RS57137B1 - Analog mini-gastrina, naročito za upotrebu u dijagnozi i/ili tretmanu tumora pozitivnog na cck2 receptor - Google Patents

Analog mini-gastrina, naročito za upotrebu u dijagnozi i/ili tretmanu tumora pozitivnog na cck2 receptor

Info

Publication number
RS57137B1
RS57137B1 RS20180451A RSP20180451A RS57137B1 RS 57137 B1 RS57137 B1 RS 57137B1 RS 20180451 A RS20180451 A RS 20180451A RS P20180451 A RSP20180451 A RS P20180451A RS 57137 B1 RS57137 B1 RS 57137B1
Authority
RS
Serbia
Prior art keywords
mini
treatment
receptor positive
positive tumour
cck2 receptor
Prior art date
Application number
RS20180451A
Other languages
English (en)
Inventor
Martin Behe
Roger Schibli
Original Assignee
Scherrer Inst Paul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherrer Inst Paul filed Critical Scherrer Inst Paul
Publication of RS57137B1 publication Critical patent/RS57137B1/sr

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2207Gastrins; Cholecystokinins [CCK]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008Peptides; Proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13Labelling of peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57572Gastrin releasing peptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/595Gastrins; Cholecystokinins [CCK]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pathology (AREA)
RS20180451A 2013-11-06 2014-10-23 Analog mini-gastrina, naročito za upotrebu u dijagnozi i/ili tretmanu tumora pozitivnog na cck2 receptor RS57137B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20130191807 EP2870972A1 (en) 2013-11-06 2013-11-06 Mini-gastrin analogue, in particular for use in CCK2 receptor positive tumour diagnosis and/or treatment
PCT/EP2014/072697 WO2015067473A1 (en) 2013-11-06 2014-10-23 Mini-gastrin analogue, in particular for use in cck2 receptor positive tumour diagnosis and/or treatment
EP14795569.4A EP3065764B3 (en) 2013-11-06 2014-10-23 Mini-gastrin analogue, in particular for use in cck2 receptor positive tumour diagnosis and/or treatment

Publications (1)

Publication Number Publication Date
RS57137B1 true RS57137B1 (sr) 2018-07-31

Family

ID=49518847

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20180451A RS57137B1 (sr) 2013-11-06 2014-10-23 Analog mini-gastrina, naročito za upotrebu u dijagnozi i/ili tretmanu tumora pozitivnog na cck2 receptor

Country Status (18)

Country Link
US (3) US10130724B2 (sr)
EP (2) EP2870972A1 (sr)
JP (3) JP2017501116A (sr)
KR (2) KR102039930B1 (sr)
CN (1) CN105705159B (sr)
CY (1) CY1120117T1 (sr)
DK (1) DK3065764T6 (sr)
ES (1) ES2670582T7 (sr)
HR (1) HRP20180631T1 (sr)
HU (1) HUE036943T2 (sr)
LT (1) LT3065764T (sr)
NO (1) NO3065764T3 (sr)
PL (1) PL3065764T6 (sr)
PT (1) PT3065764T (sr)
RS (1) RS57137B1 (sr)
SI (1) SI3065764T1 (sr)
TR (1) TR201802723T4 (sr)
WO (1) WO2015067473A1 (sr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2870972A1 (en) 2013-11-06 2015-05-13 Paul Scherrer Institut Mini-gastrin analogue, in particular for use in CCK2 receptor positive tumour diagnosis and/or treatment
WO2018049129A1 (en) * 2016-09-09 2018-03-15 On Target Laboratories, LLC Cholecystokinin 2 receptor targeted nir imaging and use thereof
EP3412303A1 (en) * 2017-06-08 2018-12-12 Medizinische Universität Innsbruck Improved pharmacokinetics and cholecystokinin-2 receptor (cck2r) targeting for diagnosis and therapy
EP3459559A1 (en) * 2017-09-21 2019-03-27 Paul Scherrer Institut Minigastrin derivates, in particular for use in cck2 receptor positive tumour diagnosis and/or treatment
KR20210024048A (ko) 2018-06-22 2021-03-04 가부시키가이샤 준텐 바이오 복합 상태를 갖는 세포 혼합물을 이용한, 면역 관용을 유도하는 항체 및 유도된 림프구, 또한 유도된 림프구를 이용하는 세포 치료제 및 치료법
AU2019288684A1 (en) 2018-06-22 2021-01-21 Junten Bio Co., Ltd. Composition for eliciting infectious immunological tolerance
WO2019245037A1 (ja) 2018-06-22 2019-12-26 株式会社Junten Bio 免疫寛容を誘導する抗体、誘導されたリンパ球、また誘導されたリンパ球を用いる細胞治療剤治療法
EP3868394A1 (en) * 2020-02-20 2021-08-25 Paul Scherrer Institut Mono- and multi-triazolominigastrins for targeting of cck2r-positive neoplasms
WO2021186060A1 (en) 2020-03-20 2021-09-23 Debiopharm International S.A. Radiolabeled gastrin analogue for use in a method of treating and/or imaging cckb receptor positive diseases, in particular pulmonary and extrapulmonary small-cell carcinoma
EP4188455A1 (en) 2020-07-31 2023-06-07 Paul Scherrer Institut Composition comprising a rapalog and a radiolabelled gastrin analogue, in particular for use in the treatment and/or diagnosis of cckb receptor positive cancer or tumors
WO2022023554A1 (en) 2020-07-31 2022-02-03 Paul Scherrer Institut Alpha radiolabeled gastrin analogue and use thereof in methods of treating cckb receptor positive disease
WO2022023539A1 (en) 2020-07-31 2022-02-03 Debiopharm International S.A. Gallium-labeled gastrin analogue and use in a method of imaging cckb-receptor-positive tumors or cancers
WO2022167057A1 (en) 2021-02-02 2022-08-11 Medizinische Universität Innsbruck Improved cholecystokinin-2 receptor (cck2r) targeting for diagnosis and therapy
CN118043482A (zh) 2021-09-28 2024-05-14 保罗·谢勒学院 用于预测被诊断患有癌症的患者对采用靶向cck2-r的化合物进行的治疗和/或成像的响应的方法,以及用于对癌症进行选择性治疗和/或成像的方法的化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650787A (en) 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
EP2870972A1 (en) * 2013-11-06 2015-05-13 Paul Scherrer Institut Mini-gastrin analogue, in particular for use in CCK2 receptor positive tumour diagnosis and/or treatment

Also Published As

Publication number Publication date
EP2870972A1 (en) 2015-05-13
ES2670582T3 (es) 2018-05-31
US11623014B2 (en) 2023-04-11
KR20180094125A (ko) 2018-08-22
NO3065764T3 (sr) 2018-07-21
CY1120117T1 (el) 2018-12-12
SI3065764T1 (en) 2018-05-31
US20190240360A1 (en) 2019-08-08
CN105705159A (zh) 2016-06-22
JP6568618B2 (ja) 2019-08-28
US20160256580A1 (en) 2016-09-08
PL3065764T3 (pl) 2018-07-31
KR102039930B1 (ko) 2019-11-05
CN105705159B (zh) 2021-02-12
EP3065764B3 (en) 2023-10-11
US10953114B2 (en) 2021-03-23
JP2019218364A (ja) 2019-12-26
LT3065764T (lt) 2018-05-10
KR20160070160A (ko) 2016-06-17
ES2670582T7 (es) 2024-05-31
PL3065764T6 (pl) 2024-01-15
JP2018118996A (ja) 2018-08-02
DK3065764T6 (da) 2023-11-06
HUE036943T2 (hu) 2018-08-28
JP6763069B2 (ja) 2020-09-30
HRP20180631T1 (hr) 2018-06-01
US20210145990A1 (en) 2021-05-20
PT3065764T (pt) 2018-03-28
EP3065764A1 (en) 2016-09-14
WO2015067473A1 (en) 2015-05-14
DK3065764T3 (en) 2018-03-12
JP2017501116A (ja) 2017-01-12
TR201802723T4 (tr) 2018-03-21
EP3065764B1 (en) 2018-02-21
US10130724B2 (en) 2018-11-20

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