RO95061B1 - Peptide preparation process - Google Patents

Peptide preparation process

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Publication number
RO95061B1
RO95061B1 RO115569A RO11556984A RO95061B1 RO 95061 B1 RO95061 B1 RO 95061B1 RO 115569 A RO115569 A RO 115569A RO 11556984 A RO11556984 A RO 11556984A RO 95061 B1 RO95061 B1 RO 95061B1
Authority
RO
Romania
Prior art keywords
arg
gln
ile
asn
leu
Prior art date
Application number
RO115569A
Other languages
Romanian (ro)
Inventor
Bohlen Peter
Ernest Brazeau Paul
Stephen Esch Frederick
Chikwan Ling Nicholas
Busse Wehrenberg William
Charles Louis Guillemin Roger
Original Assignee
The Salk Institute For Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Salk Institute For Biological Studies filed Critical The Salk Institute For Biological Studies
Priority to RO115569A priority Critical patent/RO95061B1/en
Publication of RO95061B1 publication Critical patent/RO95061B1/en

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Procedeul, conform inventiei, se refera la obtinerea de peptide cu formula: H-Tir-Ala-Asp-Ala-Ile-Fe-Tr-Asn-Ser-Tir-Arg-Lis-R13-Leu-Gli-Gln-Leu-Ser-Ana-Arg-Lis-Leu-Leu-Gln-Asp-Ile-Met-R28-Arg-Gln-Gln-Gli-Glu-Arg-Asn-Gln-Glu-Gln-Gli-Ala-R41-Val-Arg-Leu- unde R13 este Val sau Ile; R28 este Ser sau Asn, iar R41 este Arg sau Lis, extrem de eficiente în stimularea eliberarii GH (hormonul de crestere) pituitar la mamifere, deoarece ele sînt reproduceri ale factorului natural de eliberare (hormon)-hipotalamusului la specii particuloare, adica porcine, bovine, caprine si ovine.The process according to the invention relates to the production of peptides of the formula: H-Tyr-Ala-Asp-Ala-Ile-Fe-Tr-Asn-Ser-Tyr-Arg- Ana-Arg-Ser-Lys-Leu-Leu-Gln-Asp-Ile-Met-R28-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu-Gln-Gly-Ala-R41-Val- Arg-Leu- where R13 is Val or Ile; R28 is Ser or Asn, and R41 is Arg or Lis, highly effective in stimulating the release of pituitary GH (growth hormone) in mammals, since they are replications of the natural (triglyceride) -charothoram release factor in particular species, i.e., porcine, cattle, sheep and goats.

RO115569A 1984-08-28 1984-08-28 Peptide preparation process RO95061B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RO115569A RO95061B1 (en) 1984-08-28 1984-08-28 Peptide preparation process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RO115569A RO95061B1 (en) 1984-08-28 1984-08-28 Peptide preparation process

Publications (1)

Publication Number Publication Date
RO95061B1 true RO95061B1 (en) 1988-08-17

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ID=40904574

Family Applications (1)

Application Number Title Priority Date Filing Date
RO115569A RO95061B1 (en) 1984-08-28 1984-08-28 Peptide preparation process

Country Status (1)

Country Link
RO (1) RO95061B1 (en)

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