RO64266B1 - Rifamicine hidrosolubile si procedeu de preparaea a acestora - Google Patents

Rifamicine hidrosolubile si procedeu de preparaea a acestora

Info

Publication number
RO64266B1
RO64266B1 RO86586A RO8658676A RO64266B1 RO 64266 B1 RO64266 B1 RO 64266B1 RO 86586 A RO86586 A RO 86586A RO 8658676 A RO8658676 A RO 8658676A RO 64266 B1 RO64266 B1 RO 64266B1
Authority
RO
Romania
Prior art keywords
soluble
acid
hydrosoluble
preparing
rifamicin
Prior art date
Application number
RO86586A
Other languages
English (en)
Other versions
RO64266A2 (ro
Inventor
Nitelea Ion
Sauciuc Alexandru
Paunescu Eugeniu
Albu Margareta
Diaconu Constantin
Original Assignee
Institutul De Cercetari Chimico-Farmaceutice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institutul De Cercetari Chimico-Farmaceutice filed Critical Institutul De Cercetari Chimico-Farmaceutice
Priority to RO86586A priority Critical patent/RO64266B1/ro
Priority to DE19772728868 priority patent/DE2728868A1/de
Publication of RO64266A2 publication Critical patent/RO64266A2/ro
Publication of RO64266B1 publication Critical patent/RO64266B1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Rifamicine hidrosolubile caracteriyate prin aceea ca au structura chimica din formula generala I: R .An (I) în care R reprezinta molecula derivatului de rifamicina ales dintre hidrazone, alchilhidrazone si oxime ale 3-formilrifamicinei SV, A reprezinta molecula sarii alcaline a unui acid organic care poate fi un acid organic care poate fi un acid alifatic cu o catena de 1 pîna la 16 atomi de carbon normala sau ramificata sau un acid aromatic nesubstituit sau substituit în nucleu, sau un acid cu structura steroidica, iar n reprezinta numarul de molecule de sare si poate fi cuprins între 0,5 si 5 si sunt substante amorfe sau microcristaline, de culoare portocalie pîna la rosu închis brun, foarte solubile în hidrocarburi halogenate, solubile în apa si alcoli alifatici inferiori greu solubile în hidrocarburi alifatice.Procedeu de preparare a rifamicinelor a rifamicinelor hidrosolubile, conform revendicarii 1, caracterizat prin aceea case aduce în contact derivat de rifamicina R ........
RO86586A 1976-06-25 1976-06-25 Rifamicine hidrosolubile si procedeu de preparaea a acestora RO64266B1 (ro)

Priority Applications (2)

Application Number Priority Date Filing Date Title
RO86586A RO64266B1 (ro) 1976-06-25 1976-06-25 Rifamicine hidrosolubile si procedeu de preparaea a acestora
DE19772728868 DE2728868A1 (de) 1976-06-25 1977-06-27 Wasserloesliche rifamycinen und verfahren zu deren herstellung

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RO86586A RO64266B1 (ro) 1976-06-25 1976-06-25 Rifamicine hidrosolubile si procedeu de preparaea a acestora

Publications (2)

Publication Number Publication Date
RO64266A2 RO64266A2 (ro) 1983-04-29
RO64266B1 true RO64266B1 (ro) 1983-04-30

Family

ID=20096414

Family Applications (1)

Application Number Title Priority Date Filing Date
RO86586A RO64266B1 (ro) 1976-06-25 1976-06-25 Rifamicine hidrosolubile si procedeu de preparaea a acestora

Country Status (2)

Country Link
DE (1) DE2728868A1 (ro)
RO (1) RO64266B1 (ro)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795568C3 (de) * 1964-07-31 1974-07-18 Gruppo Lepetit S.P.A., Mailand (Italien) 3-Hydroxymethyl-rifamycin SV und Verfahren zu seiner Herstellung. Ausscheidung aus: 1595883
GB1159267A (en) * 1966-11-03 1969-07-23 Lepetit Spa Rifamycin Derivatives
DE1966304C3 (de) * 1969-08-01 1975-06-19 Gruppo Lepetit S.P.A., Mailand (Italien) 4-Desoxyrlfamycin-SV -derivate
SE458505B (sv) * 1979-07-10 1989-04-10 Lepetit Spa Anvaendningen av rifamycin sv och salter daerav foer framstaellning av en beredning foer behandling av reumatoid artrit samt vissa av salterna och deras framstaellning

Also Published As

Publication number Publication date
RO64266A2 (ro) 1983-04-29
DE2728868A1 (de) 1978-05-11

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