RO127809B1 - Phytotherapeutical product for nervous relaxation - Google Patents

Abstract

The invention relates to an antistress product. According to the invention, the product comprises 8...12 parts of gentian (Gentiana lutea), 7...12 parts of black grapes seeds (Vitis vinifera), 8...12 parts of plum tree leaves (Prunus domestica) and basil (Ocimum basilicum), respectively, 7...12 parts of grapefruit seeds (Citrus decumana), 5...10 parts of olive tree leaves (Olea europea), 10...14 parts of lavender (Lavendula angustifolia), 9...14 parts of burdock (Arctium lappa), 8...12 parts of bilberry bush leaves (Vaccinum myrtillus), 7...12 parts of linseeds (Linum usitatissimum) and raspberry bush leaves (Rubus idaeus), 1...3 parts of vitamin C (ascorbic acid), 7...12 parts of Ginko Biloba, 5...10 parts of Ginseng, 1...3 parts of hemp seeds (cannabis sativa), 1...3 parts of marigold (Calendula officinalis), the parts being expressed by weight.

Description

The invention relates to a phytotherapeutic product for nerve relaxation, psychhorelaxant, remineralizing agent and antistress, for use in the phytopharmaceutical field.

The specialized literature of the treatments of the disorders of the nervous system, carried out with the help of medicinal plants, mentions some preparations such as:

RO 122 436 B1 refers to a phytotherapeutic composition, having sedative, miorelaxative, antispastic action, consisting of 40 parts Lavandula flos, 30 parts Melissae folium and 30 parts Millefollii flos, in powder form, containing 13.36 ... 16.71% mineral substances and 0.64 ... 0.72% aglics expressed in ursolic acid, the parts being expressed by weight, and in the process of obtaining it.

RO 115120 B1 describes an anti-stress tea, consisting of 28 ... 32 parts Herba Lions,

20 .. .22 parts Flores and Folium Crataegi, 10 ... 12 parts Flores Lavandulae, 10 ... 12 parts Flores Tiliae, 10 ... 12 parts Herba Origani and 18 ... 22 parts Herba Viola tricolor, the parts being expressed by weight.

RO 105651 B1 has a medicinal composition with antidiabetic action, consisting of 20 ... 25 parts powder obtained from the whole plant Phaseolus vulgaris, 20 ... 25 parts leaves powder of Vaccinum myrtillus, 20 ... 25 parts leaves powder Morus species, 1,5 ... 2 parts Apilarnil, 10 ... 15 parts pollen or pollen paste without exine, optional

1 .. .3 parts vitamin B complex, composed of quantities equal to Β _υ B ₂ and B ₆ , 3 ... 5 parts magnesium stearate and excipients for compression up to 100 parts, the parts being expressed by weight.

RO 122015 B1 refers to a nutritional supplement, vegetable, with antioxidant effect, intended to prevent the formation of free radicals in the body and the appearance of degenerative diseases, consisting of 50 to 100 parts dried extract of Myrtilli fructus, 50 .75 parts grape seed extract, 100 parts Amaranthus caudatus herba, 50 parts Hippophae fructus pulp, 100 parts Spirulina platensis powder and 100 parts sodium ascorbate, parts expressed by weight on the tablet, together with pharmaceutically acceptable excipients. .

In general, for the treatment of central nervous system disorders, the most commonly used medicinal products are those of chemical synthesis. Of these, it is mentioned:

R0119224 B1 for the treatment of psychotic disorders, comprising a composition containing a pharmaceutically acceptable carrier and biodegradable and biocompatible microparticles containing 1 ... 90% 1,2-benzazole of the formula: 1,2-benzizoxazoles and 1,2-benzizothiazoles , 3-piperidinyl substituted.

The aforementioned product has the following disadvantages: the mentioned compounds are potential small antagonists of serotonin and dopamine, being considered useful as antipsychotics. This composition is difficult to apply, as it is applied under strict control, only by specialized personnel, at fixed hours, it acts only at the level of the psychic, not the nervous system, which only helps in a temporary soothing, so it acts on the effect, not and the cause.

The technical, objective problem, which the invention seeks to solve, is to obtain a good nervous relaxation.

The technical solution to this problem consists in the fact that a mixture of medicinal plants is associated in a phytotherapeutic composition in powder form.

The phytotherapeutic product, according to the invention, consists of: 8 ... 12 parts Gentiana Iutea, 7 ... 12 parts Semen Vitis vinifera, 8 ... 12 parts Folium Prunus domestica, 8 ... 12 parts Ocimum basilicum, 7. .. 12 parts Semen Citrus decumana, 5 ... 10 parts Folium Olea Europea,

10 .. .14 parts Lavandula angustifolia, 9 ... 14 parts Arclium lappa, 8 ... 12 parts Folium Vaccinium myrtillus, 7 ... 12 parts Linum usitatissimum, 7 ... 12 parts We use Rubus idaeus, 1.. .3 parts Ascorbic acid, 7 ... 12 parts Ginkgo Biloba, 5 ... 10 parts Ginseng, 1 ... 3 parts Semen Cannabis sativa and 1 ... 3 parts Calendula officinalis, parts being expressed by weight.

RO 127809 Β1

The phytotherapeutic product according to the invention has the following advantages: 1

- helps the body to return to normal function and eliminate any type of psychosis;

- it is at the same time a good soothing, sedative, antistress, remineralizer, detoxifier 3 and neuroglandular activator;

- it can be applied at any time of day, without any particular rigor by anyone, 5

- does not create dependency;

- restores glandular functions, acting on the pituitary-thyroid-thymus-pancreas axis, thus 7 rebalancing the central nervous system.

The following is a concrete example of embodiment of the invention.9

Example. Weigh the following plant components, as follows: 8 g black grape seeds, 8 g gentian, 8 g plums, 8 g basil, 7 g grapefruit seeds, 11 g lavender, 9 g crusts, 8 g blueberries, 7 g in , 7 g raspberries, 7 g ginkgo biloba, 5 g olive seeds, 5 g ginseng, 1 g vitamin c, 1 g hemp seeds and 1 g yellowberries.13

The above plants are allowed to dry under controlled conditions, then, in a stainless steel basin, they are ground to a size of 0,10 ... 0,20 mm and mixed in 15 proposed quantities. After mixing, the powder is packaged in capsules or bottles with a threaded cap.17

The control of raw materials respects the quality standards of the European Pharmacopoeia.

The dose administered, estimated to be with maximum efficiency, according to preliminary tests 19, was 3 ... 9 capsules per day, after the main meals.

The administration of the powdered product was done before meals with 10 ... 15 min, 21 the product being very easy to bear. Over 9 capsules / day, the product does not have a greater effect, but does not cause nervous or mental disorders. 2. 3

The powder can be administered as such and in the form of tablets or capsules.

The invention is further described in detail. 25

The active substances in the composition of the product according to the invention act on the nervous system and endocrine glands of the body, and implicitly on the psychic, with 27 remarkable results in restoring the general state of both nervous and mental relaxation.

The effect is synergistic for the treatment of manifestations related to nervous or mental imbalances.

The composition of the claimed product is based on active, natural substances, existing 31 in the plants of the formula, such as: levulose, glucose, tartaric acid, malic acid, tannin, volatile oil, fiber, calcium, iron, phosphorus, magnesium, sodium, protein, carbohydrates, saturated and unsaturated fats, 33 rates, potassium, manganese, iron oxide, chlorine, silicon, iodine, arsenic, phosphoric acid, pectins, lycopene, vitamins A, B, E and C, gentiopicrina, amarogentin, holosides, gentianine, gentisima, hetero- 35 bitter walls, cellulose, nitrogenous and fatty matrices, pantothenic acid, inulin and potassium salts.

The main therapeutic and pharmacodynamic effects are the following: psychhorelaxant. 37 Energizing, remineralizing, detoxifying, anti-infective, activates the thyroid, maintains capillary resistance, liver decongestant, antithermal, antiparasitic, comforting soothing in 39 moments of sadness, antimicrobial, neuroglandular activator, sedative, helps meditation, antistress. invigorating, anti-bronchitis, antidiabetic, antiastenic, antifungal, antioxidant, 41 hypocholesterolemia, heart disease, LDL oxidation, atherosclerosis, lowering of systolic blood pressure, worry and emotional cold. 43

Raw materials are easy to buy and process, the action of the product is fast, easy to bear; it assimilates quickly and easily, without side effects, the qualities of the 45 plants are enhanced so that the result is fast and with maximum efficiency; has sedative action on the central nervous system, but invigorating, does not influence the state of awakening. 47

RO 127809 Β1

By the gentle but complex action characteristic of the plant extracts, the product according to the invention is recommended for breaks of long-term treatments with synthetic drugs, for disorders of the nervous system and in long-lasting strains.

The claimed product allows association with allopathic medication, which enhances its effect; at the same time, it is an alternative to the synthetic products; The quantities of extracts used ensure concentrations in active principles sufficient to achieve the therapeutic effect and at the same time prevent the undesirable effects due to overdose.

It is known that seeds of domestic hemp (Cannabis sativa) contain substances such as: essential fatty acids, omega 3, 6 and 9, proteins that contain all the essential amino acids, fiber, calcium, iron, phosphorus, magnesium, sodium, vitamin E, sugars, proteins, carbohydrates, saturated and unsaturated fats.

In Cannabis sativa they appear, as in the other types of cannabis and psychoactive substances, but in a much lower concentration, up to 50 times less, as: THC (A9-tetrahydrocannabinol), a psychoactive molecule that produces the sensations of relaxation. and plant-synthesized cannabinoid, tetrahydrocannabinol, cannabinol, cannabidiol, cannabinolidic acid, cannabigerol and cannabichromene, Delta-9-tetrahydrocannabinol. The effects are relaxing, but also remineralizing.

It is known that ascorbic acid (vitamin C) is: anti-infectious, invigorating, detoxifying, activates the thyroid and maintains capillary resistance.

Ginkgo Biloba is known to be used to treat circulatory disorders and to increase memory. The extract can be used for diseases associated with decreased blood flow in the brain, especially in the elderly, it also improves blood circulation by dilating blood vessels, reducing platelet adhesion, reducing the risk of clots, which are a factor Activation in some skin diseases, such as psoriasis. The leaves contain two types of flavonoid and terpenoid substances, which appear to have antioxidant properties, more precisely, can neutralize free radicals, which are harmful compounds to the body and cell membrane, altering the DNA and contributing to the body's aging. The plant has a positive effect on brain functioning, aids mental alertness, improves memory, reduces energy and mental fatigue, helps control inflammation and asthma, increases metabolism efficiency, regulates neurotransmitters and stimulates oxygen levels in the brain; helps control cholesterol which is usually related to hardening of the arteries and helps to relax the contracted vessels; supports the treatment of impotence and infertility in men; acts on ear disorders and eye disorders and on the circulatory system.

It is also known that the root of life (Ginseng): it strengthens the immune system, stimulates sexual activity, normalizes blood pressure and blood sugar, lowers cholesterol and protects the liver; it is effective in overwork, stress, chronic fatigue, neurasthenia, depression, convalescence, increases the ability to concentrate, increases immunity, preserves the integrity of blood vessels and normal functioning of the heart, is gastric tonic, lymphatic stimulant, against dizziness, general tonic and stimulant of cognitive functions, accelerates and normalizes metabolism, regenerates intestinal villi, detoxifies the body, stimulates cellular regeneration and promotes food absorption.

The chemically active compounds contain a complex mixture of triterpene saponozides, known as ginsenosides. The most important were coded Rb1, Rb2, Rb3, Rc and Rd, protopanaxadiol derivatives, and Re, Rf, Rg1, Rg2 and Rh1 derivatives, protopanaxatriol derivatives. To date, 30 ginsenosides have been identified and characterized.

RO 127809 Β1

It is known that grapefruit seeds are: antimicrobials, antifungals, antioxidants and 1 hypocholesterolemic agents. They are rich in: pectins, calcium, vitamin C, lycopene and fiber, give the sensation of satiety, help reduce the blood value of cholesterol, stimulate 3 metabolic processes of burning of fatty tissues and their transformation into energy needed by the body, increase resistance to bacteria (Helicobacterpilorî) and fungi. 5

PRECLINICAL TESTS

Comparison of the proposed claimed product with respect to products A, B, C and D 7

The radiesthetic measurements showed the following values for the above mentioned products: the claimed product has 19 100 u. e., product A has 12 000 µm. e. Bare product 9 13 900 u. e. product C has 11 100 u. e., and product D has 11 000 u. e. (u. e. = energy units). 11

This test was corroborated with the test regarding the Kirilian effect, in which the products were also tested, obtaining the following results: the length of the 13 layers measured for the claimed product was 3.4 ... 3.6 mm, for product A, de

1.8 ... 2.1 mm, for product B, 2.5 ... 2.8 mm, for product C, 1.6 ... 1.8 mm, and 15 for product D, for 1.5 ... 1.6 mm.

The conclusion is that the claimed product has an energy capacity of 21 ... 44% higher than products B and D, and compared to products B and C, an energy capacity of 73 ... 100% is observed; In conjunction with the previous test, it is clearly observed that the therapeutic effect 19 of the claimed product, compared to the presented products, is synergistic and complex, with a strong effect on the central nervous system. 21

CLINICAL TESTS

An evaluation of the therapeutic efficacy of the product according to the invention was performed, as an adjuvant in the treatment of various nervous disorders, associated with diseases.

METHOD 25 Between January 2010 - January 2011, a number of 20 patients, ranging in age from 27 10 to 60 years, were clinically monitored and monitored at the phytotherapeutic consulting firm. Patients presented to the ward with various types of average nervous disorders; they were presented at the office with the complete medical documentation (para-clinical investigations), as well as with the allopathic therapeutic schemes up to that date.

All patients requested and accepted the completion of the allopathic treatment with phytotherapeutic treatment, corresponding to their condition. Following the presentation of patients to the practice and following the corroboration of the anamnestic, clinical and paraclinical data, the adjuvant treatment with 33 this product was instituted.

following the administration of the individual treatment schemes (the conditions 35 presented by each patient were taken into account), which involved the accompanying product with other dietary supplements, recommended for the respective acute, associated diseases; a large 37 part of the patients updated their clinical and paraclinical investigations, so that the clinical observations and the laboratory data found before and after the 39 adjuvant treatment could be compared with the claimed product.

The monitoring period was 90 days, patients presenting to the control every 41 days.

TRATAMENT43

In all patients, the composition was applied 2 ... 3 times a day, in the form of a mixture of the powdered product with honey bees, for a period of one month. At the end of the 45 administration period, there was an improvement, until the effects on the central nervous system disappeared.47

RO 127809 Β1

The product was well tolerated. The results, after one month of treatment, were favorable. No adverse reactions were reported.

CONCLUSIONS

The results obtained in this group of patients prove that the use of the product for the treatment of various average psychoses has many benefits. The properties of the product are due to the active principles of the composition, having antiseptic, decongestant, soothing and nutritional effects. These observations can be considered as relevant, for the inclusion of the product as an adjuvant treatment, for a wide range of disorders in the psychological sphere.

Treatment for the improvement of schizophrenia

5 people with schizophrenic syndrome, agitated people and self-destructive tendencies were tested. By paraclinical investigations, a decrease of central nervous system function was found. By applying the treatment with the claimed product, 3 times a day, two capsules, for a minimum of 3 months to 6 months, a gradual elimination of the nervous stresses, elimination of the destructive tendencies, calming of the patients, thus reducing the half, of the allopathic treatment, for the same period of time.

CONCLUSIONS

The results obtained in this group of patients prove that the use of the product for the elimination of nervous stresses, the claimed product having effect on the pituitary-thyroid-thymus-pancreas glands, with the aforementioned effects, has many benefits. The properties of the product are due to the active principles of the composition, which act synergistically, having calming effects. These observations can be considered as relevant, for the inclusion of the product as an adjuvant treatment, for a wide range of disorders in the psychological sphere.

The body's response to treatment was favorable. No adverse reactions were reported.

Claims (1)

Phytotherapeutic product for nerve relaxation, psycho-relaxant, remineralizing agent and 3 antistress, characterized in that it consists of: 8 ... 12 parts Gentiana Iuțea, 7 ... 12 parts Semen Vitis vinifera, 8 ... 12 parts Folium Prunus domestica, 8 ... 12 parts Ocimum 5 basilicum, 7 ... 12 parts Semen Citrus decumana, 5 ... 10 parts Folium Olea Europea, 10 ... 14 parts Lavandula angustifolia, 9 ... 14 parts Arclium lappa, 8. .. 12 parts Folium Vaccinium 7 myrtillus, 7 ... 12 parts Linum usitatissimum, 7 ... 12 parts We use Rubus idaeus, 1 ... 3 parts Ascorbic acid, 7 ... 12 parts Ginkgo Biloba, 5 ... 10 parts Ginseng, 1 ... 3 parts Semen Cannabis sativa 9 and 1 ... 3 parts Calendula officinalis, the parts being expressed by weight.