Jedinjenje formule (I), ili njegova farmaceutski prihvatljiva so i/ili solvat (uključujući hidrat);gdeR1 je CH3, SCH3, SCH2CH3, CH2CH3, H ili CH2SCH3; R1aje CH3 ili CH2CH3;R2 je heteroaril, heterociklil, aril, ili karbociklil; R3 je heteroaril, heterociklil, aril, carbociklil ili R7;R7je (C1-C6)alkil po izboru supstituisan jednim ili više supstituenata nezavisno odabranim od OH, halo, NR5R6, (C1-C8)alkoksi, -S(O)p(C1-C8)alkil, CO2H, CONR5R6, heteroaril, heterociklil, aril, karbociklil, ariloksi, karbocikliloksi, heteroariloksi i heterocikliloksi; pjeO, 1 ili 2;R5 i R6 su svaki nezavisno odabrani od H i (C1-C4)alkil, dati (C1-C4) alkil je po izboru supstituisan jednim ili više supstituenata nezavisno odabranim od OH i halo, ili R5 i R6, zajeno sa azotom za koji su vezani formiraju piperazinil, piperidinil, morfolinil ili pirolidinil grupu, dati piperazinil, piperidinil, morfolinil i pirolidinil je svaki po izboru supstitusan jednim ili više OH;"aril" označava fenil ili naftil, dati fenil ili naftil je po izboru supstituisan jednim ili više supstituenata nezavisno odabranih od halo, -CN, -CO2H, ON, CONR5R6, R7 i R8; R8 je odabran od (C1-C6)alkil, (C1-C6)alkoksi, -CO2(C1-C6)alkil, -S(O)p(C1-C6)alkil, -CO(C1-C6)alkil i (C3-C7)cikloalkil;svaki R5 je po izboru supstituisan jednim ili više supstituenata nezavisno odabranih od: (C1-C6)alkoksi po izboru supstituisan jednim ili više supstituenata nezavisno selected from OH, halo, CO2H, CONR5R6 i NR5R6.-S(O)p(C1-C6)alkil po izboru supstituisan jednom ili više supstituenata nezavisno odabranih od OH, halo, CO2H, CONR5R6 i NR5R6,OH,halo,NR5R6,CO2H,CONR5R6, iR9;R9 je heteroaril2, heterociklil2, aril2, karbociklil2, aril2oksi, carbociklil2oksi, heteroaril2oksi ili heterociklil2oksi;"aril2", označava fenil ili naftil, dati fenil ili naftil je po izboru supstituisan jednim ili višesupstituenata nezavisno odabranih od halo, -CN, CO2H, OH i CONR5R6;"karbociklil" označava mono ili bicikličan, zasićen ili delimično nezasićen prstenasti sistemkoji sadrži 3 do 10 atoma ugljenika u prstenu, po izboru supstituisan jednim ili višesupstituenata nezavisno odbranih od halo, -CN, -CO2H, OH, CONR5R6, R8 i R9."karbociklil2" označava mono ili bicikličan, zasićen ili delimično nezasićen prstenastisistem sa 3 do 10 atoma ugljenika u prstenu, po izboru supstituisan jednim ili višesupstituenata nezavisno odabrnaih od halo, -CN, -CO2H, OH i CONR5R6;svaki "heterociklil", i "heterociklil2" nezavisno, označava 3- do 10-članu, zasićenu ilidelimično nezaišećnu, mono ili bicikličnu grupu sa 1 do 4 heteroatoma u prstenu,nezavisno odabranih od N, O, i S,svaki "heteroaril", i svaki "heteroaril2", nezavisno, označava 5 do 10 članu, mono ili bicikličnu, aromatičnu grupu koja sadrži od 1 do A compound of formula (I), or a pharmaceutically acceptable salt and / or solvate thereof (including hydrate), wherein R1 is CH3, SCH3, SCH2CH3, CH2CH3, H or CH2SCH3; R 1 is CH 3 or CH 2 CH 3; R 2 is heteroaryl, heterocyclyl, aryl, or carbocyclyl; R3 is heteroaryl, heterocyclyl, aryl, carbocyclyl or R7; R7 is (C1-C6) alkyl optionally substituted by one or more substituents independently selected from OH, halo, NR5R6, (C1-C8) alkoxy, -S (O) p (C1 -C8) alkyl, CO2H, CONR5R6, heteroaryl, heterocyclyl, aryl, carbocyclyl, aryloxy, carbocyclyloxy, heteroaryloxy and heterocyclyloxy; p is 0, 1 or 2; R 5 and R 6 are each independently selected from H and (C 1 -C 4) alkyl, the given (C 1 -C 4) alkyl is optionally substituted by one or more substituents independently selected from OH and halo, or R 5 and R 6. together with the nitrogen to which they are attached form a piperazinyl, piperidinyl, morpholinyl or pyrrolidinyl group, the piperazinyl, piperidinyl, morpholinyl and pyrrolidinyl each optionally substituted by one or more OH; "aryl" means phenyl or naphthyl, the phenyl or naphthyl optionally substituted by one or more substituents independently selected from halo, -CN, -CO2H, ON, CONR5R6, R7 and R8; R8 is selected from (C1-C6) alkyl, (C1-C6) alkoxy, -CO2 (C1-C6) alkyl, -S (O) p (C1-C6) alkyl, -CO (C1-C6) alkyl and ( C3-C7 cycloalkyl; each R5 is optionally substituted by one or more substituents independently selected from: (C1-C6) alkoxy optionally substituted by one or more substituents independently selected from OH, halo, CO2H, CONR5R6 and NR5R6.-S (O ) p (C1-C6) alkyl optionally substituted by one or more substituents independently selected from OH, halo, CO2H, CONR5R6 and NR5R6, OH, halo, NR5R6, CO2H, CONR5R6, iR9; R9 is heteroaryl2, heterocyclyl2, aryl2, carbocyclyl "aryl2", denotes phenyl or naphthyl, the phenyl or naphthyl optionally substituted by one or more substituents independently selected from halo, -CN, CO2H, OH and CONR5R6; "carbocyclic, or" carbocyclic, or "carbocyclic"; saturated or partially unsaturated ring systems containing from 3 to 10 carbon atoms in the ring, optionally substituted by one or more substituents independently selected from of halo, -CN, -CO2H, OH, CONR5R6, R8 and R9. "carbocyclyl2" means a mono or bicyclic, saturated or partially unsaturated ring system with 3 to 10 carbon atoms in the ring optionally substituted by one or more substituents independently selected from halo , -CN, -CO2H, OH and CONR5R6; each "heterocyclyl", and "heterocyclyl2" independently, denotes a 3- to 10-membered, saturated ilidelimically unsaturated, mono or bicyclic group with 1 to 4 ring heteroatoms independently selected from N , O, and S, each "heteroaryl", and each "heteroaryl2" independently denotes a 5 to 10 member, mono or bicyclic, aromatic group containing from 1 to