PT98638A - Method for the preparation of borsoline derivatives - Google Patents

Method for the preparation of borsoline derivatives

Info

Publication number
PT98638A
PT98638A PT9863891A PT9863891A PT98638A PT 98638 A PT98638 A PT 98638A PT 9863891 A PT9863891 A PT 9863891A PT 9863891 A PT9863891 A PT 9863891A PT 98638 A PT98638 A PT 98638A
Authority
PT
Portugal
Prior art keywords
borsoline
derivatives
preparation
method
Prior art date
Application number
PT9863891A
Other languages
Portuguese (pt)
Other versions
PT98638B (en
Inventor
Rainer Metternich
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB909017694A priority Critical patent/GB9017694D0/en
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of PT98638A publication Critical patent/PT98638A/en
Publication of PT98638B publication Critical patent/PT98638B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
PT9863891A 1990-08-13 1991-08-12 Method for the preparation of borsoline derivatives PT98638B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB909017694A GB9017694D0 (en) 1990-08-13 1990-08-13 Improvements in or relating to organic chemistry

Publications (2)

Publication Number Publication Date
PT98638A true PT98638A (en) 1992-06-30
PT98638B PT98638B (en) 1999-01-29

Family

ID=10680563

Family Applications (1)

Application Number Title Priority Date Filing Date
PT9863891A PT98638B (en) 1990-08-13 1991-08-12 Method for the preparation of borsoline derivatives

Country Status (17)

Country Link
EP (1) EP0471651A3 (en)
JP (1) JP2539965B2 (en)
KR (1) KR920004416A (en)
AU (1) AU643312B2 (en)
CA (1) CA2048953A1 (en)
CS (1) CS248491A3 (en)
FI (1) FI913788A (en)
GB (1) GB9017694D0 (en)
HU (1) HUT59161A (en)
IE (1) IE912841A1 (en)
IL (1) IL99163A (en)
MX (1) MX9100628A (en)
NZ (1) NZ239359A (en)
PT (1) PT98638B (en)
RU (1) RU2075481C1 (en)
TW (1) TW275634B (en)
ZA (1) ZA9106393B (en)

Families Citing this family (66)

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US5574014A (en) * 1988-04-28 1996-11-12 Thrombosis Research Institute Inhibitors of trypsin-like enzymes
US6313096B1 (en) 1988-04-28 2001-11-06 Trigen Limited Inhibitors of trypsin-like enzymes
US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
MX9206628A (en) * 1991-11-22 1993-05-01 Boehringer Ingelheim Pharma Prolinaboronato ester and method for its preparation.
AT158588T (en) * 1992-04-16 1997-10-15 Zeneca Ltd Peptides with a alphaaminoboronaire group and their use as elastase
FR2701951B1 (en) * 1993-02-24 1995-06-09 Adir New peptide derivatives of boronic acid, their process for the preparation and pharmaceutical compositions containing them.
WO1994020526A1 (en) * 1993-03-03 1994-09-15 Sandoz Ltd. Peptide boronic acid derivatives having protease inhibiting activity
US5563127A (en) * 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
AU6448794A (en) * 1993-03-24 1994-10-11 Du Pont Merck Pharmaceutical Company, The Boronic acid and ester inhibitors of thrombin
US5780631A (en) * 1993-06-03 1998-07-14 Astra Aktiebolag Starting materials in the synthesis of thrombin and kininogenase inhibitors
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
SE9301916D0 (en) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
IL111176D0 (en) * 1993-10-07 1994-12-29 Du Pont Merck Pharma Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them
IL111175D0 (en) * 1993-10-07 1994-12-29 Du Pont Merck Pharma Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them
WO1995009859A1 (en) * 1993-10-07 1995-04-13 The Du Pont Merck Pharmaceutical Company Boropeptide inhibitors of thrombin which contain a substituted pyrrolidine ring
US5462964A (en) * 1993-10-20 1995-10-31 The Du Pont Merck Pharmaceutical Company Dipeptide boronic acid inhibitors of trypsin-like enzymes
US6060462A (en) * 1993-10-20 2000-05-09 Dupont Pharmaceuticals Company Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
GB9401483D0 (en) * 1994-01-26 1994-03-23 Sandoz Ltd Organic compounds
US5693617A (en) * 1994-03-15 1997-12-02 Proscript, Inc. Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
DE4421052A1 (en) 1994-06-17 1995-12-21 Basf Ag New thrombin inhibitors, their preparation and use
FR2721611B1 (en) * 1994-06-22 1996-09-27 Adir New peptide derivatives of boronic acid, process for their preparation and pharmaceutical compositions containing them.
US5510369A (en) * 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
SE9404196D0 (en) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
BR9607582A (en) * 1995-02-17 1998-07-07 Basf Ag Peptide and peptidomimetic compound or substance
US5629324A (en) * 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
DE69624365T2 (en) 1995-07-26 2003-06-26 Mitsubishi Chem Corp Penizillaminamid derivatives
GB9515489D0 (en) * 1995-07-28 1995-09-27 Sandoz Ltd Organic compounds
TWI238827B (en) 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
FR2745288B1 (en) * 1996-02-27 1998-04-17 Adir New derivatives of boronic acid, their process for the preparation and pharmaceutical compositions containing them
US5965532A (en) 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6004955A (en) * 1996-08-15 1999-12-21 Dupont Pharmaceuticals Company Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists
CA2268270A1 (en) * 1996-10-11 1998-04-23 Cor Therapeutics, Inc. Heterocyclic derivatives as factor xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6063794A (en) * 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
AU743735B2 (en) * 1996-10-11 2002-02-07 Millennium Pharmaceuticals, Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
CA2268264A1 (en) * 1996-10-11 1998-04-23 Cor Therapeutics, Inc. Selective factor xa inhibitors
US5798377A (en) * 1996-10-21 1998-08-25 Merck & Co., Inc. Thrombin inhibitors
AU6896398A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
CA2285335A1 (en) 1997-04-14 1998-10-22 Cor Therapeutics, Inc. Selective factor xa inhibitors
CA2285705A1 (en) * 1997-04-14 1998-10-22 Cor Therapeutics, Inc. Selective factor xa inhibitors
NZ500353A (en) 1997-04-14 2002-02-01 Cor Therapeutics Inc Cyclic diaza compounds that are selective inhibitors of factor Xa
US6100234A (en) 1997-05-07 2000-08-08 Tufts University Treatment of HIV
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
EE9900584A (en) 1997-06-19 2000-08-15 Dupont Pharmaceuticals Company Factor Xa inhibitors of neutral P1 spetsiifilisusrühmaga
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
ES2285785T3 (en) 1997-09-29 2007-11-16 Point Therapeutics, Inc. Stimulation of in vitro hematopoyetic cells.
JP2002501081A (en) 1998-01-26 2002-01-15 ビーエーエスエフ アクチェンゲゼルシャフト Thrombin inhibitors
CA2333927A1 (en) 1998-04-01 1999-10-07 Dupont Pharmaceuticals Company Pyrimidines and triazines as integrin antagonists
CA2331122A1 (en) 1998-05-04 1999-11-11 Point Therapeutics, Inc. Hematopoietic stimulation
DK1084129T3 (en) 1998-06-05 2003-05-19 Point Therapeutics Inc Cyclic boroProline Compounds
AU3127900A (en) 1998-12-23 2000-07-31 Du Pont Pharmaceuticals Company Thrombin or factor xa inhibitors
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
AU3076402A (en) * 2000-12-13 2002-06-24 Bristol Myers Squibb Pharma Co Imidazolidinones and their related derivatives as hepatitis virus ns3 proteaseinhibitors
JP2004516286A (en) 2000-12-18 2004-06-03 メルク エンド カムパニー インコーポレーテッドMerck & Company Incoporated Benzylamine derivatives and their use as thrombin inhibitors
US6528503B2 (en) 2000-12-18 2003-03-04 Merck & Co., Inc. Thrombin inhibitors
CA2436176A1 (en) 2001-02-09 2002-08-22 Philip E. Sanderson Thrombin inhibitors
AT317850T (en) 2001-05-30 2006-03-15 Novartis Pharma Gmbh 2 - ((n- (2-amino-3- (heteroaryl- or -aryl) propionyl) aminoacyl) amino) - alkylboronic acid derivatives
US7084134B2 (en) 2002-05-02 2006-08-01 Merk & Co., Inc. Thrombin inhibitors
US20050288253A1 (en) 2002-09-09 2005-12-29 Trigen Limited Boronic acid salts
WO2004022070A1 (en) 2002-09-09 2004-03-18 Trigen Limited Boronic acid salts useful in parenteral formulations for selective thrombin inhibition
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0315574A3 (en) * 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Renin inhibitors
DE3827340A1 (en) * 1988-08-12 1990-02-15 Hoechst Ag Use of (alpha) -aminoboronic acid derivatives for the prophylaxis and treatment of virus diseases
DE3840452A1 (en) * 1988-12-01 1990-06-07 Hoechst Ag (BETA) -amino-boronic acid DERIVATIVES

Also Published As

Publication number Publication date
HU912541D0 (en) 1992-01-28
ZA9106393B (en) 1993-04-28
FI913788A0 (en) 1991-08-09
IL99163A (en) 1996-01-19
MX9100628A (en) 1994-02-28
FI913788A (en) 1992-02-14
NZ239359A (en) 1993-09-27
JP2539965B2 (en) 1996-10-02
HUT59161A (en) 1992-04-28
IE912841A1 (en) 1992-02-26
AU8179291A (en) 1992-02-20
CA2048953A1 (en) 1992-02-14
TW275634B (en) 1996-05-11
EP0471651A3 (en) 1993-02-10
EP0471651A2 (en) 1992-02-19
KR920004416A (en) 1992-03-27
IL99163D0 (en) 1992-07-15
AU643312B2 (en) 1993-11-11
PT98638B (en) 1999-01-29
CS248491A3 (en) 1992-02-19
GB9017694D0 (en) 1990-09-26
FI913788D0 (en)
RU2075481C1 (en) 1997-03-20
JPH04330094A (en) 1992-11-18

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920225

FG3A Patent granted, date of granting

Effective date: 19981020

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20000430