RS52000B - N-hydroxyamide derivatives and uses thereof - Google Patents
N-hydroxyamide derivatives and uses thereofInfo
- Publication number
- RS52000B RS52000B RS20110406A RSP20110406A RS52000B RS 52000 B RS52000 B RS 52000B RS 20110406 A RS20110406 A RS 20110406A RS P20110406 A RSP20110406 A RS P20110406A RS 52000 B RS52000 B RS 52000B
- Authority
- RS
- Serbia
- Prior art keywords
- alkyl
- alkynyl
- alkenyl
- following
- heterocycloalkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Derivat N-hidroksiamida u skladu sa formulom Inaznačeno time da:A bude izabrano iz -C(B)- i N; B bude H ili B forma veze sa bilo R5 ili R7; R1 bude izabrano iz sledećih: H, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C8-cikloalkil, heterocikloalkil, aril, heteroaril, C3-C8-cikloalkil C1-C6 alkil, heterocikloalkil C1-C6 alkil, heteroaril C1-C6 alkil, amino i alkoksi;R2 bude izabrano iz sledećih: H, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C8-cikloalkil, heterocikloalkil, alkoksi, aril i heteroaril;R bude izabrano iz sledećih: H, C1-C6 alkil, C2-C6 alkenil i C2-C6 alkinil;R4, R5, R6 i R7 su nezavisno izabrano iz sledećih: H, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil; ili R4 i R7 zajedno formiraju jednu -CH2- vezu;n je broj izabran iz sledećih 1, 2, 3, 4, 5 i 6;Ugljenici (2) i (3) su dva hiralna centra, naznačeno time hiralni centar (2) ima konfiguraciju odabranu iz "S" i "R" i naznačeno time da hiralni centar (3) ima konfigutraciju "S" kao i njihove farmaceutski prihvatljive soli.N-hydroxyamide derivative according to the formula: A is selected from -C (B) - and N; B is H or B forms a bond with either R 5 or R 7; R1 is selected from the following: H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8-cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C3-C8-cycloalkyl C1-C6 alkyl, heterocycloalkyl C1-C6 alkyl , heteroaryl C1-C6 alkyl, amino and alkoxy; R2 is selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8-cycloalkyl, heterocycloalkyl, alkoxy, aryl and heteroaryl; selected from the following: H, C1-C6 alkyl, C2-C6 alkenyl and C2-C6 alkynyl; R4, R5, R6 and R7 are independently selected from the following: H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl ; or R4 and R7 together form one -CH2- bond; n is a number selected from the following 1, 2, 3, 4, 5 and 6; Carbons (2) and (3) are two chiral centers, thus a chiral center (2) has the configuration selected from "S" and "R" and wherein the chiral center (3) has the configuration "S" as well as their pharmaceutically acceptable salts.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05111228 | 2005-11-24 | ||
| US74021105P | 2005-11-28 | 2005-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS52000B true RS52000B (en) | 2012-04-30 |
Family
ID=36228765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20110406A RS52000B (en) | 2005-11-24 | 2006-11-16 | N-hydroxyamide derivatives and uses thereof |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | ATE521597T1 (en) |
| DK (1) | DK1951687T3 (en) |
| ES (1) | ES2372420T3 (en) |
| PT (1) | PT1951687E (en) |
| RS (1) | RS52000B (en) |
| SI (1) | SI1951687T1 (en) |
-
2006
- 2006-11-16 AT AT06819550T patent/ATE521597T1/en active
- 2006-11-16 SI SI200631116T patent/SI1951687T1/en unknown
- 2006-11-16 ES ES06819550T patent/ES2372420T3/en active Active
- 2006-11-16 RS RS20110406A patent/RS52000B/en unknown
- 2006-11-16 PT PT06819550T patent/PT1951687E/en unknown
- 2006-11-16 DK DK06819550.2T patent/DK1951687T3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DK1951687T3 (en) | 2011-10-24 |
| ATE521597T1 (en) | 2011-09-15 |
| ES2372420T3 (en) | 2012-01-19 |
| PT1951687E (en) | 2011-09-06 |
| SI1951687T1 (en) | 2011-10-28 |
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