RO72884B - Process for preparing indolic compounds - Google Patents

Process for preparing indolic compounds

Info

Publication number
RO72884B
RO72884B RO81868A RO8186875A RO72884B RO 72884 B RO72884 B RO 72884B RO 81868 A RO81868 A RO 81868A RO 8186875 A RO8186875 A RO 8186875A RO 72884 B RO72884 B RO 72884B
Authority
RO
Romania
Prior art keywords
preparing
indolic compounds
compounds
chloro
methyl
Prior art date
Application number
RO81868A
Other languages
Romanian (ro)
Other versions
RO72884A (en
Inventor
Plattner
Jarbert
Tretter
Welch
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US456641A external-priority patent/US3925409A/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of RO72884B publication Critical patent/RO72884B/en
Publication of RO72884A publication Critical patent/RO72884A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea de compusi indolici cu formula I din pag.1 a descrierii, în care X reprezinta clor, fluor, brom, metil, Z reprezinta fluor, clor, metoxi, R reprezinta o grupa în care A reprezinta -(CH2) indice m- în care m este 1 sau 2, Y reprezinta hidrogen, clor, fluor, metil, constînd în aceea ca se aduce în reactie un derivat indolic cu formula II în care Z, X si m au semnificatia aratata mai sus.The invention relates to a process for the preparation of the indole compounds of formula I of the description, wherein X represents chlorine, fluorine, bromine, methyl, Z represents fluoro, chloro, methoxy, R represents a group wherein A represents - (CH2) m - wherein m is 1 or 2, Y is hydrogen, chloro, fluoro, methyl, in that an indole derivative of the formula II in which Z, X and m are as defined above .

RO7581868A 1974-04-01 1975-04-01 PROCESS FOR THE PREPARATION OF INDOLIC COMPOUNDS RO72884A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45664074A 1974-04-01 1974-04-01
US456641A US3925409A (en) 1974-04-01 1974-04-01 4-Aryl-1,2,3,4-tetrahydropyrrolo{8 3,4-b{9 indoles

Publications (2)

Publication Number Publication Date
RO72884B true RO72884B (en) 1983-07-30
RO72884A RO72884A (en) 1983-08-03

Family

ID=27038317

Family Applications (1)

Application Number Title Priority Date Filing Date
RO7581868A RO72884A (en) 1974-04-01 1975-04-01 PROCESS FOR THE PREPARATION OF INDOLIC COMPOUNDS

Country Status (15)

Country Link
JP (1) JPS587635B2 (en)
AR (2) AR206812A1 (en)
AU (1) AU7955975A (en)
DD (1) DD118879A5 (en)
DE (1) DE2514084A1 (en)
DK (2) DK130575A (en)
ES (3) ES436157A1 (en)
FI (1) FI750940A7 (en)
FR (1) FR2265368A1 (en)
IL (1) IL46925A0 (en)
LU (1) LU72182A1 (en)
NL (1) NL7503700A (en)
NO (1) NO751055L (en)
RO (1) RO72884A (en)
SE (2) SE423630B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224329A (en) * 1979-01-23 1980-09-23 Pfizer Inc. 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
US4451655A (en) * 1982-05-17 1984-05-29 Pfizer Inc. Process for preparing carboline derivatives and compounds used in their preparation
ATE251622T1 (en) * 1998-12-21 2003-10-15 Janssen Pharmaceutica Nv BENZISOXAZOLES AND PHENONES AS ALPHA-2 ANTAGONISTS
RU2320662C1 (en) * 2006-08-24 2008-03-27 Андрей Александрович Иващенко SUBSTITUTED PYRROLO[4,3-b]INDOLES, COMBINATORY AND FOCUSED LIBRARY, PHARMACEUTICAL COMPOSITION, METHODS FOR THEIR PREPARING AND USING
EP2560676B8 (en) * 2010-04-22 2016-10-12 Intra-Cellular Therapies, Inc. Organic compounds

Also Published As

Publication number Publication date
DE2514084A1 (en) 1975-11-20
DK130575A (en) 1975-10-02
ES436157A1 (en) 1977-04-16
AR206812A1 (en) 1976-08-23
SE423630B (en) 1982-05-17
LU72182A1 (en) 1976-03-02
AR207799A1 (en) 1976-10-29
SE8200047L (en) 1982-01-07
JPS587635B2 (en) 1983-02-10
DD118879A5 (en) 1976-03-20
ES453787A1 (en) 1978-01-01
IL46925A0 (en) 1975-05-22
ES453788A1 (en) 1978-01-01
FR2265368B1 (en) 1978-07-28
NL7503700A (en) 1975-10-03
FI750940A7 (en) 1975-10-02
NO751055L (en) 1975-10-02
SE7502927L (en) 1975-10-02
AU7955975A (en) 1976-09-30
JPS50140494A (en) 1975-11-11
DK187878A (en) 1978-05-01
FR2265368A1 (en) 1975-10-24
RO72884A (en) 1983-08-03

Similar Documents

Publication Publication Date Title
RO86698B (en) Process for preparing (1-piperidinylalkyl)-pyrimidinone
RO81944B (en) Process for the preparation of imidosulphamides
BG33006A3 (en) Method for obtaining of n- (perfluoracil)- n- phosphonomethyl- glycine compounds
RO93218B (en) Process for preparing 2-oxindole derivatives
RO72884B (en) Process for preparing indolic compounds
BG35330A3 (en) METHOD FOR OBTAINING 3-IODOMETHYLCEPHALOSPORINS
RO72547B (en) PROCESS FOR THE PREPARATION OF 2 ', 3, 6'-TRICYL-4-CYAN-4'-BENZOYLURIDIDIFENYL ESTERS
BG31649A3 (en) METHOD FOR OBTAINING NITRO COMPOUNDS
BG35597A3 (en) METHOD FOR OBTAINING OXOBENZOTHIAZINOA DIOXIDE CARBOXAMIDES
BG32855A3 (en) METHOD FOR OBTAINING 1-OXADETHIACEPHALOSPORINS
RO86674B (en) PROCEDURE FOR THE PREPARATION OF BENZAMIDE DERIVATIVES
RO92200B (en) PROCEDURE FOR PREPARING S-BENZYL CARBAMATE
RO81117B (en) Process for preparing thiazolidenoxopropionitryl salts
RO101429B (en) ERBICIDA SOLIDA COMPOSITION
RO66265B (en) Process for preparing s-triazole-(3,4-b)-benzotmetathiazoles
BG33289A3 (en) Method for obtaining of 8, 8- disubstituated- 6- methylergolin
BG34334A3 (en) Method for obtaining phosphonic acid derivates
RO71183B (en) Process for preparing substituited 20-on-steroids
FR2369260A1 (en) 2-1,5-DISUBSTITUTED 2-PYRROLIDONS AND THEIR PREPARATION METHODS
BG35045A3 (en) METHOD FOR OBTAINING SUBSTITUTED TRIARYLTHIAZOLE COMPOUNDS
FI852951L (en) CHEMICAL SYNTHESES.
BG31072A4 (en) Method for obtaining of sulphinylazetidinon
BG28045A4 (en) METHOD FOR OBTAINING OCTADIENNITRILE DERIVATIVES
FR2255895A1 (en) Substd. benzo(b,d)pyrans - as anxiolytic, antidepressive and antipsychotic agents
ES441289A1 (en) 6-aryloxy-2-oxo-1-aza-4-oxa (or thia)-spiro(4,5)+0 decanes