RO106503B1 - Ointment for wounds cicatrizinc and other cutaneous lesions - Google Patents

Abstract

The invention relates to an ointment for scarring wounds and other injuries skin, for the treatment of all wounds superficial skin, wounds, ulcers trophic, grade I, II, III and other burns skin lesions such as pyoderma, escales, dermatoses professional, eczema, allergic dementia, radiodermets, infected dermatoses, shingles, some forms of psoriasis, etc. The ointment is constituted of: nitroglycerin, dermatol, mafenide, Hydrocortisone Acetate, Peru Balsam, Vitamin E, vitamin F, vitamin A, incorporated into a base of simple ointment. Ointment is based on activity antiseptic, antiallergic, anti-inflammatory, anti-exudative and epithelizing on complex action, synergistically, of the active substances it contains.

Description

The present invention relates to an ointment for the healing of wounds and other skin lesions, intended for the treatment of all superficial skin wounds, atonic wounds, trophic ulcers, grade I, II, III burns and other skin lesions, such as pyodermitis, ladders. , professional dermatitis, eczema, radiodermitis, allergic dermatitis, infected dermatoses, herpes, shingles, some forms of psoriasis, etc.

Currently, ointments, creams, powders, sprays, which contain 1-2 active substances, usually cortisone and / or antibiotic products, sulphonamides, hematite powder, sea buckthorn oil are used for the treatment of the above mentioned skin lesions. These products, manufactured in the country or imported are: bioxiteracor spray, decaderm, nidoflor, nebacetim, cicatrol, dermovate, vipsogal, rombalsam, cutaden, asorian, negamicin B, pivalent fluomelazon, locacorten with neomicyn TAR, sulfamylon, fluocinolone, synal ul live a year, tunisia, neopreol, hydrocortisone ointment, tetracycline ointment, triamcinolone acetonide ointment, with or without saprosan, vitamin A acetate ointment, jecolan, jecozinc, hematite powder, debrisan etc.

A drug composition known for dermatoses, wounds and burns is known, which is constituted by the combination of diphenolic reducing substances, chosen from pyrocatechin, resorcin or hydroquinone; hydroxyacids, selected from citric acid, tartaric acid or lactic acid, amino acids, selected from cysteine, lysine, methionine or asparagine; phenolic acids, selected from acetylsalicylic acid, benzoic acid, salicylic acid, antifungal substance, chosen from nystatin, chlorchinaldol, infusible extract of Matricaria Chamomilla or Hypericum perforatum, propylene glycol, stabilizing agent, aromatizing agent, hydrochloric acid 10%, ethanol, water.

All of these products, taken individually or in combination, act on a limited number of dermatoses, or target only partial treatments.

The present invention removes the disadvantages shown, making a complex product, with increased efficiency, which leads to rapid epithelialization, by associating the following active components with synergistic action: 0.03% nitroglycerin, 7% dermatol, 10% mafenid, 0 , 7% hydrocortisone acetate, 7% balsam from Peru, 1% vitamin E, 10% vitamin F, 1,000,000 international units retinol acetate and simple ointment up to 100%, the percentages being expressed by weight.

The invention has the following advantages:

- sum up the synergistic, healing actions of several active principles, speeding up the healing (epithelialization) of skin wounds, burns and other skin lesions, faster than other known drugs;

- improves the local circulation, with anti-inflammatory and anti-inflammatory effect;

- the ointment is strongly antiseptic and anti-allergic, which makes it indicated in most septic and allergic skin lesions;

- keeps its effectiveness for a long time.

The following is an example of an embodiment of the invention:

Stir together 0.03 g nitroglycerin, 7 g dermatol, 10 g mafenide, 0.7 g hydrocortisone acetate, 7 g Peru balsam, lg vitamin E, 10 g vitamin F, 1,000,000 international units retinol acetate and up to 100 g unguentum simplex, consisting of 10 g anhydrous lanolin and 90 g white petroleum jelly. The result is a homogeneous-looking, pleasant-smelling ointment that is kept tightly closed, protected from light, in a cool (or cold) place, in glass, plastic or sealed containers.

The ointment bases its antiseptic, antiallergic, anti-inflammatory, anti-inflammatory and healing (epithelializing) effect on the complex, cumulative action of the active substances it contains.

The hydrocortisone stimulates epithelial regeneration by its local tissue anabolic effect and by inhibiting the proliferation of connective granulation tissue, while also having a strong anti-inflammatory, antiallergic and antiexudative effect.

Vitamin A, Vitamin E and Vitamin F contribute to synergy and metabolism and trophicity of the skin, stimulating epithelialization and healing, respectively, of most skin lesions. Vitamin E, by its antioxidant effect, contributes to the long-term conservation of vitamins A and F and other active substances based on ointment.

Dermatol, in addition to the astringent, anti-inflammatory and healing effect, also has a slight antiseptic effect.

Mafenid has a strong antiseptic effect.

The balm of Peru has a well-known healing effect.

Nitroglycerin (which can be replaced with isosorbide dinitrate) by its local vasodilator effect has multiple beneficial effects. First, it increases the local tissue trophic effect of the other ingredients in the ointment, useful for healing. Secondly, marked vasodilation leads to a wound surplus of oxygen and multiple nutrients useful for healing. Thirdly, it speeds up the healing, because vasodilation, predominantly venular, accelerates the local circulatory flow and thereby reduces edema and eliminates toxic substances: acid radicals, serotomine, bradykinin, prostaglandins, altered proteins, etc. . The extremely low concentration follows only its local vasodilator effect, without general side effects, the most frequent being headache, through its resorption, which requires caution in the case of very large areas of burns, in children under 10 years, in the elderly with cerebral atherosclerosis and in the case of glaucoma, although this possible incident has not been encountered.

The simple ointment is an inert ointment base, which preserves all the mentioned active substances well, provided that the anhydrous lanolin and white petroleum jelly are pure chemicals, well kept and free from impurities.

Therefore, all these active substances act synergistically, favoring the healing of skin wounds, burns and other mentioned skin lesions. All the ingredients, between which there is no incompatibility, are very well dispersed in lanolin and petroleum jelly.

The theoretical argument based on the fact that the local vasodilator action of nitrogiicerin would have an unfavorable action in the case of burns and other hot wounds with acute inflammatory process, does not have confirmation in practice in thousands of cases, the explanation being that the favorable effects of nitroglycerin, by the mechanisms pharmacological and pathophysiological mentioned above, cancel the possibility of possible adverse effects in such cases. Also, the theoretical argument based on the fact that lanolin and petroleum jelly prevent the skin from breathing and, therefore, would oppose epithelialization, has no confirmation in practice, since the results obtained in thousands of cases with this ointment are very good, superior to all existing products in the present moment.

Claims (1)

Ointment for healing of wounds and other skin lesions, characterized by the fact that it consists of the synergistic association of: 0.03% nitroglycerin, 7% dermatol, 10% mafenide, 0.7% hydrocortisone acetate, 7% balsam from Peru, 1% vitamin E, 10% vitamin F, 1,000,000 international units retinol acetate and simple ointment up to 100%, the percentages being expressed by weight. Group 4