PT94247A - Processo para a preparacao de uma composicao farmaceutica contendo 3'-azido-3'-desoxitimidina e n-butil-desoxinojirimicina e metodo para inibir hiv utilizando-a - Google Patents

Processo para a preparacao de uma composicao farmaceutica contendo 3'-azido-3'-desoxitimidina e n-butil-desoxinojirimicina e metodo para inibir hiv utilizando-a

Info

Publication number
PT94247A
PT94247A PT94247A PT9424790A PT94247A PT 94247 A PT94247 A PT 94247A PT 94247 A PT94247 A PT 94247A PT 9424790 A PT9424790 A PT 9424790A PT 94247 A PT94247 A PT 94247A
Authority
PT
Portugal
Prior art keywords
butyl
azido
hiv
pharmaceutical composition
deoxynojyrimycin
Prior art date
Application number
PT94247A
Other languages
English (en)
Other versions
PT94247B (pt
Inventor
Martin Stanley Hirsch
Victoria Anne Johnson
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of PT94247A publication Critical patent/PT94247A/pt
Publication of PT94247B publication Critical patent/PT94247B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT94247A 1989-06-02 1990-06-01 Processo para a preparacao de uma composicao farmaceutica contendo 3'-azido-3'-desoxitimidina e n-butil-desoxinojirimicina e metodo para inibir hiv utilizando-a PT94247B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/360,439 US5011829A (en) 1989-06-02 1989-06-02 Pharmaceutical composition and method of inhibiting virus

Publications (2)

Publication Number Publication Date
PT94247A true PT94247A (pt) 1991-02-08
PT94247B PT94247B (pt) 1997-05-28

Family

ID=23417957

Family Applications (1)

Application Number Title Priority Date Filing Date
PT94247A PT94247B (pt) 1989-06-02 1990-06-01 Processo para a preparacao de uma composicao farmaceutica contendo 3'-azido-3'-desoxitimidina e n-butil-desoxinojirimicina e metodo para inibir hiv utilizando-a

Country Status (10)

Country Link
US (1) US5011829A (pt)
EP (2) EP0437554B1 (pt)
JP (1) JPH04500220A (pt)
AT (1) ATE81979T1 (pt)
CA (1) CA2030803A1 (pt)
DE (1) DE69000434T2 (pt)
DK (1) DK0437554T3 (pt)
IE (1) IE64352B1 (pt)
PT (1) PT94247B (pt)
WO (1) WO1990014830A1 (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252587A (en) * 1990-04-27 1993-10-12 Merrell Dow Pharmaceuticals, Inc. N-derivatives of 1-deoxy nojirimycin
US5536732A (en) * 1990-04-27 1996-07-16 Merrell Pharmaceuticals Inc. N-derivatives of 1-deoxy nojirimycin
EP0547140A4 (en) * 1990-09-06 1993-10-13 The Australian National University Immunosuppressant composition
AU654152B2 (en) * 1990-09-06 1994-10-27 Australian National University, The Immunosuppressant composition
WO1992020344A1 (en) * 1991-05-16 1992-11-26 Glaxo Group Limited Antiviral combinations containing nucleoside analogs
US5331096A (en) * 1992-04-01 1994-07-19 G. D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US5206251A (en) * 1992-04-01 1993-04-27 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5216168A (en) * 1992-04-01 1993-06-01 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5258518A (en) * 1992-04-01 1993-11-02 G. D. Searle & Co. 2-substituted tertiary carbinol derivatives of deoxynojirimycin
US5268482A (en) * 1992-04-01 1993-12-07 G. D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US5342951A (en) * 1992-04-01 1994-08-30 G.D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
ES2113549T3 (es) * 1992-08-19 1998-05-01 Schering Corp Metodo para inhibir la replicacion de vih empleando il-4.
US6291657B1 (en) * 1993-05-13 2001-09-18 Monsanto Company Deoxygalactonojirimycin derivatives
US5798366A (en) * 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
US5399567A (en) * 1993-05-13 1995-03-21 Monsanto Company Method of treating cholera
US5639598A (en) * 1994-05-19 1997-06-17 The Trustees Of The University Of Pennsylvania Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US5780220A (en) * 1994-05-19 1998-07-14 Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting HIV replication
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
MY122499A (en) 1997-11-10 2006-04-29 Searle & Co Use of alkylated iminosugars to treat multidrug resistance
BR9907882A (pt) 1998-02-12 2000-10-17 Searle & Co Uso de compostos de 1,5-didesóxi-1,5-imino-d-glucitol n-substituìdos para o tratamento de infecções de vìrus de hepatite
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
WO2001008672A2 (en) 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
US6545021B1 (en) 1999-02-12 2003-04-08 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
US6569616B1 (en) * 1999-07-29 2003-05-27 Wisconsin Alumni Research Foundation Human cytomegalovirus glycoprotein O as a new drug target and subunit vaccine candidate
CN1422156A (zh) * 2000-02-14 2003-06-04 法马西亚公司 N－取代的－1,5－二脱氧－1,5－亚氨基－d－葡萄糖醇化合物在治疗肝炎病毒感染中的用途
US7884115B2 (en) * 2004-09-28 2011-02-08 Allergan, Inc. Methods and compositions for the treatment of pain and other neurological conditions
ES2572148T3 (es) 2005-05-17 2016-05-30 Amicus Therapeutics Inc Un método para el tratamiento de la enfermedad de Pompe usando 1-desoxinojirimicina y derivados
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
KR20230066482A (ko) 2012-03-07 2023-05-15 아미쿠스 세라퓨틱스, 인코포레이티드 폼페병의 치료를 위한 고농도 알파-글루코시다제 조성물
FI3201320T3 (fi) 2014-09-30 2024-01-08 Amicus Therapeutics Inc Erittäin tehokas hapan alfa-glukosidaasi parannetuilla hiilihydraateilla
KR102510941B1 (ko) 2015-12-30 2023-03-20 아미쿠스 세라퓨틱스, 인코포레이티드 폼페병 치료용의 강화된 산 알파-글루코시다제
KR20220145918A (ko) 2016-03-30 2022-10-31 아미쿠스 세라퓨틱스, 인코포레이티드 고 m6p 재조합 단백질의 선택 방법
CA3019128A1 (en) 2016-03-30 2017-10-05 Amicus Therapeutics, Inc. Formulations comprising recombinant acid alpha-glucosidase
CN109456254B (zh) * 2018-12-06 2020-06-30 江西农业大学 1-脱氧野尻霉素-羟基查尔酮杂合体衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
US4857511A (en) * 1985-09-17 1989-08-15 Burroughs Wellcome Co. Treatment of human viral infections
JPS63175354A (ja) * 1987-01-16 1988-07-19 Shin Kobe Electric Mach Co Ltd 電池用渦巻電極体の製造装置
EP0282618A1 (en) * 1987-03-18 1988-09-21 Vereniging Het Nederlands Kanker Instituut 1-Deoxynojirimycin as an anti-HIV therapeutic
US4849430A (en) * 1988-03-09 1989-07-18 Monsanto Company Method of inhibiting virus

Also Published As

Publication number Publication date
EP0437554A1 (en) 1991-07-24
CA2030803A1 (en) 1990-12-03
IE901973L (en) 1990-12-02
DE69000434T2 (de) 1993-05-27
DE69000434D1 (de) 1992-12-10
DK0437554T3 (da) 1992-12-07
WO1990014830A1 (en) 1990-12-13
JPH04500220A (ja) 1992-01-16
EP0401194A1 (en) 1990-12-05
ATE81979T1 (de) 1992-11-15
IE64352B1 (en) 1995-07-26
US5011829A (en) 1991-04-30
EP0437554B1 (en) 1992-11-04
PT94247B (pt) 1997-05-28

Similar Documents

Publication Publication Date Title
PT94247A (pt) Processo para a preparacao de uma composicao farmaceutica contendo 3'-azido-3'-desoxitimidina e n-butil-desoxinojirimicina e metodo para inibir hiv utilizando-a
PT87703A (pt) Processo para a preparacao de composicoes farmaceuticas contendo um derivado de 1,4-di-hidropiridina e um intensificador do fluxo transdermico
BR9404842A (pt) Compostos,processo para sua preparação e formulação farmacêutica
PT84785B (pt) Processo para a preparacao de composicoes farmceuticas que contem omeprazole para administracao por via oral
BR9407720A (pt) Composto composiçao farmacêutica e processo para a prevençao ou tratamento de pertubaçoes imunorreguladoras ou doenças que compreendem a administraçao do composto
EE03002B1 (et) 1,3-oksatiolaannukleosiidi analoogid, neid sisaldavad ravimpreparaadid ja nende valmistamise meetod
PT1110542E (pt) Dosagem diaria de metoprolol por via oral
PT88930A (pt) Processo para a preparacao de novos analogos de nucleosidos e de composicoes farmaceuticas que os contem
PT1040830E (pt) Medicamento para doencas neurodegenerativas
BR9503406A (pt) Formulaçoes farmacêuticas adaptadas para inhibir para perda de osso em um ser humano
BR9406509A (pt) Compostos processo sua preparação uso dos mesmos composições farmaceuticas e processo para profilaxia e para tratamento terapeutico de malária e doenças causadas por leishmania toxoplasma gondil pneumocy
MX12478A (es) Benzamidas n-sustituidas, procedimiento para su preparacion y composicion farmaceutica que las incluye
DE69109021D1 (de) Augentropfenarzneimittel.
ES2128519T3 (es) Nuevas pirido-tiadiazinas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
BR8800089A (pt) Processo para a preparacao de uma emulsao herbicida e composicao herbicida
BR8806217A (pt) Derivados de 2,2-difluorciclopropiletano,processo para sua preparacao,composicoes praguicidas e aplicacao
ES2172600T3 (es) Composicion farmaceutica que comprende lamotrigina.
ES2103440T3 (es) Nuevas amidas y sulfonamidas naftalenicas, procedimiento de preparacion y composiciones farmaceuticas que las contienen.
DK0443848T3 (da) Nyt antiulcermiddel
PT89266A (pt) Metodo para a inibicao de virus da imunodeficiencia humana utilizando um derivado n-n-butilo de desoxinojirimicina
BR9306207A (pt) Composiçao farmacéutica e processo para o tratamento de infecçao ou doença causada pelo vírus da hepatite b processo para a preparaçao da composiçao e uso de fiau ou de uma pró-droga ou metabolito do mesmo
PT90816A (pt) Processo para a preparacao de composicoes farmaceuticas contendo analogos de 2',5'-oligoadenilato
BR9407862A (pt) Composto de flavina flavina derivado de flavina ou uma mistura que compreende duas ou mais destas composiçao farmacêutica e processo para o tratamento por profilaxia ou terapia de doença causada por infecçao virótica
PT92345A (pt) Processo para a preparacao de composicoes farmaceuticas contendo derivados diterpenoides de labdano e derivados de pirimido(6,1-a)isoquinolina-4-ona
BR8801838A (pt) N-arilpirrolin-2,5-dionas,processo para sua preparacao,composicoes herbicidas,processo para combater ervas daninhas e para a preparacao de composicoes,derivados e compostos

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19970224

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19990831