RS50058B - Kompozicije oksikodona sa kontrolisanim oslobađanjem - Google Patents
Kompozicije oksikodona sa kontrolisanim oslobađanjemInfo
- Publication number
- RS50058B RS50058B YUP-2005/0413A YU41305A RS50058B RS 50058 B RS50058 B RS 50058B YU 41305 A YU41305 A YU 41305A RS 50058 B RS50058 B RS 50058B
- Authority
- RS
- Serbia
- Prior art keywords
- oxycodone
- controlled release
- released
- salts
- hours
- Prior art date
Links
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 title abstract 7
- 238000013270 controlled release Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 229960002085 oxycodone Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- BQNSLJQRJAJITR-UHFFFAOYSA-N 1,1,2-trichloro-1,2-difluoroethane Chemical compound FC(Cl)C(F)(Cl)Cl BQNSLJQRJAJITR-UHFFFAOYSA-N 0.000 abstract 1
- 239000004925 Acrylic resin Substances 0.000 abstract 1
- 229920000178 Acrylic resin Polymers 0.000 abstract 1
- 239000012062 aqueous buffer Substances 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960003617 oxycodone hydrochloride Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Upotreba materijala matrice za kontrolisano oslobađanje koja se sastoji od akrilne smole, za proizvodnju formulacije soli oksikodona sa kontrolisanim oslobađanjem za oralnu primenu kod humanih paci j enata, forrnulacij a se sastoj i od soli oksikodona u količinama koj e su ekvi valentne 10 mg do 160 mg oksikodon hidrohlorida i upotreblj iva je za ublažavanje bola li ravnotežnom stanju posle ponovlj enog davanj a u 12-časovnim intervalima, gde pomenuta formulacija ima in vitro brzinu rastvaranja koja merena Postupkom sa lopaticama (USP Paddle Method) pri 100 oum u 900 ml vodenog pufera (pH između 1.6 i 7.2) na 37oC je između 12.5% i 42.5% (težinskih) soli oksikodona oslobođene posle jednog sata, između 25% i 56% (težinskih) soli oksikodona oslobođene posle 2 sata, između' 45% i 75% (težinskih) soli oksikodona oslobođene posle 4 sata i između 55% i 85% (težinskih) soli oksikodna i oslobođene posle 6 sati. Prijava sadrži još 8 zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1014692A | 1992-11-25 | 1992-11-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU20050413A YU20050413A (sh) | 2006-08-17 |
| RS50058B true RS50058B (sr) | 2008-11-28 |
Family
ID=37616752
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-2005/0411A RS50057B (sr) | 1992-11-25 | 1993-05-21 | Komopzicije oksikodona sa kontrolisanim oslobađanjem |
| YUP-2005/0413A RS50058B (sr) | 1992-11-25 | 1993-05-21 | Kompozicije oksikodona sa kontrolisanim oslobađanjem |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-2005/0411A RS50057B (sr) | 1992-11-25 | 1993-05-21 | Komopzicije oksikodona sa kontrolisanim oslobađanjem |
Country Status (2)
| Country | Link |
|---|---|
| ME (6) | MEP47708A (sr) |
| RS (2) | RS50057B (sr) |
-
1993
- 1993-05-21 RS YUP-2005/0411A patent/RS50057B/sr unknown
- 1993-05-21 ME MEP-477/08A patent/MEP47708A/xx unknown
- 1993-05-21 ME MEP-480/08A patent/MEP48008A/xx unknown
- 1993-05-21 ME MEP-475/08A patent/MEP47508A/xx unknown
- 1993-05-21 ME MEP-478/08A patent/MEP47808A/xx unknown
- 1993-05-21 ME MEP-476/08A patent/MEP47608A/xx unknown
- 1993-05-21 RS YUP-2005/0413A patent/RS50058B/sr unknown
- 1993-05-21 ME MEP-479/08A patent/MEP47908A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MEP47808A (en) | 2011-02-10 |
| MEP47608A (en) | 2011-02-10 |
| MEP48008A (en) | 2011-02-10 |
| MEP47908A (en) | 2011-02-10 |
| MEP47708A (en) | 2011-02-10 |
| YU20050413A (sh) | 2006-08-17 |
| RS50057B (sr) | 2008-11-28 |
| YU20050411A (sh) | 2006-08-17 |
| MEP47508A (en) | 2011-02-10 |
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