PT90300A - Processo para a preparacao de derivados de 5-{2-{n-{2-amino-2-oxo-etil}-metilamino}-etil}-3-hidroxi-2-(4-metoxi-fenil)-2,3-dihidro-5h-1,5-benzotiazepina-4-ona - Google Patents

Processo para a preparacao de derivados de 5-{2-{n-{2-amino-2-oxo-etil}-metilamino}-etil}-3-hidroxi-2-(4-metoxi-fenil)-2,3-dihidro-5h-1,5-benzotiazepina-4-ona

Info

Publication number
PT90300A
PT90300A PT90300A PT9030089A PT90300A PT 90300 A PT90300 A PT 90300A PT 90300 A PT90300 A PT 90300A PT 9030089 A PT9030089 A PT 9030089A PT 90300 A PT90300 A PT 90300A
Authority
PT
Portugal
Prior art keywords
benzotiazepine
eetyl
ona
methylamino
dihydro
Prior art date
Application number
PT90300A
Other languages
English (en)
Inventor
Jean-Claude Muller
Colombe Denys
Alistair Lochead
Andre Dumas
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of PT90300A publication Critical patent/PT90300A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT90300A 1988-04-19 1989-04-18 Processo para a preparacao de derivados de 5-{2-{n-{2-amino-2-oxo-etil}-metilamino}-etil}-3-hidroxi-2-(4-metoxi-fenil)-2,3-dihidro-5h-1,5-benzotiazepina-4-ona PT90300A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8805131A FR2630109B1 (fr) 1988-04-19 1988-04-19 Derives de ((n-(amino-2 oxo-2 ethyl)methylamino)-2 ethyl)-5 hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
PT90300A true PT90300A (pt) 1989-11-10

Family

ID=9365423

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90300A PT90300A (pt) 1988-04-19 1989-04-18 Processo para a preparacao de derivados de 5-{2-{n-{2-amino-2-oxo-etil}-metilamino}-etil}-3-hidroxi-2-(4-metoxi-fenil)-2,3-dihidro-5h-1,5-benzotiazepina-4-ona

Country Status (14)

Country Link
US (1) US4914092A (pt)
EP (1) EP0338892A1 (pt)
JP (1) JPH01311073A (pt)
KR (1) KR890016028A (pt)
AU (1) AU616003B2 (pt)
DK (1) DK185589A (pt)
FI (1) FI891840A (pt)
FR (1) FR2630109B1 (pt)
HU (1) HU201320B (pt)
IL (1) IL90000A0 (pt)
NO (1) NO891574L (pt)
NZ (1) NZ228789A (pt)
PT (1) PT90300A (pt)
ZA (1) ZA892841B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2624117B1 (fr) * 1987-12-08 1991-02-22 Synthelabo Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique
FR2653122B1 (fr) * 1989-10-17 1994-04-15 Synthelabo Derives de 5-[2-[[2-amino-2-oxoethyl]methylamino]ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepine-4-one, leur preparation et leur application en therapeutique.
FR2670785B1 (fr) * 1990-12-20 1993-07-09 Synthelabo Derives de (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique.
EP0702009B1 (en) * 1994-09-16 1998-07-01 Orion Corporation Fermion Method for the preparation of pharmaceutically active benzothiazepine derivatives
EP1175209A2 (en) * 1999-04-30 2002-01-30 Merab Lomia Use of antiepileptics for treating respiratory disorders, in particular asthmatic disorders
EP1196386A2 (en) 1999-07-06 2002-04-17 Vertex Pharmaceuticals Incorporated N-substituted glycine derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH538492A (de) * 1970-10-07 1973-06-30 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
FR2597097B1 (fr) * 1986-04-15 1988-12-02 Synthelabo Derives de benzothiazepine-1, 5, leur preparation et leur application en therapeutique
DE3771143D1 (de) * 1986-08-20 1991-08-08 Mcneilab Inc Benzothiazepin-vasodilatoren mit aralkylsubstitution.
US4729994A (en) * 1986-08-20 1988-03-08 Mcneilab, Inc. Benzothiazepine vasodilators having aralkyl substitution
FR2624117B1 (fr) * 1987-12-08 1991-02-22 Synthelabo Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
HU201320B (en) 1990-10-28
NZ228789A (en) 1990-07-26
US4914092A (en) 1990-04-03
NO891574D0 (no) 1989-04-18
AU616003B2 (en) 1991-10-17
JPH01311073A (ja) 1989-12-15
AU3315289A (en) 1989-10-26
FI891840A0 (fi) 1989-04-18
FR2630109A1 (fr) 1989-10-20
KR890016028A (ko) 1989-11-28
FI891840A (fi) 1989-10-20
EP0338892A1 (fr) 1989-10-25
NO891574L (no) 1989-10-20
IL90000A0 (en) 1989-12-15
FR2630109B1 (fr) 1991-11-29
ZA892841B (en) 1989-12-27
DK185589D0 (da) 1989-04-18
HUT51608A (en) 1990-05-28
DK185589A (da) 1989-10-20

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Legal Events

Date Code Title Description
FC3A Refusal

Effective date: 19940525