RU1826911C - Method of prophylaxis and treating atherosclerosis in experiment - Google Patents

Method of prophylaxis and treating atherosclerosis in experiment

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Publication number
RU1826911C
RU1826911C SU904841348A SU4841348A RU1826911C RU 1826911 C RU1826911 C RU 1826911C SU 904841348 A SU904841348 A SU 904841348A SU 4841348 A SU4841348 A SU 4841348A RU 1826911 C RU1826911 C RU 1826911C
Authority
RU
Russia
Prior art keywords
experiment
prophylaxis
treating atherosclerosis
cholesterol oxidase
cholesterol
Prior art date
Application number
SU904841348A
Other languages
Russian (ru)
Inventor
Анатолий Николаевич Климов
Василий Ефимович Рыженков
Кира Александровна Кожевникова
Наталья Николаевна Клюева
Владимир Федорович Трюфанов
Елена Владимировна Белова
Георгий Авксентьевич Михайлец
Григорий Ефимович Гринберг
Людмила Яковлевна Петрова
Original Assignee
Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср filed Critical Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср
Priority to SU904841348A priority Critical patent/RU1826911C/en
Application granted granted Critical
Publication of RU1826911C publication Critical patent/RU1826911C/en

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Abstract

Изобретение относитс  к экспериментальной медицине. Цель изобретени  - повышение эффективности терапии. Дл  этого в организм орально ввод т гиполипидеми- ческое средство - холестериноксидазу в микрогранулах.The invention relates to experimental medicine. The purpose of the invention is to increase the effectiveness of therapy. For this, a lipid-lowering agent, cholesterol oxidase in microgranules, is orally administered to the body.

Description

Изобретение относитс  к медицине, а именно к лекарственным средствам, оказывающим гиполипидемическое и антиатеро- склеротическое действие.The invention relates to medicine, namely to medicines having a lipid-lowering and anti-atherosclerotic effect.

Целью изобретени   вл етс  использование дл  профилактики и лечени  атеросклероза фермента микробного происхождени  - холестериноксидазы путем перорального его применени .The aim of the invention is the use for the prevention and treatment of atherosclerosis of an enzyme of microbial origin - cholesterol oxidase by its oral administration.

Дл  достижени  гиполипидемического эффекта препарат примен ют в микрогранулах . Отличием этого способа  вл етс  пероральное применение холестериноксидазы в низких дозах. Препарат хорошо переноситс , побочных эффектов не наблюдаетс , изменений в органах экспериментальных животных нет.In order to achieve a hypolipidemic effect, the preparation is used in microgranules. A difference of this method is the low dose oral administration of cholesterol oxidase. The drug is well tolerated, there are no side effects, and there are no changes in the organs of experimental animals.

Изобретете иллюстрируетс  следующим примером. Кролики, получающие холестерин в течение 12 дней, снижали массу тела на 220 г. Кролики, получающие вместе с холестериновой диетой перорально холе- стериноксидазу в дозе 1 - 50 ед. /кг, снижали, массу тела на 50 г. Уровень ХС-сыворотки крови у получающих холестериноксидазу на 30% ниже в сравнении с группой гиперхоле- стеринемических животных.The invention is illustrated by the following example. Rabbits receiving cholesterol for 12 days reduced their body weight by 220 g. Rabbits receiving an oral cholesterol oxidase dose of 1 to 50 units together with a cholesterol diet. / kg, reduced body weight by 50 g. The level of cholesterol-oxidizing blood serum levels is 30% lower in comparison with the group of hypercholesterolemic animals.

Claims (1)

Формула изобретени  Способ профилактики и лечени  атеросклероза в эксперименте путем орального введени  гиполипидемического средства, отличающийс  тем, что, с целью повышени  эффективности терапии, ввод т холестерииоксидазу в микрогранулахSUMMARY OF THE INVENTION A method for the prevention and treatment of atherosclerosis in an experiment by oral administration of a lipid-lowering agent, characterized in that, in order to increase the effectiveness of therapy, cholesterol oxidase is introduced in microgranules 0000 го о оgo about ыs
SU904841348A 1990-07-10 1990-07-10 Method of prophylaxis and treating atherosclerosis in experiment RU1826911C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU904841348A RU1826911C (en) 1990-07-10 1990-07-10 Method of prophylaxis and treating atherosclerosis in experiment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU904841348A RU1826911C (en) 1990-07-10 1990-07-10 Method of prophylaxis and treating atherosclerosis in experiment

Publications (1)

Publication Number Publication Date
RU1826911C true RU1826911C (en) 1993-07-07

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Family Applications (1)

Application Number Title Priority Date Filing Date
SU904841348A RU1826911C (en) 1990-07-10 1990-07-10 Method of prophylaxis and treating atherosclerosis in experiment

Country Status (1)

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RU (1) RU1826911C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010014541A3 (en) * 2008-07-28 2010-11-18 Alnara Pharmaceuticals, Inc. Compositions and methods for treatment of hypercholesterolemia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Машковский М.Д. Лекарственные средства. Пособие по фармаколотерапии дл врачей. М,: Медицина. 1987, изд.Х, т.2, с.88- 91. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010014541A3 (en) * 2008-07-28 2010-11-18 Alnara Pharmaceuticals, Inc. Compositions and methods for treatment of hypercholesterolemia

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