RO127077B1 - Antiseborrheic product - Google Patents

Abstract

The invention relates to an antiseborrheic product. According to the invention, the product consists of 8...11 parts of laurel leaves, 5...8 parts of hemp seeds, 8...13 parts of Aloe vera, 5...10 parts of propolis, 8...13 parts of plantain, 9...13 parts of celandine, 9...13 parts of juniper, 8...12 parts of Our Lady's bedstraw, 8...11 parts of walnut, 8...12 parts of grapefruit seeds and 8...11 parts of dandelion, the parts being expressed by weight.

Description

The invention relates to a powdery, anti-sebum product, having an effect on the sebaceous glands, but also on the pituitary and thymus glands, used in the phytopharmaceutical industry.

The specialized literature cites a number of herbal products with antisheba effect:

RO 109811 B1 refers to a nutritional and anti-sebum solution, consisting of: resorcine, salicylic acid, hormonal derivative (methyltestosterone or dihydrofoliculin), hydroalcoholic extract of Urtica droica, preservative, perfume compositions and distilled water;

RO 115937 B1 describes a cosmetic, anti-sebum mask consisting of: collagen, vitamin B6, D-panthenol, redoxin, salicylic acid, allantoin, nipagin, nipasol, N-acetylthiazolidinecarboxylic acid.

The above-mentioned products have the following disadvantages: it is applied externally, which does not eliminate the cause of the production of excess sebum or sebum, so it does not eliminate the cause.

RO 126833 A2 refers to a phytotherapeutic product for weight loss, consisting of: 8 ... 10 parts Aloe vera, 7 ... 9 parts grapefruit seed extract, 7 ... 9 parts mulberry, 7 ... 9 parts lavender, 7 ... 9 parts yellow, 7 ... 9 parts red beet extract, 3 ... 6 parts carrot extract, 4 ... 6 parts cabbage extract, 5 ... 7 parts pelin, 3 ... 6 parts gentian, 2 ... 6 parts parsley extract, 3 ... 6 parts olive oil extract, 2 ... 6 parts raspberries, 1 ... 3 parts bay, 0.5. ..2 parts of lemon grains, if present in powder form, and additionally containing, if present in liquid form, 0.5 ... 1 part citric acid, 0.050 ... 1 part benzoate of sodium, 20 ... 22 parts ethyl alcohol of 5 ° or grapefruit juice, the solid parts being expressed by weight, and the liquid parts, by volume;

RO 125953 B1 mentions a phytotherapeutic product in powder form, intended for detoxifying the body, consisting of: 10 ... 15 parts Hippophae rhamnoides, 10 ... 15 parts Ocimum basilicum, 10 ... 15 parts Hypericum perforatum, 5 ... 10 parts Salvia officinalis,

5 .. .15 parts Viscum album, 10 ... 15 parts Juniperus communis, 10 ... 15 parts Althea officinalis,

5 .. .10 parts Chelidonium majus, 10 ... 15 parts Epilobium montanum, 5 ... 10 parts Allium sativum,

5 .. .10 parts Mentha piperita, parts being expressed by weight;

RO 117999 B presents an instant balneotherapeutic composition, with antirheumatic action, consisting of: 1.5 ... 1.65 parts Aetheroleum pini montanae and

98.5 .. .108.35 parts dry extract, standardized in minimum 4% total polyphenols, expressed in cinarine, obtained by processing the following mixture of medicinal plants: 2.8 ... 8.4 parts Matricaria recutita, 5 ... 15 parts Fraxinus excelsior, 5 ... 15 parts Betula verucosa, 8 ... 24 parts Salix alba, 4.4 ... 13.2 parts Symphytum officinale, 2.75 ... 8.25 parts Phaseolus vulgaris,

5.5 .. .16.5 parts Gallium verum, 2.75 ... 8.25 parts Thymusserpillum, 2.75 ... 8.25 parts Equisetum arvense, 5.5 ... 16.5 parts Acorus calamus, 5. .15 parts Juglans direct, which is subjected to water extraction, concentration under reduced pressure and drying by atomization, the parts being expressed by weight;

Virgil T. Geiculescu, in Biotherapy, pp. 262-265, Scientific and Encyclopedic Publishing House, Bucharest, 1987, describes propolis as "a precious apicultural product, with strong bactericidal and bacteriostatic effects". The action of propolis is largely due to its chemical composition. “Its anesthetic effects are exceptional: 3.5 times greater than cocaine and 5.2 times greater than novocaine. It is a remarkable therapeutic preparation with bactericidal, antimycotic, antitoxic, antiviral, anti-inflammatory, analgesic and regenerative action ... Propolis has no side effects. It can generally be used where medicines made from herbs or synthetic materials do not work. Long-term use of propolis emulsion in water or alcohol does not lead to dysbacteriosis, which is of great practical importance ”;

RO 127077 Β1

S. Mocanu, D. Răducanu, in Medicinal Plants, Vegetables, Fruits and Cereals in 1 Therapeutics, pp. 116-118, Military Publishing House, Bucharest, 1989, refers to Pătlagina (Plantago lanceolata), and to its pharmacological action. , it is mentioned that “due to 3 tannins and aucubozide it has astringent and antipruritic properties. It fluids bronchial secretions and helps eliminate them. Due to aucubozide, it is bactericidal. Due to allantoin, 5 is healing ”;

In www.medicalnewstoday.com, titled "Allergic skin could be treated with a 7 substance found in Cannabis, published by Tănase Alexandra, August 31, 2007, presents a study on" the administration of a substance found in Cannabis, which 9 could help the body's natural protective system to alleviate allergic skin disease (allergic dermatitis) .... In previous studies, two natural cannabinoid compounds (similar to Cannabinus 11) were isolated - one from the brain, called anandamide ( from the word ananda which signifies supreme joy in Sanskrit) and another from the intestines, called 2-AG. These two cannabinoids, 13 together with their receptors and different enzymes involved in the synthesis and degradation of cannabinoids, comprise the endocannabinoid system. These materials have similar effects to those of the active compounds in hashish and marijuana, cannabis products ... the results clearly show a projective role of the endocannabinoid system in relation to the skin allergy and suggest that 17 the development of cannabinoid compounds based on the elements produced from the cannabis plant could improve therapeutic treatment for humans. ” 19

The technical problem proposed to be solved by the present invention is the stimulation of cellular functions, with effect on the sebaceous glands, for their regulation and elimination of excess sebum, as well as on the pituitary gland and the thymus.

The solution consists in associating, in a powdered form, the following 23 plants: Dafin leaves, Hemp seeds, Aloe vera, Propolis, Pâtlagina, Rostopască, Juniper, Sânziene, Walnut and Grapfrut seeds. 25

The powdered product according to the invention consists of: 8 ... 11 parts leaves of Laurus nobilis, 5 ... 8 parts seeds of Cannabis sativa, 8 ... 13 parts Aloe vera, 5 ... 10 parts propolis, 27 8 ... 13 parts Plantago lanceolata, 9 ... 13 parts Chelidonium majus, 9 ... 13 parts Juniperus communis, 8 ... 12 parts Galium verum, 8 ... 11 parts Juglans Regia, 8 ... 12 29 pips parts of Citrus decumana, parts are expressed by weight.

The powdered product according to the invention has the following advantages: 31

- is a product that is ingested, so it acts through internal administration, to stimulate the sebaceous glands, helping the body to return to normal function and eliminate 33 seborrhea;

- it acts on regulating the function of the thymus and pituitary gland;

- it is at the same time a very good anti-inflammatory, cellular regenerator and nerve soothing; 37

- it can be administered at any time of the day, without any particular rigor;

- has no adverse reactions, is easily administered, acting as a good protector 39 anti-hepatitis, anti-anemic, anti-infectious and anti-tumor.

The following is a concrete example of embodiment of the invention.41

Example of realization. The following plant components are controlled dry: 10 g bay leaf, 8 g hemp seed, 10 g Aloe vera, 5 g propolis, 10 g seagrass, 10 g 43 hake, 10 g juniper, 10 g sanziana, 9 g walnut and 8 g grapefruit pips, after which it is fragmented to dimensions between 0,10 and 0.20 mm. 45

After chopping and sifting the plants, weigh each of the components and mix in stainless steel tanks, by mixing, for the best homogenization. The 47 powdered green matter, thus obtained, is encapsulated or packaged in 200 g bottles with a threaded stopper. 49

RO 127077 Β1

Excess seborrhea is a skin disease caused by excessive secretion of the sebaceous glands and often accompanied by glandular hypertrophy. The sebaceous gland is an exocrine gland from the root of the hair, which secretes sebum, which appears as a fatty matter, of the nature of the seine. This gland is directed by the subcutaneous nerve endings. In the case of nervous dysfunctions, the transmission of nervous information from the central nervous system to the skin level is lost and thus the sebaceous glands no longer function at their normal capacity. The product presented in the invention acts at the subcutaneous level, restoring the nerve pathways and implicitly restoring the function of the sebaceous glands.

It is known that propolis can be used in edema, burns, purples, ecchymoses, but it also contributes to lower cholesterol, it is used in the treatment of scars and burns because it forms a superficial protective layer that allows healing and prevents over-infections, being a powerful anti-infectious. in skin conditions, propolis is effective in eczema, hydrosadinitis, furunculosis, infected wounds, contusions, local staphylococci, beatings, cuts, etc., acting as an anti-inflammatory, as a promoter of antibiotic action, as a local anesthetic, becoming a herbal antibiotic; In the oral cavity it is used as oral antiseptic, being indicated in fungal stomatitis, aphthea, cold sores, Zoster area, allergies and pruritus. Propolis contains flavonic derivatives, feluric acid (active against Gram positive and Gram negative germs), amino acids, balsams, fermenes, microelements: silicon, magnesium, copper, molybdenum, arsenic, tin, vanadium, tungsten, iron, gold, iridium, calcium, cadmium, cobalt, strontium, antibiotics, resins, aromatic acids; depending on the composition and plant species from which it was collected, propolis contains on average 55% resins and conditioners, 30% waxes and 10% ethereal oils.

Hemp seeds (Cannabis sativa) contain psychoactive substances and essential fatty acids omega 3, 6 and 9, proteins that contain all the essential amino acids, but also fibers, calcium, iron, phosphorus, magnesium, sodium, vitamin E, sugars, proteins, carbohydrates. , saturated and unsaturated fats.

In Cannabis sativa, as in other types of cannabis, psychoactive substances also appear, but in a much lower concentration, about 30 times, as: ΤΗΟ-Δ9tetrahydrocannabinol (a psychoactive molecule), cannabinoids sintered from the plant such as: tetrahydrocannabol cannabinol, cannabidiol, cannabinolidic acid, cannabigerol and cannabichromene, Δ-9-tetrahydrocanna-binol. The effects are relaxing.

Aloe vera contains over 75 nutrients and 200 other active ingredients, including: 20 minerals, 18 amino acids and 12 vitamins, over 75 nutrients and microelements, including: calcium, phosphorus, potassium, iron, sodium, manganese , magnesium, copper, chromium, iodine, selenium, zinc, plus 18 amino acids: 7 of the 8 essentials and 11 non-essentials, and vitamins such as: A, B1, B2, PP, B6, B12, C, D, E, citric acid , pantothenic acid, folic acid, azulene, volatile oil, matrix, epigenin, umbeliferone, resins. Aloe vera accelerates and normalizes metabolism, regenerates intestinal villi, detoxifies the body, being antiseptic, anti-inflammatory, stimulates cell regeneration, promotes food absorption, regenerates and strengthens the immune system.

The bay is known to awaken the mind and senses and amplify the subtle perception. At the psychomental level, it activates the state of dynamism, expansion, conferring the specific attitude of the winners. It gives the mind clarity, detachment and measurement, in correlation with the aromatic ethereal taste, related to the content of volatile oil and lactone, which is reflected in a balanced, compliant and moderate, understanding and tolerant attitude. It gives harmony and balance, tempering excesses of any kind. The plant strengthens and sustains the being during difficult times, giving it detachment of disturbances through their understanding and awareness of the inner force, as well as of its own evolutionary potential. He gives himself confidence and dares, urges action

RO 127077 Β1 sharp and fast, determined and focused, removes frustrations and prejudices, takes the being out of 1 routine. It also invigorates, invigorates, instills liveliness, power and dynamism. Daffin contains volatile oils, cineole and phenol, ethers such as: estragol, eugenol, nicotinic acid, mucilages, 3 pectins, tannin, resins, sesquiterpenic lactone of the gremacranolodic type (costunolide).

The product according to the invention is based on natural active substances, existing in 5 plants of the formula such as: carbohydrates, proteins, lipids, calcium, phosphorus, potassium, magnesium, sulfur, sodium, chlorine, iron, copper, manganese, pectin, essential oil, limonene , pineapple, citril, citric acid, 7 alcohols, gallic alcohol, mucilages, pentazones, tannin, glycosides (aucubin), allantoin, vitamins C and K, trioside, phylloquinone, pectin, carotene, plantose, alkaloids such as: chelidonine, spartin, 9 protopine, hemochelidonine, chelerythine, sanghinarine, enzymes, jugladine, oxinaphtoquinone, juglone, tyrosine. 11

The sebaceous glands function in excess, manifestation of excess sebum, due to dysfunction of subcutaneous nerve endings. 13

The product solves several problems, thus, due to the active substances, mentioned below, which act on the regulation of the function of the thymus and pituitary gland, but also of the sebaceous glands, stimulating the brain and subcutaneous glandular activity, finally leading to the regulation and normalization of the functions. sebaceous glands. 17

By stimulating the processes of neutralization of free radicals, it hydrates and nourishes the epidermal cells manifested in the skin. 19

The association in the predetermined reports, of the indigenous plants, presents an increased efficiency, resulting from the mutual enhancement of the components, between which there is a synergy effect, resulting in a cumulative action, regarding the effect on the pituitary and thymus glands, as well as the sebaceous glands, but also antispastic, antirheumatic, anti-bronchial, digestive, 23 hypotensive, hepatic and renal drainage, detoxifying, antiarrhythmic, remineralizing, antiseptic, lowers blood cholesterol, coronary vasodilator, sedative, antitussive, regulates the function of the thyroid gland 25, antianemic, anti-inflammatory, elimination of excess fat and the main effect of the obvious improvement of the health status of the treated organisms, of 27 duration and irreversible, but also without side effects.

Thus, the mutually reinforcing constituents are: antioxidants such as vitamin 29 C from: aloe, bay leaf, walnut, grapefruit, sânziene, rostopască; minerals from: propolis, hemp, aloe, walnut, grapefruit, dandelion, sanziana, rhubarb, bay; volatile oil from: bay, propolis, 31 aloe, juniper; vitamin A from: aloe, juniper; sugars from: hemp, juniper, grapefruit, aloe, propolis; vitamin B from: aloe, walnut; Vitamin E from: hemp, aloe; proteins from: hemp, 33 grapefruit; cellulose made from: walnut, bay, hemp, seagrass, rattlesnake, juniper; but also other substances that enhance the aforementioned elements such as: lactones, carbohydrates, saturated and unsaturated fats, cannabinoids, omega 3, 6, 9, arninoacids with vitamins such as: PP, P, D, K, pantothenic acid, folic acid, azulene, matricine, epigenin, umbeliferone, resins, flavonics, ferulic acid, 37 arninoacids, antibiotics, resins, aromatic acids, balms, waxes, polyvinic acid, tannin, pentazone, phylloquinone, aucobozide, pectin, plantose, cadilic acid, acetic acid, , 39 fumaric acid, oxalic, fatty, nitrogenous, lipid, limonene, pineapple, cipher, pectin, citric acid, chlorophyll, teraxacin, inulin, hydroxycinnamic acid, foil, fat, alkaloids, mannitol, choline, sterols, 41 carotene, what which demonstrate the completion and enhancement of the plant qualities of the anti-sebum product, according to the invention. 43

PHARMACOLOGICAL TESTS

Pharmacodynamic tests performed on voluntary patients indicated a good tolerance of the powdered product 45 and a very good antiseboric activity.

In the biochemical and toxochemical tests performed, there were no 47 side effects.

RO 127077 Β1

Example Seborrhoeic sweat elimination time (days) Age of patients (years) 1 10 30 2 12 41 3 11 20 4 14 45 5 16 18 6 20 43 7 21 60 8 18 54 9 16 48 10 13 53 11 12 32 12 11 56

The tests showed a regulation of fat sweating in maximum 20 days.

The control of raw materials was carried out according to the quality norms of the European Farrnacopeea.

The product is also associated with a menu established according to other diagnoses of the patient.

The dose considered to be effective, according to preliminary tests, was

4 ... 8 capsules daily, taken at equal intervals.

The administration was carried out 15-20 minutes before lunch and evening meals. The product is given in powdered form or capsules. Thus, the capsules or a teaspoon of the powdered product can be ingested with a glass of 50 ... 100 ml liquid. The product can be ingested at any hour of the day, without a certain rigor, it is important that the administration be repeated several times a day, with the recommendation that the administration be about 2 ... 4 times a day and at equal intervals.

TESTS CARRIED OUT

a. Comparison of the claimed product proposed in the invention with respect to product A and with product B

Thus, with the help of the device called Bio-Spectrum (Bioresonance), which reveals in the colors the resonant radiation of the product, the following results were obtained: the following colors appear in the claimed product, in percentages: orange - 20, yellow - 10, green - 20, indigo - 50, compared to product A: green -100, and product B: green - 30, indigo - 70.

The interpretation of colors is as follows: orange - reproduction, yellow - digestive function, green - respiratory and immune function, indigo - function of the central nervous system.

It can be concluded that the product claimed in the invention has a complex of therapeutic and pharmacodynamic effects, starting with the function of reproduction, respiratory, digestive, immune, central nervous system, but also excretory, compared to the product A, which has respiratory and immune function, and product B has respiratory and immune function, but also on the central nervous system.

This test was corroborated with the test regarding the Kirlian effect, in which the three products were also tested, obtaining the following results: the length of the strimers measured for the claimed product, according to the invention, was 3.1. .3.5 mm, for product A, 1.4 ... 1.7 mm, and for product B, 1.9 ... 2.2 mm.

In conclusion, the claimed product has an energy capacity between 75 and 250% higher than products A and B, and in conjunction with the previous test, it can be observed that the therapeutic effect of the claimed product is synergistic and complex, with strong effect on 3 of the digestive tract, nervous system and subcutaneous nerve endings, compared to products A and B. 5

b. Clinical tests

An evaluation of the therapeutic efficacy of the claimed product according to the invention was performed as an adjuvant in the treatment of various disorders associated with diseases.

METHOD 9 Between March and July 2010, 12 volunteer patients, between the ages of 18 and 11 60, of both sexes were monitored and clinically monitored at the phytotherapeutic consultancy.

Patients with skin conditions related to abundant sweating 13 were presented at the clinic.

Patients were presented with the complete medical documentation (paraclinical investigations), 15 as well as with the allopathic therapeutic schemes up to that date. Patients followed the proposed allopathic therapies, supplementing them with the product claimed. All the volunteer patients agreed to complete the treatment with a phytotherapeutic treatment appropriate to their condition. Following the presentation of patients to the office and the corroboration of the anamnestic, clinical and paraclinical data, 19 the adjuvant treatment with the anti-seborrheic product was instituted according to the invention.

Following the administration of the individual treatment schemes (because the 21 acute conditions presented by each patient were taken into account), which involved the accompanying product with other dietary supplements recommended for the respective associated 23 acute diseases, most of the patients have updated their investigations. clinical and paraclinical, so that the clinical observations and laboratory data presented before and after the adjuvant treatment with the product could be compared.

The monitoring period was 90 days, patients presenting to the control every 27 days.

RESULTS 29

Treatment for the elimination of perspiration due to nervous tension, present in the workplace 31

There were tested 4 persons with sweating due to the service, this effect appearing only at the workplace. It has been found that sweating occurs due to nervous tension, 33 present in the workplace. By applying the treatment with the claimed product, 3 times a day, one teaspoon, for a minimum of 10 ... 50 days, it was found that the sweating 35 was gradually eliminated and the nervous system relaxed. The product was well tolerated.

Treatment for eliminating sweating due to obesity 37

There were tested 4 people with low physical activity, over a long period of time, during which there was an obesity due to the lack of movement. Through 39 paraclinical investigations, an advanced decrease in mineralization and vitaminization in the body was found, and a decrease in the urinary tract. By applying the treatment with the claimed product, 41 3 ... 4 times a day, one teaspoon, for a minimum of 3 weeks, a slight elimination of the surplus of weight was found, with approximately 0.5 ... 1 kg per week, 43 elimination of the abundant sweating, finding and solving other health problems, collaterals such as digestion and elimination of liquids through the normal, urinary tract. 45

Treatment for the elimination of perspiration due to confined spaces (claustophobia)

4 people were tested with stress due to the small and closed spaces, during which 47 there was an abundant sweating. By paraclinical investigations, a decrease of the function of the vegetative nervous system was found. By applying the treatment with the product 49

RO 127077 Β1 claimed, 3 to 4 times a day, one teaspoon, for a minimum of 2 weeks to 6 weeks, a gradual elimination of nervous tension, elimination of abundant sweating, finding and solving other problems were found. collateral health such as recovery of stomach function.

CONCLUSIONS

The results obtained in this group of patients demonstrate that the use of the product to treat various problems regarding elimination of sweating has an effect on the pituitary and thymus glands, as well as the sebaceous glands, but it is also antispastic, antirheumatic, antibronic, digestive, hypotensive, hepatic and renal drainage. , detoxifying, anti-arthritic, remineralizing, antiseptic; it also regulates the function of the thyroid gland, being anti-anemic, 11 anti-inflammatory, adjuvant of eliminating excess fat, having many benefits. The properties of the product are due to the active principles of the composition, which act 13 synergies, having calming effects. The body's response to treatment was favorable. There were no adverse reactions.

Claims (1)

Claim 1 Powdered, anti-sebum product, characterized in that it consists of: 8 ... 113 parts leaves of Laurus nobilis, 5 ... 8 parts Cannabis sativa seeds, 8 ... 13 parts Aloe vera, 5 ... 10 parts propolis, 8 ... 13 parts Plantago lanceolata, 9 ... 13 parts Chelidonium majus, 9 ... 135 parts Juniperus communis, 8 ... 12 parts Galium verum, 8 ... 11 parts Juglans Regia, 8 ... 12 parts of Citrus decumana seeds, parts are expressed by weight.7