RO86718B1 - Procedeu de obtinere a nistatinei solubile si injectabile - Google Patents
Procedeu de obtinere a nistatinei solubile si injectabileInfo
- Publication number
- RO86718B1 RO86718B1 RO110707A RO11070783A RO86718B1 RO 86718 B1 RO86718 B1 RO 86718B1 RO 110707 A RO110707 A RO 110707A RO 11070783 A RO11070783 A RO 11070783A RO 86718 B1 RO86718 B1 RO 86718B1
- Authority
- RO
- Romania
- Prior art keywords
- injectable
- ratio
- ethyl ether
- nistatine
- sodium
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- VQOXZBDYSJBXMA-RKEBNKJGSA-N nystatin a1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@@H]1OC1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)CC(O)CC(O)CC(O)CCC(O)C(O)C[C@](O)(CC(O)C2C(O)=O)OC2C1 VQOXZBDYSJBXMA-RKEBNKJGSA-N 0.000 abstract 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 abstract 2
- 238000005406 washing Methods 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 235000010344 sodium nitrate Nutrition 0.000 abstract 1
- 239000004317 sodium nitrate Substances 0.000 abstract 1
- 229940080313 sodium starch Drugs 0.000 abstract 1
- 238000005063 solubilization Methods 0.000 abstract 1
- 230000007928 solubilization Effects 0.000 abstract 1
- 238000001291 vacuum drying Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la un procedeu de obtinere a nistatinei solubile si injectabile, care se caracterizeaza prin aceea ca nistatina se purifica prin solubilizare în dimetilformamida si precipitare în eter etilic într-un raport de 1:3:5 dupa care se obtine nistatina sodica prin reactia de schimb ionicc, în mediu de etanol cu 2-etilhexilhanoatul de sodiu într-un raport de 1 : 3, spalarea cu eter etilic într-un raport de 1 : 3, spalarea cu eter etilic, esorarea si uscarea la vid la cel mult 40 degree C dupa care nistatina sodica se solubilizeaza în apa sterila si apirogena în concentratie de 5...10%, se filtreaza, se usuca prin liofilizare.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO110707A RO86718B1 (ro) | 1983-04-20 | 1983-04-20 | Procedeu de obtinere a nistatinei solubile si injectabile |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO110707A RO86718B1 (ro) | 1983-04-20 | 1983-04-20 | Procedeu de obtinere a nistatinei solubile si injectabile |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO86718A2 RO86718A2 (ro) | 1985-04-17 |
| RO86718B1 true RO86718B1 (ro) | 1985-05-01 |
Family
ID=20112954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO110707A RO86718B1 (ro) | 1983-04-20 | 1983-04-20 | Procedeu de obtinere a nistatinei solubile si injectabile |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO86718B1 (ro) |
-
1983
- 1983-04-20 RO RO110707A patent/RO86718B1/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO86718A2 (ro) | 1985-04-17 |
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