RO89832B - Process for preserving diphtero-tetanic-pertussis vaccine - Google Patents

Process for preserving diphtero-tetanic-pertussis vaccine

Info

Publication number
RO89832B
RO89832B RO113661A RO11366184A RO89832B RO 89832 B RO89832 B RO 89832B RO 113661 A RO113661 A RO 113661A RO 11366184 A RO11366184 A RO 11366184A RO 89832 B RO89832 B RO 89832B
Authority
RO
Romania
Prior art keywords
pertussis vaccine
diphtero
tetanic
preserving
tetanus
Prior art date
Application number
RO113661A
Other languages
Romanian (ro)
Other versions
RO89832A (en
Inventor
Zoltan Csizer
Karoly Sikos
Laszlo Bacskai
Istvan Joo
Peterne Niedermayer
Lajos Rethy
Jozsef Zsidai
Original Assignee
Human Oltosnysgtermelo Es Kutato Intezet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Oltosnysgtermelo Es Kutato Intezet filed Critical Human Oltosnysgtermelo Es Kutato Intezet
Publication of RO89832A publication Critical patent/RO89832A/en
Publication of RO89832B publication Critical patent/RO89832B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Procedeul de conservare a vaccinului diftero-tetanic-pertussis, conform inventiei, consta în aceea ca fiecare antigen se absoarbe, la pH acid, pe un suport adsorbant mineral, se combina solutiile obtinute, se adauga un material de producctie si un conservant uzual, se adice amestecul la pH 5...6, dupa care se mentine la -35 degree C timp de lo h se ridica temperatura de -35 degree C la 20 degree C pe intervalul de 8 h în continuare de la 20 degree C la 35 degree C pe intervalul de 10 h.The process for conserving the diphtheria-tetanus-pertussis vaccine according to the invention consists in that each antigen is absorbed at an acidic pH on a mineral adsorbent support, combining the obtained solutions, adding a production material and a preservative usually, i.e., the mixture at a pH of 5 ... 6, then maintaining it at -35 ° C for a time of -35 ° C to 20 ° C for a further 8 hours from 20 ° C to 35 ° C C over 10 h.

RO113661A 1983-02-22 1984-02-20 Process for preserving diphtero-tetanic-pertussis vaccine RO89832B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU367783 1983-02-22

Publications (2)

Publication Number Publication Date
RO89832A RO89832A (en) 1987-01-30
RO89832B true RO89832B (en) 1987-01-31

Family

ID=10965021

Family Applications (1)

Application Number Title Priority Date Filing Date
RO113661A RO89832B (en) 1983-02-22 1984-02-20 Process for preserving diphtero-tetanic-pertussis vaccine

Country Status (2)

Country Link
RO (1) RO89832B (en)
SE (1) SE463958B (en)

Also Published As

Publication number Publication date
SE8400934L (en) 1984-08-23
SE463958B (en) 1991-02-18
RO89832A (en) 1987-01-30
SE8400934D0 (en) 1984-02-21

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