RU1792329C - Method for allergic diseases treatment - Google Patents

Abstract

A method for treating allergic diseases. The invention relates to medicine, in particular to allergology. The goal is to increase the effectiveness of treatment. For this, a histoglobulin preparation containing 0.6 ml of gamma globulin and 0.0002 mg of histamine in 1 ml is administered subcutaneously every other day from an initial dose of 0.2 ml to 0.8 ml, increasing the dose by 0.2 ml, then two days later on the third to 1.8 ml, after which four days later on the fifth, 2.0 ml are administered - ten injections. The method was tested in tens of thousands of patients in medical institutions of the Krasnodar Territory. Thanks to the use of the method, it was possible to increase the frequency of remission or clinical recovery by a factor of 2–3 with food allergies, neurodermatitis, urticaria, Quincke's edema, allergic rhinosinusitis.

Description

The invention relates to medicine, in particular to allergology.

The goal is to increase the effectiveness of treatment.

The method is carried out as follows. To prepare the histaglobulin preparation, b ml of an ampoule 10% solution of placental gammaglobulin and 2 ml of a 0.01% histamine dihydrochloride solution are successively added to a vial of 992 ml of sterile physiological saline. After mixing the preparation under sterile conditions, the vial is dispensed with an AN-2 dispenser. Sterility is checked on sugar broth for 8 days. Shelf life of the drug is 1 year at a temperature of +2 - + 6 ° C. The patient is injected with the prepared histaglobulin preparation subcutaneously every other day from an initial dose of 0.2 ml to 0.8 ml, increasing the dose by 0.2 ml, then after 2 days on the third to 1.8 ml, after which it is administered four days later fifth, 2.0 ml of ten injections.

Examples of specific implementation of the method.

Example 1. Patient K., 42 years old, suffers from urticaria for 8 years. On admission, urtikarny elements ranging in size from a pea to a pebble coin were marked on various skin areas, especially in the abdomen, back, and forearms. Concerned by the constant itching, worse at night. After 3 days of treatment with an allergy-free diet and antihistamines, the patient underwent a course of treatment with histaglobulin according to the scheme. Immediately at the end of the course, the skin manifestations decreased, and after 2 weeks the skin cleared, the itching stopped. After 2 months, the course of treatment with histagluboline was repeated. In the next 3 years, during the dynamic observation of the disease recurrence was not observed, did not need treatment, removed from the dispensary.

PRI me R 2. Patient G., 52 years old, suffers from Quincke's edema for 12 years. Food allergies to eggs, chocolate, coffee, nuts.

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citrus fruits, bird meat, fish, years. Upon receipt of a complaint. Periodically difficulty swallowing, hoarseness of the voice, swelling of the lips, skin in the palms and soles of the feet, itching of the skin. After 3 days of an allergy-free diet and the use of antihistamines, a course of treatment with histaglobulin was carried out according to the scheme. Significant improvement achieved. At intervals of 2 months, a second and third course of treatment was performed. Clinical manifestations have completely disappeared. During dynamic observation for 5 years, relapse was not observed. Almost healthy.

The method has been tested in tens of thousands of patients in various medical institutions of the Krasnodar Territory for 27 years. Compared to traditional methods of administering standard histzglobulin, the inventive method provided a twofold increase in the frequency of remissions or clinical recovery of malaria in allergic diseases such as urticaria and edema. Duration of remission over 5 years after 3 courses of observation therapy, respectively, in 36% and 67.5% of patients with urticaria, in 27% and 71.5% of patients with edema

Quincke, Excellent results were also obtained when using the method in the treatment of allergic rhinusinusitis. neurodermatitis, food allergies. The positive effect during treatment by the infusion method increased from 48% to 89% for allergic rhinosinusitis, from 25% to 56% for neurodermatitis, and from 17.4% to 39.4% for food allergy. The method has also been successfully used in the treatment of allergic diseases in children, while exacerbations during therapy with histaglobulin of the underlying disease decreased from 22% to 0.7%.

Claims (1)

SUMMARY OF THE INVENTION A method for treating allergic diseases, comprising administering a preparation containing gamma globulin and histamine, characterized in that, in order to increase the effectiveness of the treatment, a preparation containing 1 ml of a solution of 0.6 mg of gammaglobulin and 0.0002 ml of histamine is administered , subcutaneously every other day from an initial dose of 0.2 ml, increasing the dose by 0.2 ml to 0.8 ml, then after two days - also to 1.8 ml, after which four days later on the fifth - 2.0 ml ten injections.