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Application filed by Momir Mikov, Vida Jakovljević, Ksenija Kuhajda, Slavko Kevrešan, Vasović, Velibor,filedCriticalMomir Mikov
Priority to YUP-213/04ApriorityCriticalpatent/RS21304A/en
Publication of RS21304ApublicationCriticalpatent/RS21304A/en
Invention solves the problem of modification of permeability for drugs and poisons through blood-brain barrier through the original procedure for application of bile acids and derivates thereof as blood-brain barrier permeability modifiers.It is unknown that bile acids and derivates thereof administered prior or at the same time with drugs and poisons, modify the passage to drugs and poisons through the blood-brain barrier. Subject matter of the invention consists in, that during application of the solution of bile acid salts and derivates thereof, as well, through the blood-brain barrier. In our work, due to modification of passage of drugs and poisons through blood-brain barrier synthesized are various derivates of natural bile acids.
YUP-213/04A2004-03-102004-03-10Bile acids and derivates thereof as blood-brain barrier permeability modifiers for drugs and poisons
RS21304A
(en)
Malonamide derived compounds, gamma-secretase inhibitors; Preparation process; pharmaceutical composition; and its use in the treatment of Alzheimer's disease.