PT999828E - PROCESS FOR THE PRODUCTION OF PREPARATIONS OF ACTIVE SUBSTANCE WITH CONTROLLED LIBERATION FROM A MATRIX - Google Patents
PROCESS FOR THE PRODUCTION OF PREPARATIONS OF ACTIVE SUBSTANCE WITH CONTROLLED LIBERATION FROM A MATRIXInfo
- Publication number
- PT999828E PT999828E PT98943632T PT98943632T PT999828E PT 999828 E PT999828 E PT 999828E PT 98943632 T PT98943632 T PT 98943632T PT 98943632 T PT98943632 T PT 98943632T PT 999828 E PT999828 E PT 999828E
- Authority
- PT
- Portugal
- Prior art keywords
- matrix
- preparations
- production
- active substance
- active ingredient
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A process for preparing a controlled release composition with a controlled release matrix and containing a pharmaceutically active ingredient, which comprises granulating the active ingredient with a molten matrix material or with a matrix material while it is being melted and with optional additional inactive materials at a first elevated temperature, then cooling and screening the granulate, forming a fluidized bed of the resulting material at a second elevated temperature, and recovering the resulting product; and the product formed by the process.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19729487A DE19729487A1 (en) | 1997-07-10 | 1997-07-10 | Process for the preparation of active ingredient preparations with controlled release from a matrix |
Publications (1)
Publication Number | Publication Date |
---|---|
PT999828E true PT999828E (en) | 2004-02-27 |
Family
ID=7835229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT98943632T PT999828E (en) | 1997-07-10 | 1998-07-01 | PROCESS FOR THE PRODUCTION OF PREPARATIONS OF ACTIVE SUBSTANCE WITH CONTROLLED LIBERATION FROM A MATRIX |
Country Status (11)
Country | Link |
---|---|
US (1) | US6103264A (en) |
EP (1) | EP0999828B1 (en) |
JP (1) | JP2002511095A (en) |
AT (1) | ATE250410T1 (en) |
AU (1) | AU9151398A (en) |
CA (1) | CA2242552C (en) |
DE (2) | DE19729487A1 (en) |
DK (1) | DK0999828T3 (en) |
ES (1) | ES2207856T3 (en) |
PT (1) | PT999828E (en) |
WO (1) | WO1999002134A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1312058B1 (en) * | 1999-04-09 | 2002-04-04 | Pharmaplus S R L | METHOD FOR MICRO-ENCAPSULATION OF MEDICATIONS. |
DE10029201A1 (en) | 2000-06-19 | 2001-12-20 | Basf Ag | Retarded release oral dosage form, obtained by granulating mixture containing active agent and polyvinyl acetate-polyvinyl pyrrolidone mixture below the melting temperature |
MXPA06005913A (en) * | 2003-12-04 | 2006-06-27 | Pfizer Prod Inc | Azithromycin multiparticulate dosage forms by liquid-based processes. |
CA2547597A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate compositions with improved stability |
US6984403B2 (en) * | 2003-12-04 | 2006-01-10 | Pfizer Inc. | Azithromycin dosage forms with reduced side effects |
CN1889931A (en) * | 2003-12-04 | 2007-01-03 | 辉瑞产品公司 | Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride |
WO2005053639A2 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Controlled release multiparticulates formed with dissolution enhancers |
ES2308274T3 (en) * | 2003-12-04 | 2008-12-01 | Pfizer Products Inc. | PROCEDURE FOR MANUFACTURING MULTIPARTICULATE PHARMACEUTICALS. |
BRPI0417348A (en) * | 2003-12-04 | 2007-03-13 | Pfizer Prod Inc | spray gelatinization process using an extruder for preparing multiparticulate crystalline drug compositions preferably containing a poloxamer and a glyceride |
WO2005053652A1 (en) | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride |
US20060204613A1 (en) * | 2005-02-18 | 2006-09-14 | Castro Armando J | Chewing gum containing flavor delivery systems |
US20060286200A1 (en) * | 2005-04-18 | 2006-12-21 | Castro Armando J | Confections containing flavor delivery systems |
RU2007143556A (en) * | 2005-04-25 | 2009-06-10 | ТЕВА ФАРМАСЬЮТИКАЛЗ ЮЭсЭй, ИНК. (US) | PROLONGED RELEASE COMPOSITIONS |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3080293A (en) * | 1960-08-02 | 1963-03-05 | Hoffmann La Roche | Process of making pleasant-tasting niacinamide beadlets |
DE1617593A1 (en) * | 1965-10-12 | 1971-04-29 | Leo Pharm Prod Ltd | Method of making tablets or pills |
JP2681373B2 (en) * | 1988-07-18 | 1997-11-26 | 塩野義製薬株式会社 | Method for manufacturing sustained-release preparation |
WO1993007859A1 (en) * | 1991-10-23 | 1993-04-29 | Warner-Lambert Company | Novel pharmaceutical pellets and process for their production |
SE9200858L (en) * | 1992-03-20 | 1993-09-21 | Kabi Pharmacia Ab | Method for producing delayed release pellets |
NZ260408A (en) * | 1993-05-10 | 1996-05-28 | Euro Celtique Sa | Controlled release preparation comprising tramadol |
DK0654263T3 (en) * | 1993-11-23 | 2002-04-29 | Euro Celtique Sa | Process for the preparation of a sustained release preparation |
EP0672416A1 (en) * | 1994-03-14 | 1995-09-20 | Euro-Celtique S.A. | Pharmaceutical composition comprising diamorphine |
-
1997
- 1997-07-10 DE DE19729487A patent/DE19729487A1/en not_active Withdrawn
-
1998
- 1998-07-01 PT PT98943632T patent/PT999828E/en unknown
- 1998-07-01 EP EP98943632A patent/EP0999828B1/en not_active Expired - Lifetime
- 1998-07-01 JP JP50798399A patent/JP2002511095A/en not_active Ceased
- 1998-07-01 DK DK98943632T patent/DK0999828T3/en active
- 1998-07-01 AU AU91513/98A patent/AU9151398A/en not_active Abandoned
- 1998-07-01 WO PCT/DE1998/001811 patent/WO1999002134A2/en active IP Right Grant
- 1998-07-01 ES ES98943632T patent/ES2207856T3/en not_active Expired - Lifetime
- 1998-07-01 DE DE59809737T patent/DE59809737D1/en not_active Expired - Lifetime
- 1998-07-01 AT AT98943632T patent/ATE250410T1/en active
- 1998-07-07 US US09/110,709 patent/US6103264A/en not_active Expired - Lifetime
- 1998-07-09 CA CA002242552A patent/CA2242552C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1999002134A3 (en) | 1999-05-14 |
ATE250410T1 (en) | 2003-10-15 |
EP0999828B1 (en) | 2003-09-24 |
CA2242552C (en) | 2002-02-05 |
CA2242552A1 (en) | 1999-01-10 |
WO1999002134A2 (en) | 1999-01-21 |
EP0999828A2 (en) | 2000-05-17 |
DE19729487A1 (en) | 1999-01-14 |
DK0999828T3 (en) | 2004-01-19 |
ES2207856T3 (en) | 2004-06-01 |
AU9151398A (en) | 1999-02-08 |
JP2002511095A (en) | 2002-04-09 |
DE59809737D1 (en) | 2003-10-30 |
US6103264A (en) | 2000-08-15 |
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