PT91207A - Process for the production of L-lysine by the fermentation of a mutant strain of Corynebacterium glutamicum and isolation of the said strain - Google Patents
Process for the production of L-lysine by the fermentation of a mutant strain of Corynebacterium glutamicum and isolation of the said strainInfo
- Publication number
- PT91207A PT91207A PT9120789A PT9120789A PT91207A PT 91207 A PT91207 A PT 91207A PT 9120789 A PT9120789 A PT 9120789A PT 9120789 A PT9120789 A PT 9120789A PT 91207 A PT91207 A PT 91207A
- Authority
- PT
- Portugal
- Prior art keywords
- corynebacterium glutamicum
- lysine
- lnbt
- fermentation
- strain
- Prior art date
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
This invention relates to an improved process for the production of L-lysine by the fermentation of the mutant strain Corynebacterium glutamicum LNBT-221 under aerobic conditions at a temperature between 30 and 38 degree C and a pH of 6-8. This new mutant has the ability to utilize an extensive range of substrates, including carbohydrates and acetate. The fermentation means may contain complex organic sources of carbon and/or nitrogen as well as closely specified chemically synthesized means. The L-lysine which accumulates outside the cells in the fermentation medium can be recovered therefrom using appropriate techniques such as e.g. the use of ion exchange resins. Its scope also includes a process for the isolation of a new mutant strain of Corynebacterium glutamicum LNBT-221 which was selected after mutagenesis of the parent strain, Corynebacterium glutamicum LNBT-20, which was in turn derived from Corynebacterium glutamicum ATCC 21513, with N-methyl-N'-nitro-N-nitrosoguanidine. The mutant strain LNBT-221 was selected on the basis of its hypersensitivity to monofluoroacetate and is capable of overproducing L-lysine in quantities greater than those produced by the strains from which it was derived.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT9120789A PT91207B (en) | 1989-07-18 | 1989-07-18 | Process for the production of L-Lysine by fermentation of a strain of corynebacterium glutamicum and isolation of the strain STIRPE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT9120789A PT91207B (en) | 1989-07-18 | 1989-07-18 | Process for the production of L-Lysine by fermentation of a strain of corynebacterium glutamicum and isolation of the strain STIRPE |
Publications (2)
Publication Number | Publication Date |
---|---|
PT91207A true PT91207A (en) | 1990-07-31 |
PT91207B PT91207B (en) | 1995-05-04 |
Family
ID=20084531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT9120789A PT91207B (en) | 1989-07-18 | 1989-07-18 | Process for the production of L-Lysine by fermentation of a strain of corynebacterium glutamicum and isolation of the strain STIRPE |
Country Status (1)
Country | Link |
---|---|
PT (1) | PT91207B (en) |
-
1989
- 1989-07-18 PT PT9120789A patent/PT91207B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT91207B (en) | 1995-05-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19941003 |
|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19960430 |