RO98060B1 - Process for obtaining bismuth m-cumarate - Google Patents
Process for obtaining bismuth m-cumarateInfo
- Publication number
- RO98060B1 RO98060B1 RO128646A RO12864687A RO98060B1 RO 98060 B1 RO98060 B1 RO 98060B1 RO 128646 A RO128646 A RO 128646A RO 12864687 A RO12864687 A RO 12864687A RO 98060 B1 RO98060 B1 RO 98060B1
- Authority
- RO
- Romania
- Prior art keywords
- bismuth
- average
- treatment
- gastric ulcer
- coumaric acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229910052797 bismuth Inorganic materials 0.000 title abstract 2
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 title abstract 2
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 2
- 201000005917 gastric ulcer Diseases 0.000 abstract 2
- KKSDGJDHHZEWEP-UHFFFAOYSA-N m-hydroxycinnamic acid Natural products OC(=O)C=CC1=CC=CC(O)=C1 KKSDGJDHHZEWEP-UHFFFAOYSA-N 0.000 abstract 2
- KKSDGJDHHZEWEP-SNAWJCMRSA-N trans-3-coumaric acid Chemical compound OC(=O)\C=C\C1=CC=CC(O)=C1 KKSDGJDHHZEWEP-SNAWJCMRSA-N 0.000 abstract 2
- 230000002467 anti-pepsin effect Effects 0.000 abstract 1
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 229940049676 bismuth hydroxide Drugs 0.000 abstract 1
- -1 bismuth phenylpropane compound Chemical class 0.000 abstract 1
- TZSXPYWRDWEXHG-UHFFFAOYSA-K bismuth;trihydroxide Chemical compound [OH-].[OH-].[OH-].[Bi+3] TZSXPYWRDWEXHG-UHFFFAOYSA-K 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000013558 reference substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Abstract
Prezenta inventie se refera la un procedeu de obtinere a unui compus fenilpropanic cu bismut cu efect antiseptic, utilizabil în tratamentul ulcerului gastric. Produsul obtinut este m-cumaratul de bismut, obtinut prin reactia dintre acidul m-cumaric si hidroxidul de bismut, cu un continut mediu de Bi+ de 53,10%. Activitatea antipeptica, stabilita dupa un model experimental in vitro, este, în medie, de 68,3%, de aproximativ 3 ori mai mare fata de cea stabilita pentru acidul m-cumaric si substantele de referinta. Avantajele oferite de prezenta inventie constau în faptul ca largeste gama produselor terapeutice destinate tratamentului ulcerului gastric, iar procedeul de obtinere este usor de realizat si foloseste reactivi accesibili.The present invention relates to a process for the preparation of a bismuth phenylpropane compound having antiseptic effect, useful in the treatment of gastric ulcer. The product obtained is bismuth mumarate, obtained by reacting m-coumaric acid with bismuth hydroxide, with an average Bi + content of 53.10%. Anti-peptic activity, determined by an in vitro experimental model, is on average 68.3%, approximately 3 times higher than that established for m-coumaric acid and reference substances. The advantages of the present invention consist in the fact that it broadens the range of therapeutic products for the treatment of gastric ulcer, and the process of obtaining it is easy to achieve and uses accessible reagents.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO128646A RO98060B1 (en) | 1987-06-16 | 1987-06-16 | Process for obtaining bismuth m-cumarate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO128646A RO98060B1 (en) | 1987-06-16 | 1987-06-16 | Process for obtaining bismuth m-cumarate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO98060B1 true RO98060B1 (en) | 1989-10-30 |
Family
ID=40906178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO128646A RO98060B1 (en) | 1987-06-16 | 1987-06-16 | Process for obtaining bismuth m-cumarate |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO98060B1 (en) |
-
1987
- 1987-06-16 RO RO128646A patent/RO98060B1/en unknown
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