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Application filed by Janssen Pharmaceutica NvfiledCriticalJanssen Pharmaceutica Nv
Publication of PT92805ApublicationCriticalpatent/PT92805A/en
Publication of PT92805BpublicationCriticalpatent/PT92805B/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Plural Heterocyclic Compounds
(AREA)
Abstract
The invention relates to a process for the preparation of a compound of general formula I <IMAGE> its pharmaceutically acceptable acid addition salt and a stereochemically acceptable form thereof which comprises specifically: a) N-alkylating an intermediate of formula <IMAGE> with an alkylating reagent of formula L-W1 (III) in a solvent which is inert to the reaction in the presence of a base, or b) N-alkylating a compound of formula <IMAGE> with a reagent of formula R1-a-W1 in a solvent which is inert to the reaction and in the presence of a base, thus providing a compound of formula (I-a) <IMAGE>
PT9280590A1989-01-091990-01-08
PROCESS FOR THE PREPARATION OF 2-AMINO-PYRIMIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PT92805B
(en)
Process for producing n-/4-piperidyl/-substituted bicyclic condensed 2-imidazolyl-amine derivatives and pharmaceutical compositions containing them as active agents
Alkyl and cycloalkyl substituted 2-(2-(2-hydroxy-3-tert.-butylamino-propoxy)-5-acylaminophenyl)-1,3,4-oxadiazoles, their preparation and pharmaceutical preparations containing them