RO115697B1 - Process for preparing a phytotherapeutic complex for the treatment of teguments and mucous membranes - Google Patents

Abstract

According to the invention, the process consists in that, during a first step, the mixture of Radix Bradanae, Herba Echinacea and Turio Pini (17:166:166) is extracted, in a first phase, with 5 parts of 40‹ ethanol by mechanical agitation for 3 hours, at the ambient temperature, and in a second phase with 25 parts of 40‹ ethanol by refluxing, at the temperature of 5560‹C, then the solutions are mixed together; during the second step, the mixture of Herba Salviae, Herba Basilici (166:166) is extracted, in a first phase, in the same conditions as in the first step, and in a second phase with 25 parts of 70‹ ethanol, in the same conditions as in he first step; during the third step the aqueous phase from 166 parts of defrosted Folium Aloe is separated and extracted, in a first phase, with 5 parts of 70‹ ethanol for two hours, at the ambient temperature, and in the second phase with 25 parts of 70‹ ethanol for 1 hour, then the three extracting solutions so obtained are mixed, settled for 6 days at 510‹C and finally filtered, the parts being expressed by weight

Description

The present invention relates to a process for obtaining a phytotherapeutic complex for the treatment of skin and mucous membranes, intended for the treatment of conditions such as, acne, aphthea, candidiasis, herpes simplex.

In the literature there are known processes for obtaining plant extracts used in dermatology, such as the process consisting of a mixture of Radix Symphytum, Flos Calendula, Folium Juglans, Turio Pini plants, macerated at room temperature, in 80 ° ethanol and the alcoholic extract are refluxed for 8 ... 10 hours with 37% formaldehyde, 37% hydrochloric acid and 8-hydroxyquinoline, after which the product is isolated by distillation of excess alcohol - water.

The process of obtaining the phytotherapeutic complex according to the invention consists in the fact that, in the first stage, the mixture of Radix Bradanae, Herba Echinacea and Turio Pini (17: 16.6: 16.6) is extracted in the first phase with 5 parts ethanol 40 °. , by mechanical stirring at room temperature, for 3 hours, and in the second phase with 2.5 parts ethanol 40 °, by refluxing at 55 ... 60 ° C, then the solutions are mixed; In the second stage, the mixture of Herba Salviae, Herba Basilici (16.6: 16.6) is extracted, in the first phase under the conditions of the first stage, and in the second phase with 2.5 parts 70 ° ethanol, under the same conditions as in the first stage; In the third stage, from 16.6 parts, thawed Folium Aloe separates the aqueous phase which, in the first phase, is extracted with 5 parts 70 ° ethanol, at room temperature, for 2 hours, and in the second phase with 2.5 parts ethanol 70 °, for 1 h, mix the three extractive solutions obtained, sediment 6 days, at 5 ... 10 ° C and filter, the parts being expressed by weight.

The advantage of the invention is that the process is easy to perform and leads to obtaining a product with anti-inflammatory, antiseptic, antimycotic, antiviral, immunomodulatory, healing, anesthetic effect.

The following is an example of an embodiment of the invention.

For 1 product, 35 g of the proposed vegetable products are required.

5.95 g Radix Bardanae (burns), 5.81 g Echinacea grass, 5.81 g Turio Pines (pine cones), coarsely chopped, mix in a bowl with shaker, heating and refrigerant and extract with 525 ml of 40 ° ethyl alcohol by mechanical stirring at room temperature for 3 hours; after separation of the extractive solution, the semi-blended mixture is extracted with 265 ml of 40 ° ethyl alcohol, by refluxing at 55 ... 60 ° C, for 2 hours; the separate extraction solution meets the precedent. further 5.81 g Herba Salviae (jales) and 5.81 g Herba Basilici (basil), coarsely chopped, mix in a bowl with shaker, heating and refrigerant and extract with 350 ml of ethyl alcohol of 70 °, by mechanical stirring, at room temperature, for 3 hours; after separation of the extractive solution, the semi-purified mixture is extracted with 175 ml of 70 ° ethyl alcohol, by refluxing, at 55 ... 60 ° C, for 2 hours; the separate extraction solution meets the precedent.

Then 5.81 g Folium Aloe, chopped, is frozen; the aqueous part is separated, after thawing, and the extracted plant is extracted by mechanical stirring, at room temperature with 175 ml of 70 ° ethyl alcohol, for 2 h. After the extraction solution is separated, the residue is further extracted in a similar way with 90 ml of alcohol. ethyl 70 °, for 1 h. The two extracts are mixed.

The 3 extraction solutions obtained as above are combined and after sedimentation, for 6 days at 5 ... 10 ° C, are filtered.

Using the vegetable raw materials from different batches, by the process according to the invention, in 3 samples, the following quantitative average results were obtained: 45% (w / w) alcohol, 0.17% (w / w) evaporation residue, 0.366% (g / g) bitter principles. The organoleptic characteristics and identification reactions were identical.

Claims (1)

Claim Process for obtaining a phytotherapeutic complex for the treatment of teguments and mucous membranes, characterized in that, in the first stage, the mixture of Radix Bradanae, Herba Echinacea and Turio Pini (17: 16.6: 16.6) is extracted, in the first phase, with 5 parts ethanol 40 °, by mechanical stirring, at room temperature, for 55 3 h, and, in the second phase, 2.5 parts ethanol 40 ° by refluxing at room temperature 55 ... 6d ° C, then the solutions are mixed; in the second stage, the mixture of Herba Salviae, Herba Basilici (16.6: 16.6) is extracted, in the first phase under the conditions of the first stage, and, in the second phase, with 2.5 parts 70 ° ethanol under the same conditions as in the first stage; In the third stage of 16.6 parts thawed Folium Aloe, the aqueous phase is separated, which, in the first 60 phase, is extracted with 5 parts ethanol 70 °, at room temperature, for 2 hours, and in the second phase by 2, 5 parts ethanol 70 °, for 1 h, mix the three extractive solutions obtained, settle for 6 days at 5 ... 10 ° C and filter, the parts being expressed by weight.