RO72884B - Process for preparing indolic compounds - Google Patents

Process for preparing indolic compounds

Info

Publication number
RO72884B
RO72884B RO81868A RO8186875A RO72884B RO 72884 B RO72884 B RO 72884B RO 81868 A RO81868 A RO 81868A RO 8186875 A RO8186875 A RO 8186875A RO 72884 B RO72884 B RO 72884B
Authority
RO
Romania
Prior art keywords
preparing
indolic compounds
compounds
chloro
methyl
Prior art date
Application number
RO81868A
Other languages
Romanian (ro)
Other versions
RO72884A (en
Inventor
Plattner
Jarbert
Tretter
Welch
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US456641A external-priority patent/US3925409A/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of RO72884B publication Critical patent/RO72884B/en
Publication of RO72884A publication Critical patent/RO72884A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea de compusi indolici cu formula I din pag.1 a descrierii, în care X reprezinta clor, fluor, brom, metil, Z reprezinta fluor, clor, metoxi, R reprezinta o grupa în care A reprezinta -(CH2) indice m- în care m este 1 sau 2, Y reprezinta hidrogen, clor, fluor, metil, constînd în aceea ca se aduce în reactie un derivat indolic cu formula II în care Z, X si m au semnificatia aratata mai sus.The invention relates to a process for the preparation of the indole compounds of formula I of the description, wherein X represents chlorine, fluorine, bromine, methyl, Z represents fluoro, chloro, methoxy, R represents a group wherein A represents - (CH2) m - wherein m is 1 or 2, Y is hydrogen, chloro, fluoro, methyl, in that an indole derivative of the formula II in which Z, X and m are as defined above .

RO7581868A 1974-04-01 1975-04-01 PROCESS FOR THE PREPARATION OF INDOLIC COMPOUNDS RO72884A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45664074A 1974-04-01 1974-04-01
US456641A US3925409A (en) 1974-04-01 1974-04-01 4-Aryl-1,2,3,4-tetrahydropyrrolo{8 3,4-b{9 indoles

Publications (2)

Publication Number Publication Date
RO72884B true RO72884B (en) 1983-07-30
RO72884A RO72884A (en) 1983-08-03

Family

ID=27038317

Family Applications (1)

Application Number Title Priority Date Filing Date
RO7581868A RO72884A (en) 1974-04-01 1975-04-01 PROCESS FOR THE PREPARATION OF INDOLIC COMPOUNDS

Country Status (15)

Country Link
JP (1) JPS587635B2 (en)
AR (2) AR207799A1 (en)
AU (1) AU7955975A (en)
DD (1) DD118879A5 (en)
DE (1) DE2514084A1 (en)
DK (2) DK130575A (en)
ES (3) ES436157A1 (en)
FI (1) FI750940A7 (en)
FR (1) FR2265368A1 (en)
IL (1) IL46925A0 (en)
LU (1) LU72182A1 (en)
NL (1) NL7503700A (en)
NO (1) NO751055L (en)
RO (1) RO72884A (en)
SE (2) SE423630B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224329A (en) * 1979-01-23 1980-09-23 Pfizer Inc. 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
US4451655A (en) * 1982-05-17 1984-05-29 Pfizer Inc. Process for preparing carboline derivatives and compounds used in their preparation
CZ294532B6 (en) * 1998-12-21 2005-01-12 Janssen Pharmaceutica N. V. Benzoisoxazoles and phenones as alpha2-antagonists, process of their preparation, use and pharmaceutical composition in which they are comprised
RU2320662C1 (en) * 2006-08-24 2008-03-27 Андрей Александрович Иващенко SUBSTITUTED PYRROLO[4,3-b]INDOLES, COMBINATORY AND FOCUSED LIBRARY, PHARMACEUTICAL COMPOSITION, METHODS FOR THEIR PREPARING AND USING
RU2591194C2 (en) * 2010-04-22 2016-07-10 Интра-Селлулар Терапиз, Инк. Organic compounds

Also Published As

Publication number Publication date
FR2265368B1 (en) 1978-07-28
AR206812A1 (en) 1976-08-23
SE7502927L (en) 1975-10-02
NL7503700A (en) 1975-10-03
AR207799A1 (en) 1976-10-29
SE423630B (en) 1982-05-17
SE8200047L (en) 1982-01-07
ES436157A1 (en) 1977-04-16
DK187878A (en) 1978-05-01
DD118879A5 (en) 1976-03-20
JPS587635B2 (en) 1983-02-10
ES453788A1 (en) 1978-01-01
LU72182A1 (en) 1976-03-02
FI750940A7 (en) 1975-10-02
ES453787A1 (en) 1978-01-01
AU7955975A (en) 1976-09-30
DK130575A (en) 1975-10-02
RO72884A (en) 1983-08-03
JPS50140494A (en) 1975-11-11
NO751055L (en) 1975-10-02
DE2514084A1 (en) 1975-11-20
IL46925A0 (en) 1975-05-22
FR2265368A1 (en) 1975-10-24

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