RO97053B1 - Process for preparing n-benzoylurea compounds - Google Patents
Process for preparing n-benzoylurea compoundsInfo
- Publication number
- RO97053B1 RO97053B1 RO125776A RO12577686A RO97053B1 RO 97053 B1 RO97053 B1 RO 97053B1 RO 125776 A RO125776 A RO 125776A RO 12577686 A RO12577686 A RO 12577686A RO 97053 B1 RO97053 B1 RO 97053B1
- Authority
- RO
- Romania
- Prior art keywords
- group
- hydrogen atom
- atom
- unsubstituted
- trifluoromethyl
- Prior art date
Links
- HRYILSDLIGTCOP-UHFFFAOYSA-N N-benzoylurea Chemical class NC(=O)NC(=O)C1=CC=CC=C1 HRYILSDLIGTCOP-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la un procedeu de obtinere a unor derivati de N-benzoiluree cu actiune antitumorala, cu formula generala (vezi formula în descriere) în care X este un atom de hidrogen, un atom de halogen sau o grupa nitro, n este un numar întreg de la 1 la 3 si O este (vezi formula) în care Y1 este o grupa alchil nesubstituita sau substituita sau o grupa alcoxi sau alcoxicarbonil cu jumatatea sa alchil nesubstituita sau substituita; Y2 este un atom de hidrogen, un atom de halogen, o grupa nitro-, o grupa alchil nesubstituita sau o grupa alcoxi sau alcoxicarbonil cu jumatatea sa de alchil nesubstituita sau substituita; Z este un atom de hidrogen, un atom de halogen, o grupa trifluormetil sau o grupa nitro si fiecare din A si B este =CH - sau un atom de azot, cu mentinerea ca unul dintre A si B este =CH- si celalalt este un atom de azot cu mentiunea (1) ca daca Q este (vezi formula în descriere) în care daca X este un atom de hidrogen si Y1 este o grupa alchil Z nu este un atom de hidrogen, un atom de halogen si nici o grupa trifluormetil (2) si daca Q este în care A este un atom de azot si Y1 este o grupa trifluormetil Y2, este altceva decât un atom de hidrogen.The invention relates to a process for the preparation of N-benzoylureas derivatives having antitumor action of the general formula (wherein X is a hydrogen atom, a halogen atom or a nitro group, n is a number an integer of 1 to 3, and O is (see formula) wherein Y1 is an unsubstituted or substituted alkyl group or an alkoxy or alkoxycarbonyl group with its unsubstituted or substituted alkyl moiety; Y2 is a hydrogen atom, a halogen atom, a nitro group, an unsubstituted alkyl group or an alkoxy or alkoxycarbonyl group with its unsubstituted or substituted alkyl moiety; Z is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and each of A and B is = CH- or a nitrogen atom, with the maintenance that one of A and B is = CH- and the other is a nitrogen atom with the mention (1) that if Q is (see formula in the description) wherein if X is a hydrogen atom and Y1 is an alkyl group Z is not a hydrogen atom, a halogen atom and no group trifluoromethyl (2) and if Q is wherein A is a nitrogen atom and Y1 is a trifluoromethyl group Y2, is other than a hydrogen atom.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO125776A RO97053B1 (en) | 1986-12-09 | 1986-12-09 | Process for preparing n-benzoylurea compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO125776A RO97053B1 (en) | 1986-12-09 | 1986-12-09 | Process for preparing n-benzoylurea compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO97053B1 true RO97053B1 (en) | 1989-06-02 |
Family
ID=40905381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO125776A RO97053B1 (en) | 1986-12-09 | 1986-12-09 | Process for preparing n-benzoylurea compounds |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO97053B1 (en) |
-
1986
- 1986-12-09 RO RO125776A patent/RO97053B1/en unknown
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