RU147197U1 - DEVICE FOR THAWING AND HEATING OF BLOOD COMPONENTS AND INFUSION SOLUTIONS - Google Patents

Abstract

A device for thawing and heating blood components and infusion solutions frozen in plastic containers, containing a housing that can be closed on top with a lid located inside the bathtub with a liquid coolant, heating elements for heating the specified coolant and maintaining a given temperature, a temperature sensor connected to a control circuit for controlling parameters increasing the temperature of the liquid coolant during the thawing and heating of plastic containers in a removable bath and maintaining the temperature of this coolant at a level selected on the control panel, a means of mixing the coolant fluid located in the housing, as well as means for placing the plastic containers in the bath in a suspended position and a timer associated with a control circuit for issuing a signal to turn off the heating mode of the coolant, characterized in that it is equipped with a chamber in which the heating elements are placed and into which the completed removable bath is inserted, means for mixing the liquid heat the carrier is made in the form of at least one pump located under the bath in the chamber to ensure constant circulation of the coolant in the bath, the means for placing the plastic containers in the bath in a suspended position is made in the form of a removable silicone holder having a frame or platform for supporting on the perimeter bathtubs and recesses, which are recessed in the coolant nests for placement in each one plastic container to prevent contact of the specified container with this coolant.

Description

The utility model relates to the field of medicine and biology, and in particular to devices for rapid thawing and heating of freshly frozen plasma and frozen cryoprecipitate after storage in a frozen state immediately before transfusion to a patient, as well as for heating solutions in containers or vials. The plasma thawer is designed for gentle, safe, uniform and quick thawing and heating of frozen cryoprecipitate and freshly frozen plasma. The use of a thawer is required to thaw the composition immediately before transfusion. Scope of the plasma thawer: blood services that carry out blood transfusion therapy, and hospitals (resuscitation, operating unit, intensive care unit).

One of the most common methods of preserving human blood is its fractionation, followed by freezing of the fractions; before use, the fractions are thawed. Severe restrictions are imposed on the modes of transition from one phase state to another. When freezing and thawing human blood plasma, the temporal function of changing its temperature is set linear, its steepness during thawing should be at least 5 ° C / min. At the moment the plasma defroster reaches a temperature of 37 ° C, the blood plasma (cryoprecipitate) must be stabilized, the permissible deviation of the blood plasma temperature from 37 ° C must not exceed ± 0.5 ° C during the whole time of thermal stabilization. Heating blood plasma above 37.5 ° C leads to an increase in the likelihood of protein clotting, which means it can threaten the patient’s health if the temperature of the transfused plasma is lower than 36.5 ° C, the patient is uncomfortable due to a feeling of cold (http: // giperion- msk.ru/content/view/61/31/).

There are plasma defrosters of various capacities and functionality, but all of them are united by a similar design: the stainless steel bath serves as a heating tank, and the water that is poured into the bath and heated to the desired temperature acts as a heat carrier. Plasma intended for heating is placed in a defroster in special containers or bottles. The device eliminates the mechanical impact on the defrosted object, protects against overheating and provides gentle thawing while maintaining all its important characteristics. As a rule, the transparent defrost lid allows personnel to control the heating process. The inside of the appliance is easy to clean and disinfect.

So, the known defrosting blood plasma "MT-210 PLASMA THAWER OPERATOR'S MANUAL Rev. A ”manufactured by TermoGenesis Corp. (THERMO), Canada, 1998. The specified plasma thawer includes a thawing chamber, a top cover with flexible pockets, a mechanical arm, a heating element, a temperature controller, a control panel, and a water supply fitting. Plasma thawing is carried out from a temperature of -25 to + 37 ° C at a water temperature in the thawing chamber from 35 to 37 ° C, and the maximum number of plastic bags with plasma is 10 pcs. A disadvantage of the known plasma thawer is that the water temperature is controlled in a very narrow range (35 ÷ 37 ° C), which does not allow the use of this thawer to isolate factor VIII from frozen blood plasma, followed by centrifugation of blood plasma at a temperature of no more than + 8 ° C .

A device for defrosting blood plasma is also known, including a stainless steel bath with distilled water, a heating and cooling device at the bottom of the bath, a temperature sensor, a control circuit, an electric stirrer included in the actuator circuit of the control circuit, a liquid level sensor in the bath connected at the input of the control circuit, the bath is equipped with channels for fluid flow from the end of the bath to the compartment where the mixer is located, the mixer is separated from the rest of the bath by a partition with holes, the bath equipped with a grating for staggering plasma bags, while the cooling evaporator and heating device are located directly in the bath, the liquid level sensor is located in the bath compartment, separated from the rest of the bath by vertical partitions and communicating with the bath through the connecting hole in the lower part of the specified compartment and a timer is introduced in the control circuit (RU 2280460, A6K 35/14, A61M 5/44, published on July 27, 2006).

The disadvantage of this device is that the process of mixing water takes place in a separate chamber, separated by a partition from the chamber where the bags of plasma are located. That is, mixing in this separate chamber is carried out to ensure uniform stabilization of the water temperature. This leads to the fact that in the chamber where the bags with plasma are located, the water is in a calm state and does not wash these bags. This affects the defrosting time of the product.

The use of a lattice design to place plasma bags directly in heated water leads to the fact that the bags can be washed both by heated layers (streams) of water and unheated streams. The uneven effect of water on the surface of the bags excites the uneven thawing of the product in the bag.

An innovative approach in the field of blood transfusion is possible only with the latest equipment. In particular, the biological value of the substance and the result of transfusion depend on the work of a modern defroster. New developments of universal, compact and mobile defrosters are needed, including the possibility of wave-like movement for delicate mixing of deep-frozen substances. Automated control, an intuitive menu, a display that displays all the necessary information about the current cycle, ease of use in routine practice are all important characteristics of a good plasma defroster. In this case, the plasma thawer should exclude mechanical effects on the defrosted object. The device should provide the ability to quickly, conveniently and safely thaw cryopreserved plasma and other blood products without disturbing the biological composition, and also maintain the activity of procoagulants (I, II, V, VIII: C factors) and antithrombin III (ATIII), which is necessary in hematology, resuscitation and emergency surgery.

This utility model is aimed at achieving a technical result, which consists in increasing operational characteristics by reducing the time to thaw a frozen product and the formation of an optimized heat transfer from the coolant to the product through a heat-distributing intermediary.

The specified technical result is achieved by the fact that a device for thawing and heating blood components and infusion solutions frozen in plastic containers, containing a housing closed on top with a lid placed inside a bath with a liquid coolant, heating elements for heating the specified coolant and maintaining a given temperature, a temperature sensor, associated with a control circuit for controlling the parameters of increasing the temperature of the liquid coolant during thawing and heating plastic containers in a removable bath and maintain the temperature of this coolant at a level selected on the control panel, liquid coolant mixing means located in the housing, as well as means for placing plastic containers in the bath in a suspended position and a timer associated with a control circuit for issuing a signal to switching off the heating mode of the heat-transfer fluid, equipped with a chamber in which the heating elements are placed and into which the completed removable bath is inserted, sewing the liquid coolant is made in the form of at least one pump located in the chamber under the bath to ensure constant circulation of the coolant in the bath, the means for placing plastic containers in the bath in a suspended position is made in the form of a removable silicone holder having a frame or platform for supporting on the perimeter of the bath and recesses, which are recessed in the coolant nests for placement in each one plastic container to prevent contact of the specified package or container or bag with this coolant.

These features are significant and are interconnected with the formation of a stable set of essential features sufficient to obtain the desired technical result.

The present utility model is illustrated by a specific example of execution, which, however, is not the only possible one, but clearly demonstrates the possibility of achieving the required technical result.

In FIG. 1 is an exploded perspective view of a device for rapidly thawing and heating blood components and infusion solutions;

FIG. 2 - section of the device in the bath;

FIG. 3 is a top view of the lid.

According to this utility model, we consider the design of a device for rapid thawing and heating of blood components and infusion solutions (hereinafter referred to as thawing), designed for uniform, safe and quick thawing and heating of blood plasma, blood substitutes, cryoprecipitate and infusion solutions frozen in plastic containers - in bags or containers or bags or bottles. Thaw can be used in resuscitation and surgery departments, at blood transfusion stations of hospitals, clinics, hospitals, obstetrics and childhood departments, and stem cell treatment centers.

A device for thawing and heating blood components and infusion solutions (Fig. 1), frozen in plastic containers or bottles, contains a housing 2 closed on top by a lid 1 with a heat transfer fluid 3 inside the bath. The case is made of a metal sheet and consists of a front 4 panel, a rear 5 panel and side walls 6. A cover 1, hinged on hinges 7, is provided to ensure a safe mode of operation for medical personnel and protect thawed, heated objects from environmental influences.

The thawer is made with metallic and non-metallic inorganic coatings in accordance with GOST 9.301 for operating conditions I in accordance with GOST 9.303. Paint and varnish coatings of external surfaces comply with GOST 9.401 for operating conditions of UHL 4 GOST 9.104 and have coatings of at least class III according to GOST 9.032. The outer surfaces of the thawer are resistant to disinfection according to MU 287-113-98: 3% hydrogen peroxide solution with the addition of a 0.5% detergent solution according to GOST 25644.

A stainless steel chamber 3 is mounted inside the frame for heating the heat-transfer fluid. The camera is mounted on brackets 8, providing mounting rigidity and safe operation of the device. In the chamber, heating elements 9 are installed, providing heating of the coolant and maintaining a predetermined temperature. Bathroom 10 in the form of a removable container is installed in the chamber and communicates with the means of mixing the liquid coolant. The pump / s are located under the bath in the chamber to ensure constant circulation of the coolant in the bath.

Means of mixing the coolant are located in the chamber outside the bath. By this means is meant a device for pumping a coolant located in the lower part of the chamber and performing the function of mixing thawed and warmed objects - packages or containers or bags or bottles. The fluid coolant mixing means is made in the form of at least one pump 11 located in the chamber to ensure constant circulation of the coolant in the bath.

The camera is equipped with a temperature sensor 12, which controls the temperature of the coolant during defrosting and heating of objects in a removable metal bath 3. The temperature sensor is connected to a control circuit for controlling the temperature increase parameters of the coolant in the process of thawing and heating plastic containers in a removable bath and maintain the temperature of this coolant at the level 13 selected on the control panel, which is set by the user in accordance with the established standards. The most admissible temperature in the mode of defrosting is 37.8 ° C, no more. The control circuit provides four temperature control modes:

Defrosting time in the "PLASMA" mode - 18 minutes, no more.

Defrosting time in the “CRIO” mode - 6 minutes, no more.

The warming time in the BLOOD mode is 15 minutes.

Defrosting time in the STEM CELL mode - 5 min.

The device is controlled by electronic devices of the control circuit, which include a control unit 14, a temperature sensor 12, as well as a network switch 15, when pressed, the process of automatic heating of the coolant in the bath begins. A film-membrane control panel 13 is glued onto the upper panel 16 of the housing. The control panel 13 is equipped with a large LED display 17 (indicator), which simplifies the visualization of parameters during operation of the device, and control buttons. The defrosting control circuit may have the ability to connect to a computer for monitoring, control, logging and reporting on the main operating modes.

The heating element is switched on when the defroster is connected to the network through the control circuit. Confirmation of the selection of the operating mode through the "START" button, after which the pumps automatically turn on after selecting the operating mode of the defroster.

On the indicator of the control panel 13 appears the time and type of the operating mode of the defrost:

- 18 min when the key is turned on - “PLASMA”

- 15 minutes when you turn on the key - "BLOOD"

- 6 minutes when you turn on the key - "CRIO"

- 5 minutes when the key is turned on - “STEM CELLS”

- 3 min. “THERMOSTABILIZATION” mode after each operating mode.

After the time of the operating mode, the control circuit provides an automatic transition to thermal stabilization mode. The display of the operating mode time from the set value to the end of the operating modes takes place with a resolution of 1 second. At the end of the operating mode, a sound signal appears. When the maximum permissible temperature is exceeded, the heating element turns off, a sound signal is given and an inscription appears on the “OVERHEAT” indicator. If the water level in the chamber is insufficient, the heating element and pumps turn off, a sound signal sounds and the inscription “LOW WATER LEVEL” appears on the monitor.

The control circuit includes a timer used to issue a signal to turn off the heating mode of the liquid coolant when the set time is reached.

The device comprises means for placing the plastic containers in the bath in a suspended position. This means for placing the plastic containers in the bath in a suspended position is made in the form of a removable silicone holder 18 having a perimeter frame or platform for supporting the perimeter of the bathtub or chamber and recesses, which are recessed in the coolant by sockets 19 for placement in each one plastic container for exclusion contact of the specified package or container or bag with this coolant.

The principle of "dry" thawing and heating of the components is carried out through the use of a removable silicone holder 18, the design of which provides the most efficient heat transfer process between the coolant and the heated object. Depending on the geometric shape and size of the heated object, a silicone holder is provided, mounted on an appropriate platform or frame. A faucet 20 is installed on the right side wall of the casing to drain the coolant from the chamber during preventive measures. Since the plastic containers can be of different shapes and different capacities, a set of removable silicone holders 18 is used, in each of which the nests have the shape of a product placed in them. In the silicone holder, the number of sockets - 4 pcs., No less.

The thawer provides simultaneous loading of plastic containers from 1 to 8 pcs. With a volume of up to 500 ml (with a capacity of up to 300 ml).

In addition, the device may be able to mix thawed and warmed objects due to the wave-like movement of the bathtub or the frame or platform of the silicone holder.

Placing the bath in the chamber allows you to install under it heating elements that heat the bath with a liquid coolant and pump units. Since the bathtub is removable, access to these units for technological maintenance is facilitated. Placing containers not directly in the coolant, but in a silicone holder placed in the coolant, provides indirect heating of the product due to the fact that silicone acts as an intermediary that evenly distributes heat on the surface of the holder. Local areas of overheating or underheating are excluded. In this regard, it becomes possible to accelerate thawing due to the fact that there is no need to bring the heat carrier to a state of evenly distributed temperature. This distribution is transferred to the silicone holder. In this regard, it becomes possible to quickly heat up the coolant. In addition, pumping in closed-loop mode of the coolant leads to its agitation and a rapid uniform distribution of heat. Pereboltivanie solution is carried out in the mode of pumping out the coolant and its jet feed into the bathtub with one or more pumps. When using several pumps, the mixing effect is most pronounced and allows you to drastically reduce the time to withdraw the coolant to a given level of heating. The requirements for the characteristics of the coolant and the quality of its heating can be reduced by a compensator in the form of a silicone holder that evens out the heat distribution on the walls of the nests.

this utility model is industrially applicable, as it can be manufactured using those technologies that are already used in the manufacture of medical equipment.

Claims (1)

A device for thawing and heating blood components and infusion solutions frozen in plastic containers, containing a housing that can be closed on top with a lid located inside the bathtub with a liquid coolant, heating elements for heating the specified coolant and maintaining a given temperature, a temperature sensor connected to a control circuit for controlling parameters increasing the temperature of the liquid coolant during the thawing and heating of plastic containers in a removable bath and maintaining the temperature of this coolant at a level selected on the control panel, a means of mixing the coolant fluid located in the housing, as well as means for placing the plastic containers in the bath in a suspended position and a timer associated with a control circuit for issuing a signal to turn off the heating mode of the coolant, characterized in that it is equipped with a chamber in which the heating elements are placed and into which the completed removable bath is inserted, means for mixing the liquid heat the carrier is made in the form of at least one pump located under the bath in the chamber to ensure constant circulation of the coolant in the bath, the means for placing the plastic containers in the bath in a suspended position is made in the form of a removable silicone holder having a frame or platform for supporting on the perimeter bathtubs and recesses, which are recessed in the coolant nests for placement in each one plastic container to prevent contact of the specified container with this coolant.

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