RO83630B - Process for preparing 11 beta, 21-dihydroxy-2'-methyl-5' beta-1, 4-pregnadieno (16,17-d)-oxazole-3,20-dione - Google Patents

Process for preparing 11 beta, 21-dihydroxy-2'-methyl-5' beta-1, 4-pregnadieno (16,17-d)-oxazole-3,20-dione

Info

Publication number
RO83630B
RO83630B RO106089A RO10608981A RO83630B RO 83630 B RO83630 B RO 83630B RO 106089 A RO106089 A RO 106089A RO 10608981 A RO10608981 A RO 10608981A RO 83630 B RO83630 B RO 83630B
Authority
RO
Romania
Prior art keywords
beta
oxazole
dione
dihydroxy
methyl
Prior art date
Application number
RO106089A
Other languages
Romanian (ro)
Other versions
RO83630A (en
Inventor
Alfred Weber
Mario Kennecke
Rudolf Muller
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of RO83630A publication Critical patent/RO83630A/en
Publication of RO83630B publication Critical patent/RO83630B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/02—Dehydrogenating; Dehydroxylating
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0068—Nitrogen and oxygen at position 16(17)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for preparing 11 beta ,21-dihydroxy-2'-methyl-5' beta H-1,4-pregnadieno(16,17-d)-oxazole-3,20-dione, comprises fermenting 11 beta ,21-dihydroxy-2'-methyl-5' beta H-4-pregneno (16,17-d)-oxazole-3,20-dione with a living culture of Arthrobacter simplex.
RO106089A 1980-12-23 1981-12-23 Process for preparing 11 beta, 21-dihydroxy-2'-methyl-5' beta-1, 4-pregnadieno (16,17-d)-oxazole-3,20-dione RO83630B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3049401 1980-12-23

Publications (2)

Publication Number Publication Date
RO83630A RO83630A (en) 1984-06-21
RO83630B true RO83630B (en) 1984-08-30

Family

ID=6120492

Family Applications (1)

Application Number Title Priority Date Filing Date
RO106089A RO83630B (en) 1980-12-23 1981-12-23 Process for preparing 11 beta, 21-dihydroxy-2'-methyl-5' beta-1, 4-pregnadieno (16,17-d)-oxazole-3,20-dione

Country Status (10)

Country Link
US (1) US4431732A (en)
EP (1) EP0055832B1 (en)
JP (1) JPS57170197A (en)
AT (1) ATE18257T1 (en)
DD (1) DD202050A5 (en)
DE (1) DE3173923D1 (en)
DK (1) DK157891C (en)
FI (1) FI72144C (en)
HU (1) HU186454B (en)
RO (1) RO83630B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054810B1 (en) * 1980-12-23 1986-07-30 Schering Aktiengesellschaft Process for the preparation of 3-oxo-delta-1,4-steroids
JPS6145294A (en) * 1984-08-09 1986-03-05 ヤマハ株式会社 Musical sound synthesization
JPH0799478B2 (en) * 1985-11-22 1995-10-25 カシオ計算機株式会社 Electronic musical instrument
GB8730216D0 (en) * 1987-12-29 1988-02-03 Lepetit Spa Process for preparation of pregnenooxazolines
CN101177443B (en) * 2006-11-09 2011-08-03 天津药业研究院有限公司 Novel steroid compound and uses thereof
CN110157764B (en) * 2019-05-29 2021-01-29 浙江仙琚制药股份有限公司 Preparation method of dexamethasone intermediate

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1070176B (en) * 1959-12-03 American Cyanamid Company, New York, N. Y. (V. St. A.) Process for the production of new steroid compounds of the 1, 4 - Pregnadiene series
US2837464A (en) * 1955-01-11 1958-06-03 Schering Corp Process for production of dienes by corynebacteria
DE1093792B (en) * 1957-11-27 1960-12-01 Pfizer & Co C Process for the production of 3-keto-í¸-steroids
US2981659A (en) * 1959-05-01 1961-04-25 Upjohn Co Method for the microbiological conversion of pregnane series steroids
DE1107225B (en) * 1959-08-05 1961-05-25 Hoechst Ag Process for the production of 1, 4, 17 (20) -Pregnatrienes
US3274182A (en) * 1963-12-28 1966-09-20 Searle & Co Process for reducing 19-methyl-1, 4-dien-3-ones to corresponding 19-nor-3-oxy-1, 3, 5(10)-trienes
NL6705450A (en) * 1965-10-22 1968-10-21
NL6703781A (en) * 1967-03-13 1968-09-16
US3718673A (en) * 1971-02-01 1973-02-27 Du Pont Process for the preparation of 21-chloro-6,6,9alpha-trifluoro-11beta, alpha, 17alpha-trihydroxy-1,4-pregnadien-3,20-dione 16,17-ketals and selected intermediates
US4101378A (en) * 1975-06-06 1978-07-18 Mitsubishi Chemical Industries Limited Process for the microbiological oxidation of steroids
US4246346A (en) * 1978-09-05 1981-01-20 Aktiebolaget Fermenta Antibiotic and steroid transformation process

Also Published As

Publication number Publication date
FI814127L (en) 1982-06-24
DK572081A (en) 1982-06-24
HU186454B (en) 1985-08-28
JPS57170197A (en) 1982-10-20
JPH0218071B2 (en) 1990-04-24
EP0055832B1 (en) 1986-02-26
RO83630A (en) 1984-06-21
DD202050A5 (en) 1983-08-24
DE3173923D1 (en) 1986-04-03
FI72144B (en) 1986-12-31
US4431732A (en) 1984-02-14
FI72144C (en) 1987-04-13
EP0055832A1 (en) 1982-07-14
DK157891B (en) 1990-02-26
ATE18257T1 (en) 1986-03-15
DK157891C (en) 1990-09-03

Similar Documents

Publication Publication Date Title
AU549773B2 (en) Culture tube rack
AU5364779A (en) Glass suitable for transforming into fibers
EP0167132A3 (en) Process for producing l-isoleucine by fermentation
GB2109406B (en) Process for culturing anaerobic bacteria and agents for preparing culture atmosphere
AU552506B2 (en) Method for metallizing carbon fibre reinforced plastic member
RO83630B (en) Process for preparing 11 beta, 21-dihydroxy-2'-methyl-5' beta-1, 4-pregnadieno (16,17-d)-oxazole-3,20-dione
YU291380A (en) Process for obtaining 6 alpha, 9 alpha-difluoro-16-methyl-predinisolone-17,21-esters
PT75496B (en) Process for preparing polysaccharide gums by microbial fermentation
ES479974A1 (en) Process for the preparation of 6-halo-pregnanes
DE3175049D1 (en) Process for the preparation of 3-oxo-delta-1,4-steroids
AU4081085A (en) Process for preparing glycosidic linkage related antigen
GB2035286B (en) Glass fibre reinforced cements and process for manufactureof same
ES8102591A1 (en) Micromonospora culture
GB2101131B (en) Method of producing guanosine by fermentation
HU178405B (en) Process for preparing ergocornine and beta-ergocryptine by fermentation
YU42432B (en) Process for obtaining buspyrone, 8-/4-/-/2-pyrimidinyl/-1-piperazinyl/buthyl/-8-azaspyro/4-,5/dekan-7,9-diones
GB2104914B (en) Process for manufacturing alcohol by fermentation
IL57788A (en) Microbiological process for preparing androst-4-ene 3,17-dione and novel laboratory mutants
EP0078061A3 (en) Method for culturing non-adhering mammalian cells
DE3273233D1 (en) Process for producing l-tryptophan by fermentation
GB2091761B (en) Process for the production of alcohol by fermentation
JPS53124680A (en) Tissue culturing apparatus equipped with centrifugau tube conveying system
BG32734A1 (en) Method for tobacco fermentation by application of sun energy
HUT36866A (en) Process for preparing cyclodopa by means of stereospecific microbiological reduction
JPS54129184A (en) Pretreatment of minute support against cell culture