RS64692B1 - Vodena formulacija koja sadrži 1-(4-{[4-(dimetilamino)piperidin-1-il]karbonil}fenil)-3-[4-(4,6-dimorfolin-4-il-1,3,5-triazin-2-il)fenil]ureu - Google Patents

Vodena formulacija koja sadrži 1-(4-{[4-(dimetilamino)piperidin-1-il]karbonil}fenil)-3-[4-(4,6-dimorfolin-4-il-1,3,5-triazin-2-il)fenil]ureu

Info

Publication number
RS64692B1
RS64692B1 RS20230948A RSP20230948A RS64692B1 RS 64692 B1 RS64692 B1 RS 64692B1 RS 20230948 A RS20230948 A RS 20230948A RS P20230948 A RSP20230948 A RS P20230948A RS 64692 B1 RS64692 B1 RS 64692B1
Authority
RS
Serbia
Prior art keywords
phenyl
dimorpholin
triazin
piperidin
dimethylamino
Prior art date
Application number
RS20230948A
Other languages
English (en)
Inventor
James Joseph Hussey
Andrew Gilbert Bright
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of RS64692B1 publication Critical patent/RS64692B1/sr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
RS20230948A 2018-06-07 2019-06-04 Vodena formulacija koja sadrži 1-(4-{[4-(dimetilamino)piperidin-1-il]karbonil}fenil)-3-[4-(4,6-dimorfolin-4-il-1,3,5-triazin-2-il)fenil]ureu RS64692B1 (sr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862681722P 2018-06-07 2018-06-07
US201862754651P 2018-11-02 2018-11-02
US201962796133P 2019-01-24 2019-01-24
US201962841882P 2019-05-02 2019-05-02
EP19742898.0A EP3810089B1 (en) 2018-06-07 2019-06-04 Aqueous formulation comprising 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
PCT/IB2019/054643 WO2019234632A1 (en) 2018-06-07 2019-06-04 Aqueous formulation comprising 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea

Publications (1)

Publication Number Publication Date
RS64692B1 true RS64692B1 (sr) 2023-11-30

Family

ID=67402968

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20230948A RS64692B1 (sr) 2018-06-07 2019-06-04 Vodena formulacija koja sadrži 1-(4-{[4-(dimetilamino)piperidin-1-il]karbonil}fenil)-3-[4-(4,6-dimorfolin-4-il-1,3,5-triazin-2-il)fenil]ureu

Country Status (23)

Country Link
US (1) US20210212944A1 (sr)
EP (2) EP4249069A3 (sr)
JP (2) JP7423200B2 (sr)
KR (2) KR20230142810A (sr)
CN (2) CN116270452A (sr)
AU (2) AU2019283550B2 (sr)
BR (1) BR112020023891A2 (sr)
CA (1) CA3102527A1 (sr)
DK (1) DK3810089T3 (sr)
ES (1) ES2956225T3 (sr)
FI (1) FI3810089T3 (sr)
HR (1) HRP20231337T1 (sr)
HU (1) HUE063493T2 (sr)
IL (1) IL279270A (sr)
LT (1) LT3810089T (sr)
MX (1) MX2020013238A (sr)
PL (1) PL3810089T3 (sr)
PT (1) PT3810089T (sr)
RS (1) RS64692B1 (sr)
SG (1) SG11202011256RA (sr)
SI (1) SI3810089T1 (sr)
TW (1) TWI696469B (sr)
WO (1) WO2019234632A1 (sr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3672571B1 (en) 2017-08-25 2021-10-06 Pfizer Inc. Pharmaceutical aqueous formulation comprising 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
AU2022320615A1 (en) 2021-07-26 2024-03-14 Celcuity Inc. 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea (gedatolisib) and its combinations for use in the treatment of cancer

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5298410A (en) * 1993-02-25 1994-03-29 Sterling Winthrop Inc. Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life
CA2454913A1 (en) * 2001-08-20 2003-02-27 Boehringer Ingelheim Pharmaceuticals, Inc. Parenteral formulations of 1-(5-tert-butyl-2-p-tolyl-2h-pryrazol-3-yl)-3-¬4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl|-urea and a cyclodextrin
CN101309707A (zh) * 2005-11-15 2008-11-19 巴克斯特国际公司 含有脂氧化酶抑制剂和环糊精的组合物
WO2009143317A1 (en) * 2008-05-23 2009-11-26 Wyeth Triazine compounds as p13 kinase and mtor inhibitors
WO2010096619A1 (en) 2009-02-23 2010-08-26 Wyeth Llc Process, purification and crystallization of 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
AR081364A1 (es) * 2010-05-05 2012-08-29 Glaxo Wellcome Mfg Pte Ltd Composiciones farmaceuticas de pazopanib y metodos para su elaboracion
WO2014121235A2 (en) * 2013-02-01 2014-08-07 Zoneone Pharma, Inc. Transformation of drug cyclodextrin complex compositions into compositions of mixtures of lipid vesicle encapsulated drug and cyclodextrin drug complexes
BR112016021130A2 (pt) * 2014-03-14 2017-08-15 Pfizer Nanopartículas terapêuticas, composição farmacêutica compreendendo as referidas nanopartículas, processo para a preparação e uso das mesmas
DK3233054T3 (da) * 2014-12-17 2021-08-02 Pfizer Formuleringer af en PI3K/MTOR-hæmmer til intravenøs administration
KR101829705B1 (ko) * 2016-09-21 2018-02-19 씨제이헬스케어 주식회사 안정성이 향상된 주사용 조성물
EP3672571B1 (en) * 2017-08-25 2021-10-06 Pfizer Inc. Pharmaceutical aqueous formulation comprising 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea

Also Published As

Publication number Publication date
AU2022211854A1 (en) 2022-08-25
KR20230142810A (ko) 2023-10-11
US20210212944A1 (en) 2021-07-15
CN112218618A (zh) 2021-01-12
HUE063493T2 (hu) 2024-01-28
FI3810089T3 (fi) 2023-09-22
ES2956225T3 (es) 2023-12-15
AU2019283550B2 (en) 2022-06-16
EP3810089A1 (en) 2021-04-28
TWI696469B (zh) 2020-06-21
EP3810089B1 (en) 2023-08-02
HRP20231337T1 (hr) 2024-02-16
SI3810089T1 (sl) 2023-11-30
SG11202011256RA (en) 2020-12-30
LT3810089T (lt) 2023-11-10
JP7423200B2 (ja) 2024-01-29
DK3810089T3 (en) 2023-09-25
WO2019234632A1 (en) 2019-12-12
JP2023138872A (ja) 2023-10-02
AU2019283550A1 (en) 2020-12-10
TW202000234A (zh) 2020-01-01
CN116270452A (zh) 2023-06-23
AU2022211854B2 (en) 2024-01-04
EP4249069A2 (en) 2023-09-27
BR112020023891A2 (pt) 2021-02-09
IL279270A (en) 2021-01-31
MX2020013238A (es) 2021-02-22
JP2019218338A (ja) 2019-12-26
CA3102527A1 (en) 2019-12-12
PT3810089T (pt) 2023-08-23
KR102583563B1 (ko) 2023-10-05
EP4249069A3 (en) 2023-11-29
KR20210018341A (ko) 2021-02-17
PL3810089T3 (pl) 2024-04-08

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