PT98638A - METHOD FOR THE PREPARATION OF BORSOLINE DERIVATIVES - Google Patents

METHOD FOR THE PREPARATION OF BORSOLINE DERIVATIVES

Info

Publication number
PT98638A
PT98638A PT98638A PT9863891A PT98638A PT 98638 A PT98638 A PT 98638A PT 98638 A PT98638 A PT 98638A PT 9863891 A PT9863891 A PT 9863891A PT 98638 A PT98638 A PT 98638A
Authority
PT
Portugal
Prior art keywords
borsoline
derivatives
preparation
borsoline derivatives
Prior art date
Application number
PT98638A
Other languages
Portuguese (pt)
Other versions
PT98638B (en
Inventor
Rainer Metternich
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of PT98638A publication Critical patent/PT98638A/en
Publication of PT98638B publication Critical patent/PT98638B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT98638A 1990-08-13 1991-08-12 METHOD FOR THE PREPARATION OF BORSOLINE DERIVATIVES PT98638B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909017694A GB9017694D0 (en) 1990-08-13 1990-08-13 Improvements in or relating to organic chemistry

Publications (2)

Publication Number Publication Date
PT98638A true PT98638A (en) 1992-06-30
PT98638B PT98638B (en) 1999-01-29

Family

ID=10680563

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98638A PT98638B (en) 1990-08-13 1991-08-12 METHOD FOR THE PREPARATION OF BORSOLINE DERIVATIVES

Country Status (18)

Country Link
EP (1) EP0471651A3 (en)
JP (1) JP2539965B2 (en)
KR (1) KR920004416A (en)
AU (1) AU643312B2 (en)
CA (1) CA2048953A1 (en)
CS (1) CS248491A3 (en)
FI (1) FI913788A (en)
GB (1) GB9017694D0 (en)
HU (1) HUT59161A (en)
IE (1) IE912841A1 (en)
IL (1) IL99163A (en)
MX (1) MX9100628A (en)
MY (1) MY106529A (en)
NZ (1) NZ239359A (en)
PT (1) PT98638B (en)
RU (1) RU2075481C1 (en)
TW (1) TW275634B (en)
ZA (1) ZA916393B (en)

Families Citing this family (68)

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US6313096B1 (en) 1988-04-28 2001-11-06 Trigen Limited Inhibitors of trypsin-like enzymes
US5574014A (en) * 1988-04-28 1996-11-12 Thrombosis Research Institute Inhibitors of trypsin-like enzymes
US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
MX9206628A (en) * 1991-11-22 1993-05-01 Boehringer Ingelheim Pharma PROLINABORONATE ESTER AND METHOD FOR ITS PREPARATION.
WO1993021214A1 (en) * 1992-04-16 1993-10-28 Zeneca Limited Alpha-aminoboronic acid peptides and their use as elastase inhibitors
FR2701951B1 (en) * 1993-02-24 1995-06-09 Adir NOVEL PEPTIDE DERIVATIVES OF BORONIC ACID, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
EP0688336B1 (en) * 1993-03-03 1997-05-28 Novartis AG Peptide boronic acid derivatives having protease inhibiting activity
AU6448794A (en) * 1993-03-24 1994-10-11 Du Pont Merck Pharmaceutical Company, The Boronic acid and ester inhibitors of thrombin
US5563127A (en) * 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
SE9301916D0 (en) * 1993-06-03 1993-06-03 Ab Astra NEW PEPTIDES DERIVATIVES
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
US5783563A (en) * 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
IL111175A0 (en) * 1993-10-07 1994-12-29 Du Pont Merck Pharma Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them
WO1995009859A1 (en) * 1993-10-07 1995-04-13 The Du Pont Merck Pharmaceutical Company Boropeptide inhibitors of thrombin which contain a substituted pyrrolidine ring
IL111176A0 (en) * 1993-10-07 1994-12-29 Du Pont Merck Pharma Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them
US5462964A (en) * 1993-10-20 1995-10-31 The Du Pont Merck Pharmaceutical Company Dipeptide boronic acid inhibitors of trypsin-like enzymes
US6060462A (en) * 1993-10-20 2000-05-09 Dupont Pharmaceuticals Company Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
GB9401483D0 (en) * 1994-01-26 1994-03-23 Sandoz Ltd Organic compounds
US5693617A (en) * 1994-03-15 1997-12-02 Proscript, Inc. Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
DE4421052A1 (en) 1994-06-17 1995-12-21 Basf Ag New thrombin inhibitors, their production and use
FR2721611B1 (en) * 1994-06-22 1996-09-27 Adir New peptide derivatives of boronic acid, their process of preparation and the pharmaceutical compositions which contain them.
US5510369A (en) * 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
SE9404196D0 (en) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
SK104697A3 (en) * 1995-02-17 1998-11-04 Basf Ag Novel dipeptide amidines as thrombin inhibitors
US5629324A (en) * 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
EP0846682B9 (en) 1995-07-26 2003-05-14 Mitsubishi Chemical Corporation Penicillaminamide derivatives
GB9515489D0 (en) * 1995-07-28 1995-09-27 Sandoz Ltd Organic compounds
AR005245A1 (en) 1995-12-21 1999-04-28 Astrazeneca Ab THROMBIN INHIBITOR PRODROGES, A PHARMACEUTICAL FORMULATION THAT INCLUDES THEM, THE USE OF SUCH PRODROGES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND A PROCEDURE FOR ITS PREPARATION
FR2745288B1 (en) * 1996-02-27 1998-04-17 Adir NOVEL BORONIC ACID DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5965532A (en) * 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6004955A (en) * 1996-08-15 1999-12-21 Dupont Pharmaceuticals Company Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
AU743735B2 (en) * 1996-10-11 2002-02-07 Millennium Pharmaceuticals, Inc. Selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
WO1998016524A1 (en) * 1996-10-11 1998-04-23 Cor Therapeutics, Inc. HETEROCYCLIC DERIVATIVES AS FACTOR Xa INHIBITORS
AU743544B2 (en) * 1996-10-11 2002-01-31 Millennium Pharmaceuticals, Inc. Selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US5798377A (en) * 1996-10-21 1998-08-25 Merck & Co., Inc. Thrombin inhibitors
WO1998046626A1 (en) 1997-04-14 1998-10-22 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
AU747531B2 (en) 1997-04-14 2002-05-16 Millennium Pharmaceuticals, Inc. Selective factor Xa inhibitors
CA2285705A1 (en) * 1997-04-14 1998-10-22 Cor Therapeutics, Inc. Selective factor xa inhibitors
US6369063B1 (en) 1997-04-14 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
US6100234A (en) * 1997-05-07 2000-08-08 Tufts University Treatment of HIV
ES2239806T3 (en) 1997-06-19 2005-10-01 Bristol-Myers Squibb Pharma Company XA FACTOR INHIBITORS WITH A P1 NEUTRAL SPECIFICITY GROUP.
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
ES2285785T3 (en) 1997-09-29 2007-11-16 Point Therapeutics, Inc. STIMULATION OF IN VITRO HEMATOPOYETIC CELLS.
HUP0100082A3 (en) 1998-01-26 2001-12-28 Abbott Gmbh & Co Kg Thrombin inhibitor, peptide derivatives, pharmaceutical compositions comprising thereof and their use
JP2003504301A (en) 1998-04-01 2003-02-04 ブリストル−マイヤーズ スクイブ ファーマ カンパニー Integrin antagonist
AU770319C (en) 1998-05-04 2004-11-25 Point Therapeutics, Inc. Hematopoietic stimulation
AU765370B2 (en) 1998-06-05 2003-09-18 Point Therapeutics, Inc. Cyclic boroproline compounds
CA2320730A1 (en) 1998-12-23 2000-07-06 Renhua Li Thrombin or factor xa inhibitors
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
WO2002048157A2 (en) * 2000-12-13 2002-06-20 Bristol-Myers Squibb Pharma Company Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
JP2004516286A (en) 2000-12-18 2004-06-03 メルク エンド カムパニー インコーポレーテッド Benzylamine derivatives and their use as thrombin inhibitors
US6528503B2 (en) 2000-12-18 2003-03-04 Merck & Co., Inc. Thrombin inhibitors
US7144899B2 (en) 2001-02-09 2006-12-05 Merck & Co., Inc. Thrombin inhibitors
CN100415770C (en) 2001-05-30 2008-09-03 诺瓦提斯公司 2-{[N-(2-amino-3-(heteroaryl or aryl) propionyl)-aminoacyl]-amino}- alkylboronic acid derivatives
US7084134B2 (en) 2002-05-02 2006-08-01 Merk & Co., Inc. Thrombin inhibitors
MXPA05002661A (en) 2002-09-09 2005-08-19 Trigen Ltd Boronic acid salts ant their use in the treatment of thrombosis.
US7112572B2 (en) 2002-09-09 2006-09-26 Trigen Limited Multivalent metal salts of boronic acids
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
EP4257191A3 (en) 2016-06-21 2023-11-22 Orion Ophthalmology LLC Heterocyclic prolinamide derivatives
JP7164521B2 (en) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー carbocyclic prolinamide derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0315574A3 (en) * 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Renin inhibitors
DE3827340A1 (en) * 1988-08-12 1990-02-15 Hoechst Ag USE OF (ALPHA) -AMINOBORONIC ACID DERIVATIVES FOR THE PROPHYLAXIS AND TREATMENT OF VIRUS DISEASES
DE3840452A1 (en) * 1988-12-01 1990-06-07 Hoechst Ag (BETA) -amino-boronic acid DERIVATIVES

Also Published As

Publication number Publication date
AU8179291A (en) 1992-02-20
AU643312B2 (en) 1993-11-11
ZA916393B (en) 1993-04-28
KR920004416A (en) 1992-03-27
RU2075481C1 (en) 1997-03-20
FI913788A (en) 1992-02-14
FI913788A0 (en) 1991-08-09
EP0471651A3 (en) 1993-02-10
IL99163A (en) 1996-01-19
IL99163A0 (en) 1992-07-15
HUT59161A (en) 1992-04-28
JP2539965B2 (en) 1996-10-02
MX9100628A (en) 1994-02-28
CA2048953A1 (en) 1992-02-14
PT98638B (en) 1999-01-29
JPH04330094A (en) 1992-11-18
IE912841A1 (en) 1992-02-26
CS248491A3 (en) 1992-02-19
GB9017694D0 (en) 1990-09-26
NZ239359A (en) 1993-09-27
HU912541D0 (en) 1992-01-28
MY106529A (en) 1995-06-30
EP0471651A2 (en) 1992-02-19
TW275634B (en) 1996-05-11

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920225

FG3A Patent granted, date of granting

Effective date: 19981020

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20000430