PT93684A - Compsns. contg. biologically active peptide and antibiotic - which potentiate each other in treatment of infection and for use as preservative - Google Patents

Compsns. contg. biologically active peptide and antibiotic - which potentiate each other in treatment of infection and for use as preservative

Info

Publication number
PT93684A
PT93684A PT9368490A PT9368490A PT93684A PT 93684 A PT93684 A PT 93684A PT 9368490 A PT9368490 A PT 9368490A PT 9368490 A PT9368490 A PT 9368490A PT 93684 A PT93684 A PT 93684A
Authority
PT
Portugal
Prior art keywords
hydrophobic
basic
hydrophilic
peptide
antibiotic
Prior art date
Application number
PT9368490A
Other languages
Portuguese (pt)
Inventor
Michael Zasloff
Barry Berkowitz
Original Assignee
Magainin Science Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magainin Science Inc filed Critical Magainin Science Inc
Publication of PT93684A publication Critical patent/PT93684A/en

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Process comprises administering to a host at least one biologically active amphiphilic peptide (I), being an ion channel-forming peptide, and an antibiotic (II), in amts. effective to inhibit growth of a target cell. (II) is chosen from bacitracins, aminoglycoside antibiotics, penicillins, monobactams, hydrophobic antibiotics, 50-S ribosome inhibitors and antibiotics with a large lipid-like lactone ring. The compsn. is also claimed. typically a again in peptide including the following basic peptide structure (v): ---R11-R11-R12-R13-R14-R12-R11 R14-R11-R14-R11-R12-R11-R11- R11:-R14a-(15)12-R14a-R14----(v) R11=hydrophobic amino acid (aa); R12=basic hydrophilic aa; R13=hydrophobic, neutral hydrophilic or basic hydrophilic aa; R14=R14a=hydrophobic or basic or basic hydrophilic aa: R15=glutamic or aspartic acid; a hydrophobic or basic hydrophilic aa; R=0 or 1.
PT9368490A 1989-04-17 1990-04-06 Compsns. contg. biologically active peptide and antibiotic - which potentiate each other in treatment of infection and for use as preservative PT93684A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33929289A 1989-04-17 1989-04-17

Publications (1)

Publication Number Publication Date
PT93684A true PT93684A (en) 1990-11-20

Family

ID=23328345

Family Applications (1)

Application Number Title Priority Date Filing Date
PT9368490A PT93684A (en) 1989-04-17 1990-04-06 Compsns. contg. biologically active peptide and antibiotic - which potentiate each other in treatment of infection and for use as preservative

Country Status (2)

Country Link
PT (1) PT93684A (en)
ZA (1) ZA902525B (en)

Also Published As

Publication number Publication date
ZA902525B (en) 1991-05-29

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Legal Events

Date Code Title Description
FC3A Refusal

Effective date: 19960124