RO118929B1 - Preparation for treating burns - Google Patents

Abstract

The invention relates to a preparation for treating burns, based on linseed oil, lime water, poplar buds, and consisting of an emulsion comprising 34...39% linseed oil, 33...38% lime water obtained by stirring and 23...33% alcoholic extract of 96...108 parts of poplar buds and 24...27 parts of stinging nettle with 400...500 parts of ethyl alcohol of 85...99°, the parts being expressed by weight.

Description

RO 118929 Β

The invention relates to a preparation for the treatment of burns, which is applied to the affected surface, before or immediately after the appearance of the blisters, intended for therapeutic use.

in the treatment of burns, various compositions are used in which bacteriostatic substances are associated with anesthetics, bactericides, anti-inflammatory and/or other phytopharmaceutical preparations.

Patent RO 65190 describes the association of alcoholic extract of propolis with anesthesin and 96° ethyl alcohol, and patent RO 75 725, the association of qualine chloride, saprosan, azulene and xyline, conditioned in the form of an ointment.

in patent RO 65 633, the regenerative and epithelizing action is given by the association of oxytetracycline with hydrocortisone and propois extract, embedded in an ointment base.

Also known is the product for external use, but with antiherpetic action, obtained from the flavones contained in the poplar bud extract and the terpenes from the mint and thyme oils (RO 81 580).

Other invention patents are also known that describe medicinal combinations, active in the treatment of burns, such as: N-Ag-sulfamethoxydiazine, atomized bentonite and glycerin, with or without the addition of cetylsalicylic alcohol and distilled water (RO 81 262); azulene, ethyl alcohol and anesthetic with deionized water (RO 91 862); mouthwash for the treatment of some diseases of the oral mucosa, in which collagen hydrolyzate is combined with propolis (RO 76103); another medicinal composition was obtained from undenatured collagen gel, sodium salt of dichloroanilinophenylacetic acid and glycerin (RO 97992); another known combination is medicinal powder with antiseptic and cicatrizing action, consisting of neomycin sulfate, polymyxin B-sulfate, metronidazole, allantoin and collagen hydrolyzate (RO 99 845); it is also known of a collagen dressing for the treatment of wounds and burns consisting of fibrous collagen combined with sodium phosphate, sodium chloride, metronodazole and chlorhexidine (RO 103 550).

Currently, a wide range of medicinal products is used for burns, which can be found mentioned in medical directories: silver sulfadiazine (Flamazine, Dermazine), mafenil (Sulfamilon) and betadine (Pavidon iodine), all three being synthetic drugs, which presents some contraindications, then bioxyteracor, with the adverse effects of hydrocortisone in the content, as well as bismuth basic gallate (Dermatol), dequaliunm, clobethazolum (Dermovate) and others.

Many medicinal ointments are also known that combine active principles with anti-inflammatory, cicatrizing and epithelializing action to treat burns, consisting of subnitric bismuth, ichthyium, zinc oxide, camphor, Jecoris oil, vitamin A acetate, vitamin F, ascorbic acid , hydrocortisone acetate, neomycin sulfate, lanolin, petroleum jelly, beeswax, rosin, frankincense, and sunflower oil.

Patent RO 89843 presents a preparation intended for the treatment of burns, consisting of 33% lime water, 34% linseed oil and 33% alcoholic extract from poplar buds, packaged in bottles and mixed at the time of use.

The use of this preparation for the treatment of epithelial lesions, caused by burns, has proven to be effective, but with a longer recovery time of the epidermal damage.

The technical problem, which the preparation according to the invention solves, is to restore in a shorter time the tissues affected by burns, to eliminate the sting and to relieve the pain.

The preparation for treating burns, based on linseed oil, lime water, poplar bud extract, according to the invention, consists in the fact that it consists of an emulsion consisting of

34...39% linseed oil with 33...38% lime water obtained by stirring and 23...33% alcoholic extract obtained from 96...108 parts poplar buds and 24...27 parts nettle high with 400...500 parts ethyl alcohol of 85...99°, the parts being expressed by weight.

RO118929B

The preparation and its use for treating burns have the following advantages:

- quickly restores the affected tissues; 50

- eliminates the production of stings;

- prevents the formation of blisters;

- prevents the infection of already formed fictenas;

- neutralizes the chemical process triggered by tissue contact with the heat source;

- it has no contraindications, it can be administered both to premature babies and to people aged 55 or older;

- it is non-toxic on the surface affected by the burn, has no side effects and does not contain chemical synthesis products.

The preparation that is the subject of this invention is intended for the treatment of superficial and deep burns, being at the same time of choice, for emergency medicine (ATI) in the field of burns, with maximum effectiveness if it is applied within one hour at the most of the accident.

The oleo-limestone liniment is well known since ancient times and was used in the treatment of burns, being also mentioned by the Romanian Pharmacopoeia ed. IX on page 431, and lime water is also mentioned by F. R. ed. X/2000, at page 1211. 65

The use of the two medicinal plants: poplar buds (Populli gemae) and nettle (Urtica dioica) are known from specialist monographs in the field. Thus, the medical agenda for 1997 presents an antihemorrhoidal ointment in which poplar buds are included, and Farmacia naturii by F. Crăciun, O. Bojor and M. Alexan in you. I, Ed. Ceres, Bucharest, 1976, mentions on page 86, regarding them an "astringent, antiseptic, 70 slightly anti-inflammatory and slightly analgesic action ¹ '.

The same work on page 95 describes nettle (Urtica dioica) and mentions its actions: "hemostatic, astringent, hematopoietic, mildly hypoglycemic, diuretic or antiseptic externally and stimulator of epithelization of the skin. The aqueous extract inhibits the development of various pathogens (Shigella, Staphilococcus, Pasteurela, etc.)". 75

The component elements of the preparation for the treatment of burns are represented by a chemical substance, namely the oleo-limestone liniment, which has passed the test of time as a medicine for burns, and a natural alcoholic extract from two medicinal plants: poplar buds and the aerial part of nettle; this association in the mentioned report, achieves a remarkable synergism of the ingredients, without adverse effects and without contraindications. 80

The chemical composition of the medicinal plants used is responsible for the beneficial effect against burns;

a) The chemical composition of black poplar buds is as follows:

- 0.5% essential oil rich in caryophyllene (C ₁₅ H ₂₄ ) and other sesquiterpenes, as well as

- the phenolic glycosides, salicin (C ₁₃ H _1e O ₂ ) and populin (C ₂₀ H ₂₂ O ₈ ) and 85

- flavonic compounds (chrysin C ₁₅ H _W O ₄ , tectochrysin C ₁₆ H ₁₂ O ₄ ), etc.

The description of the chemical composition of poplar buds is according to the treatise Medicinal and aromatic plants, by Evdochia Cocîu and Gabriel Racz, pages 492-494.

b) From the nettle, the aerial parts or only the leaves can be used. in its chemical composition the presence of ketones was described: methylheptenone (C ₈ H ₁₄ O) and acetophenone 90 (C _a H ₈ O), methyl derivative of phenyl ketone.

The presentation of the chemical composition is in accordance with the same treatise on medicinal and aromatic plants, pages 565 - 567.

Stinging nettle is used externally, both in the cosmetic industry and in dermatology to stimulate wound healing, as well as in the treatment of varicose veins of the calf and in oto-rhino-laryngology. 95

The hemostatic action of nettle is attributed to its vitamin K content.

RO 118929 Β

The preparation is considered as a product rich in vitamins. The content in provitamin A (beta-carotene, C ₄₀ H _5B ) is 0.02 - 0.04 %, in vitamin B2 (lactoflavin, C ₁₂ H _1B ON ₄ S) is about 0.00153 %, in acid pantothenic (C ₉ H ₁₇ O ₅ N) of about 0.001%, in vitamin K (C ₃₎ H ₄₆ O ₂ ) of about 400 biological units per gram. The chlorophyll content is 0.3 - 1% based on the dry weight of the leaves.

The antimicrobial action was presented for the aqueous extract, but it was found experimentally on the treated patients, that the antiseptic effect also has the alcoholic extract.

c) with regard to the ethanol content, it is known that in hospital emergency rooms, as usual, undiluted 700° alcohol is used for first aid, and surgical treatises prescribe this use. The irritating effect of alcohol is however suppressed by the use of alcohol as a natural extract, associated with the oleo-limestone emulsion.

The preparation is used to treat superficial and deep burns. It complements the range of drugs currently used to treat burns (for emergency first aid, it can be used by rescue stations even at home).

By using this preparation, it is not necessary to interrupt other medicinal therapies for internal use, nor to surgically remove the unbroken filaments, as they constitute a protective layer until the lesion is healed (like a heterotransplantation). The anti-inflammatory effect of the preparation is considered to be sufficient to avoid infection of unbroken phlicten.

The preparation has no contraindications for immediate or delayed application (however, it is preferable to apply it as soon as possible after the occurrence of the combustion accident), neither from the point of view of the patient's age, nor from the point of view of the state of health.

If the thermally attacked tissue still preserves a certain degree of vitality, i.e. unbroken phlictenes or portions where the phlictenes have not yet risen and the treatment is applied immediately (within an hour at the latest), it recovers very quickly (within a few hours ) the initial integrity almost entirely (as if these portions had not been subjected to a thermal source).

The faster the application time, the more heat damaged areas (that still have viable portions) can recover. in this way, the surface area of the burns can be substantially reduced in a few hours, decreasing the lethality of burns with large affected areas.

For chemical burns, the effects are identical, provided that a neutralizer of the corrosive agent is applied immediately, before applying the preparation.

The high analgesic capacity of the preparation was found in first, second and third degree burns, where the internal or local administration of other anesthetics is no longer necessary, thus avoiding their adverse effects. in certain cases, anesthetic substances may be contraindicated, and this preparation eliminates the stings, avoiding the appearance of others, and it is possible to get the patient out of the pain shock.

At the same time, it avoids the evolution of the burn to great suffering of the internal organs (in the foreground finding the kidney from shock) or to exitus.

The fact that the pain is almost completely reduced within 1 - 4 h for first and second degree burns, and in about 12 h for third degree burns, presents a particular advantage, especially when treating cardiac patients or premature babies, who are much more vulnerable to pain when the burns are on large areas of the body. in the emergency therapy of burns, it is necessary to take into account that golden hour when intervention is necessary, before the appearance of hemodynamic disorders.

in the case of the immediate treatment of external combustion aggressions, destructive local chemical reactions are inhibited, through a complex of local anti-thermal and anti-inflammatory actions, which leads to the avoidance of new flare-ups and the remission of existing ones.

RO118929B

The antiseptic capacity of the synergistic components of the preparation, as well as the rapid healing, lead to the recovery of the burned areas that present raised and unremoved blisters, without signaling their infection.

The preparation substantially reduces plasmorrhagia of open wounds; it is no longer necessary to open the blisters, and the surface of the wounds does not increase compared to the already existing ones, and thus the volume of plasmorrhage is reduced. 150

Example. below, the method of making the preparation is presented:

1) prepare the oleo-limestone liniment from 34-39% linseed oil and 33-38% lime water, by stirring;

2) the alcoholic extract is prepared by macerating poplar buds and nettle aerial parts in ethyl alcohol for 18 days, in the following proportions: 155

- 400 - 500 ml ethyl alcohol of 85 - 90°;

- 92 - 108 grams of poplar buds (dried); and

- 23 - 27 grams nettle (dry);

3) the oleo-limestone liniment and the alcoholic extract, conditioned in separate containers, are mixed only at the time of use, stirring for good homogenization, in the following proportions:

- oleo-limestone liniment 67 - 77%;

- alcoholic extract of poplar buds and nettle 23 - 33%.

How to apply the preparation for treating burns, it can be done by anointing the affected areas, every time the patient starts to feel a sting. This 165 way of use is especially indicated for burns on large areas of the body.

On the small surfaces of the extremities of the body, it is recommended to use compresses. Care must be taken to permanently ensure a thermal gradient as high as possible. For this reason, compresses must be well soaked and will not be covered with waterproof materials that stop air exchange. 170

If it is possible to expose them to a current of cold air, it is good to proceed as such, to facilitate heat exchanges between the burning surface and the external environment.

Administration of the preparation is optional for the first 24 hours.

In burns with open wounds, caution is needed to ensure local 175 asepsis.

In crusted wounds caused by electrocution burns, the preparation can be used until final healing, but with careful supervision regarding asepsis. For this type of burn, the specialized literature recommends a local surgical toilet, after which an early grafting is done. 180

With the preparation for burns, curettage of necrotic areas and grafting can be dispensed with, obviously with some exceptions appreciated by the treating physician. Impregnating and asepticizing the electrocuted areas with this preparation makes it possible to maintain the crusts (or calluses) as a protective layer, until complete healing, without the risk of suppuration.

The way to preserve the preparation over time is as follows: the liniment will be stored 185 in brown glass containers, hermetically sealed, in refrigerators, where the temperature does not drop below one degree.

The alcoholic extract can be stored at room temperature and does not lose its validity over time.

The shelf life for the liniment is about 12 months. 190

The preparation is packaged in vials that are mixed at the time of use.

Despite all the controversies related to the instability of the final preparation, paradoxically, it was found that it has a much longer shelf life than the liniment without the addition of alcoholic extract, reaching years, without diminishing its therapeutic qualities during this time . 195

Claims (1)

RO 118929 Β Claim Preparation for the treatment of burns, based on linseed oil, lime water, poplar bud extract, characterized by the fact that it consists of an emulsion consisting of 34...39% 200 linseed oil with 33...38% lime water obtained by stirring and 23...33% alcoholic extract obtained from 96...108 parts poplar buds and 24...27 parts nettle with 400.. .500 parts ethyl alcohol of 85...99°, the parts being expressed by weight. The president of the examination committee: Eng. Mirela Georgescu Examiner: Dr. med. vet. luliana-Emilia Moroianu Editing and computerized techno-editing - OSIM Printed at: State Office for Inventions and Trademarks