RO95045B1 - Procedeu de extractie si purificare a fenoximetilpenicilinei - Google Patents
Procedeu de extractie si purificare a fenoximetilpenicilineiInfo
- Publication number
- RO95045B1 RO95045B1 RO123032A RO12303286A RO95045B1 RO 95045 B1 RO95045 B1 RO 95045B1 RO 123032 A RO123032 A RO 123032A RO 12303286 A RO12303286 A RO 12303286A RO 95045 B1 RO95045 B1 RO 95045B1
- Authority
- RO
- Romania
- Prior art keywords
- purifying
- extracting
- phenoxymethyl penicillin
- phenoxymethylpenicillin
- extracted
- Prior art date
Links
- 229930195708 Penicillin V Natural products 0.000 title abstract 3
- 229940056367 penicillin v Drugs 0.000 title abstract 3
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 abstract 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 239000012670 alkaline solution Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 235000015320 potassium carbonate Nutrition 0.000 abstract 1
- 235000011118 potassium hydroxide Nutrition 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 235000017550 sodium carbonate Nutrition 0.000 abstract 1
- 235000011121 sodium hydroxide Nutrition 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Procedeu de extractie si purificare a fenoximetilpenicilinei ce consta în aceea ca solutia apoasa obtinuta dupa filtrarea lichidului de cultura ce contine fenoximetilpenicilina se extrage, în doua faze, în acetat de butil, la pH=1,8...2,2, dupa care solutia de acetat de butil ce contine substanta activa se extrage cu o solutie apoasa alcalina aleasa dintre K2CO3, Na2CO3, NaOH sau KOH, la pH=7,0...7,1, apoi solutia alcalina se amesteca cu alcool butilic si se evapora în vid la 25...45 degree C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO123032A RO95045B1 (ro) | 1986-04-18 | 1986-04-18 | Procedeu de extractie si purificare a fenoximetilpenicilinei |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO123032A RO95045B1 (ro) | 1986-04-18 | 1986-04-18 | Procedeu de extractie si purificare a fenoximetilpenicilinei |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO95045A2 RO95045A2 (ro) | 1988-08-15 |
| RO95045B1 true RO95045B1 (ro) | 1988-08-16 |
Family
ID=20119288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO123032A RO95045B1 (ro) | 1986-04-18 | 1986-04-18 | Procedeu de extractie si purificare a fenoximetilpenicilinei |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO95045B1 (ro) |
-
1986
- 1986-04-18 RO RO123032A patent/RO95045B1/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO95045A2 (ro) | 1988-08-15 |
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