PT944596E - Derivados de 1-acriloindolina e seu uso como prodrogas de agentes anticancerigenos - Google Patents

Derivados de 1-acriloindolina e seu uso como prodrogas de agentes anticancerigenos

Info

Publication number
PT944596E
PT944596E PT97948036T PT97948036T PT944596E PT 944596 E PT944596 E PT 944596E PT 97948036 T PT97948036 T PT 97948036T PT 97948036 T PT97948036 T PT 97948036T PT 944596 E PT944596 E PT 944596E
Authority
PT
Portugal
Prior art keywords
anticanancer
acrylindoline
derivatives
agent products
prodrug therapy
Prior art date
Application number
PT97948036T
Other languages
English (en)
Inventor
William Alexander Denny
Moana Tercel
Graham Atwell
Jared Milbank
Original Assignee
Auckland Uniservices Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auckland Uniservices Ltd filed Critical Auckland Uniservices Ltd
Publication of PT944596E publication Critical patent/PT944596E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
PT97948036T 1996-12-13 1997-12-12 Derivados de 1-acriloindolina e seu uso como prodrogas de agentes anticancerigenos PT944596E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9625913.0A GB9625913D0 (en) 1996-12-13 1996-12-13 Novel cyclopropylindoles and their seco precursors,and their use as prodrugs

Publications (1)

Publication Number Publication Date
PT944596E true PT944596E (pt) 2003-03-31

Family

ID=10804392

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97948036T PT944596E (pt) 1996-12-13 1997-12-12 Derivados de 1-acriloindolina e seu uso como prodrogas de agentes anticancerigenos

Country Status (12)

Country Link
EP (1) EP0944596B1 (pt)
JP (1) JP2001506623A (pt)
AT (1) ATE226194T1 (pt)
AU (1) AU728053B2 (pt)
CA (1) CA2272952A1 (pt)
DE (1) DE69716463T2 (pt)
DK (1) DK0944596T3 (pt)
ES (1) ES2186006T3 (pt)
GB (1) GB9625913D0 (pt)
NZ (1) NZ335841A (pt)
PT (1) PT944596E (pt)
WO (1) WO1998025898A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9909612D0 (en) * 1999-04-26 1999-06-23 Cancer Res Campaign Tech N-protected amines and their use as prodrugs
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
BRPI0921687A8 (pt) 2008-11-03 2022-11-08 Syntarga Bv Composto , conjugado , uso de um composto , composição farmacêutica, processo para preparar uma composição famacêutica , método para tratar um mamífero em necessidade do mesmo ,e, método para tratar ou prevenir um tumor em um mamífero.
JP5904944B2 (ja) * 2009-10-22 2016-04-20 フィブロテック セラピューティクス プロプライエタリー リミテッド 縮合環類似体の抗線維症剤
PL3056203T3 (pl) 2010-04-21 2018-06-29 Syntarga B.V. Koniugaty analogów CC-1065 i łączników dwufunkcyjnych
PT3092010T (pt) 2014-01-10 2018-09-28 Synthon Biopharmaceuticals Bv Método para purificação de conjugados anticorpo-fármaco ligados por cys

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8705477D0 (en) * 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
US5214065A (en) * 1990-06-11 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
US5258383A (en) * 1991-06-28 1993-11-02 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives

Also Published As

Publication number Publication date
CA2272952A1 (en) 1998-06-18
JP2001506623A (ja) 2001-05-22
EP0944596A1 (en) 1999-09-29
GB9625913D0 (en) 1997-01-29
ES2186006T3 (es) 2003-05-01
ATE226194T1 (de) 2002-11-15
DE69716463D1 (de) 2002-11-21
WO1998025898A1 (en) 1998-06-18
DE69716463T2 (de) 2003-06-05
NZ335841A (en) 2000-08-25
AU728053B2 (en) 2001-01-04
EP0944596B1 (en) 2002-10-16
AU5419298A (en) 1998-07-03
DK0944596T3 (da) 2002-12-16

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