RS52000B - N-hydroxyamide derivatives and uses thereof - Google Patents

N-hydroxyamide derivatives and uses thereof

Info

Publication number
RS52000B
RS52000B RS20110406A RSP20110406A RS52000B RS 52000 B RS52000 B RS 52000B RS 20110406 A RS20110406 A RS 20110406A RS P20110406 A RSP20110406 A RS P20110406A RS 52000 B RS52000 B RS 52000B
Authority
RS
Serbia
Prior art keywords
alkyl
alkynyl
alkenyl
following
heterocycloalkyl
Prior art date
Application number
RS20110406A
Other languages
Serbian (sr)
Inventor
Dominique Swinnen
Jerome Gonzalez
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of RS52000B publication Critical patent/RS52000B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Derivat N-hidroksiamida u skladu sa formulom Inaznačeno time da:A bude izabrano iz -C(B)- i N; B bude H ili B forma veze sa bilo R5 ili R7; R1 bude izabrano iz sledećih: H, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C8-cikloalkil, heterocikloalkil, aril, heteroaril, C3-C8-cikloalkil C1-C6 alkil, heterocikloalkil C1-C6 alkil, heteroaril C1-C6 alkil, amino i alkoksi;R2 bude izabrano iz sledećih: H, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C8-cikloalkil, heterocikloalkil, alkoksi, aril i heteroaril;R bude izabrano iz sledećih: H, C1-C6 alkil, C2-C6 alkenil i C2-C6 alkinil;R4, R5, R6 i R7 su nezavisno izabrano iz sledećih: H, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil; ili R4 i R7 zajedno formiraju jednu -CH2- vezu;n je broj izabran iz sledećih 1, 2, 3, 4, 5 i 6;Ugljenici (2) i (3) su dva hiralna centra, naznačeno time hiralni centar (2) ima konfiguraciju odabranu iz "S" i "R" i naznačeno time da hiralni centar (3) ima konfigutraciju "S" kao i njihove farmaceutski prihvatljive soli.N-hydroxyamide derivative according to the formula: A is selected from -C (B) - and N; B is H or B forms a bond with either R 5 or R 7; R1 is selected from the following: H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8-cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C3-C8-cycloalkyl C1-C6 alkyl, heterocycloalkyl C1-C6 alkyl , heteroaryl C1-C6 alkyl, amino and alkoxy; R2 is selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8-cycloalkyl, heterocycloalkyl, alkoxy, aryl and heteroaryl; selected from the following: H, C1-C6 alkyl, C2-C6 alkenyl and C2-C6 alkynyl; R4, R5, R6 and R7 are independently selected from the following: H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl ; or R4 and R7 together form one -CH2- bond; n is a number selected from the following 1, 2, 3, 4, 5 and 6; Carbons (2) and (3) are two chiral centers, thus a chiral center (2) has the configuration selected from "S" and "R" and wherein the chiral center (3) has the configuration "S" as well as their pharmaceutically acceptable salts.

RS20110406A 2005-11-24 2006-11-16 N-hydroxyamide derivatives and uses thereof RS52000B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05111228 2005-11-24
US74021105P 2005-11-28 2005-11-28

Publications (1)

Publication Number Publication Date
RS52000B true RS52000B (en) 2012-04-30

Family

ID=36228765

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20110406A RS52000B (en) 2005-11-24 2006-11-16 N-hydroxyamide derivatives and uses thereof

Country Status (6)

Country Link
AT (1) ATE521597T1 (en)
DK (1) DK1951687T3 (en)
ES (1) ES2372420T3 (en)
PT (1) PT1951687E (en)
RS (1) RS52000B (en)
SI (1) SI1951687T1 (en)

Also Published As

Publication number Publication date
DK1951687T3 (en) 2011-10-24
ATE521597T1 (en) 2011-09-15
ES2372420T3 (en) 2012-01-19
PT1951687E (en) 2011-09-06
SI1951687T1 (en) 2011-10-28

Similar Documents

Publication Publication Date Title
RS50980B (en) N-hydroxyamide derivates and use thereof
RS52881B (en) Benzamide compunds useful as histone deacetylase inhibitors
RS52349B (en) 5-substituted quinazolinone derivatives as antitumor agents
HRP20120323T1 (en) Diarylhydantoin compounds
RS50537B (en) Benzimidazole derivative and its use as a ii receptor antagonist
MEP52408A (en) Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
RS52261B (en) Amidophenoxyindazoles useful as inhibitors of c-met
ME00004B (en) Pyrimidine derivatives
RS50606B (en) Substituted morpholine and tiomorpholine derivatives
DE602004008098D1 (en) SUBSTITUTED 2H-Ä1,2,4ÜTRIAZOLOÄ4,3-AÜPYRAZINE AS GSK-3 INHIBITORS
RS51101B (en) Ncv ns3 protease inhibitors
NO20071642L (en) N-Benzenesulfonyl-substituted anilino-pyrimidine analogs
ATE556058T1 (en) 1-(2H)-ISOCHINOLOONE DERIVATIVE
WO2007016392A3 (en) Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
WO2008111441A1 (en) Pharmaceutical composition
RS51471B (en) Biphenyloxyacetic acid derivatives for the treatment of respiratory disease
ATE553106T1 (en) HETEROARYLPYRROLOPYRIDINONES AS KINASE INHIBITORS
SV2009003157A (en) CINAMIDE COMPOUND PROFARMACO
RS52515B (en) Fast dissociating dopamine 2 receptor antagonists
RS54146B1 (en) Cyclopentylacrylamide derivative
EP1674452A4 (en) Novel 4-phenylamino-benzaldoxime derivative and use thereof as mek inhibitor
RS54047B1 (en) Method for producing 4-oxoquinoline compound
HRP20050390A2 (en) Substituted benzoxazinones and uses thereof
CO5601030A2 (en) DERIVATIVES OF QUINOLINONA / BENZOXAZINONA AND USES OF THE SAME
WO2008136444A1 (en) Fused heterocyclic derivative