SI1000079T1/en unknown
- 1998-06-29 CA CA002295628A patent/CA2295628C/en not_active Expired - Lifetime
- 1998-06-29 ID IDW20000028A patent/ID24716A/en unknown
- 1998-06-29 PL PL337970A patent/PL192768B1/en unknown
- 1998-06-29 DE DE69836023T patent/DE69836023T2/en not_active Expired - Lifetime
- 1998-06-29 ES ES98934017T patent/ES2273425T3/en not_active Expired - Lifetime
- 1998-06-29 UA UA2000010491A patent/UA65576C2/en unknown
- 1998-06-29 IL IL13386898A patent/IL133868A0/en unknown
- 1998-06-29 ZA ZA985669A patent/ZA985669B/en unknown
- 1998-06-29 CN CNA2006100092846A patent/CN1864696A/en active Pending
- 1998-06-29 EE EEP200000022A patent/EE04119B1/en unknown
- 1998-06-29 TR TR2000/00006T patent/TR200000006T2/en unknown
- 1998-06-29 RU RU2000103216/14A patent/RU2216330C2/en active
- 1998-06-29 CN CN98807089A patent/CN1263533A/en active Pending
- 1998-06-29 US US09/125,165 patent/US6130208A/en not_active Expired - Lifetime
- 1998-06-29 AT AT98934017T patent/ATE340801T1/en active
- 1998-06-29 CZ CZ20000083A patent/CZ298110B6/en not_active IP Right Cessation
- 1998-06-29 BR BR9810703-8A patent/BR9810703A/en not_active Application Discontinuation
- 1998-06-29 DK DK98934017T patent/DK1000079T3/en active
- 1998-06-29 NZ NZ502073A patent/NZ502073A/en not_active IP Right Cessation
- 1998-06-29 SK SK1836-99A patent/SK285766B6/en not_active IP Right Cessation
- 1998-06-29 AU AU83625/98A patent/AU8362598A/en not_active Abandoned
- 1998-06-29 WO PCT/SE1998/001287 patent/WO1999002542A1/en active IP Right Grant
- 1998-06-29 HU HU0002622A patent/HU226489B1/en unknown
- 1998-06-29 KR KR1020007000205A patent/KR100786654B1/en not_active IP Right Cessation
- 1998-06-29 PT PT98934017T patent/PT1000079E/en unknown
- 1998-06-29 EP EP98934017A patent/EP1000079B1/en not_active Expired - Lifetime
- 1998-06-29 JP JP2000502063A patent/JP4950380B2/en not_active Expired - Lifetime
- 1998-06-30 AR ARP980103182A patent/AR013157A1/en not_active Application Discontinuation
- 1998-07-10 MY MYPI98003170A patent/MY116421A/en unknown
- 1998-07-21 SA SA98190328A patent/SA98190328B1/en unknown
-
1999
- 1999-12-30 IS IS5331A patent/IS2439B/en unknown
-
2000
- 2000-01-03 IL IL133868A patent/IL133868A/en not_active IP Right Cessation
- 2000-01-10 NO NO20000123A patent/NO329918B1/en not_active IP Right Cessation
- 2000-09-05 HK HK00105603A patent/HK1026429A1/en not_active IP Right Cessation
-
2006
- 2006-11-27 CY CY20061101705T patent/CY1105805T1/en unknown
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