PT89537A - Angiotensin converting enzyme inhibitors - e.g. new octyl 2-alanyl-2-aza-bi:cyclooctane-3-carboxylate derivs., used as psychotropic agents
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Angiotensin converting enzyme inhibitors - e.g. new octyl 2-alanyl-2-aza-bi:cyclooctane-3-carboxylate derivs., used as psychotropic agents
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Priority claimed from DE19883802302external-prioritypatent/DE3802302A1/en
Application filed by Hoechst AgfiledCriticalHoechst Ag
Publication of PT89537ApublicationCriticalpatent/PT89537A/en
Publication of PT89537BpublicationCriticalpatent/PT89537B/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Peptides Or Proteins
(AREA)
Abstract
(A) n-Octyl 2-alanyl-2-azabicyclo (3,3,0)octane-3- carboxylate derivs. of formula (Ia), in which all five chiral C atoms are in the S configuration, and their salts are new: R'2 = H or Et; R'3 = n-octyl. (B) Intermediates of formula (IX) and (X) in all-S isomer form are also new (see 'Preparation'). (C) ACE inhibitors (I) are used to prepare medicaments with psychotropic, esp. anxiolytic, activity. Pref (I) have min effective doses of 0.1-30 mg/kg in the 'lick-shock' and 'Geller-Seifter' conflict tests.
PT8953789A1988-01-271989-01-26
PROCESS FOR THE PREPARATION OF SUBSTITUTED DERIVATIVES OF N-OCTILO AZABICYCLO- {3.3.0} OCTANO-3-CARBOXYLATE WITH PSYCHOTROPIC ACTION
PT89537B
(en)
DERIVATIVES OF 8- (1-AMINOCYCLOALKYL) 1,3-DIALKYLXANTINE, PREPARATION PROCEDURE AND THEIR PHARMACEUTICAL COMPOSITIONS ANTIDEPRESSANTS, NOOTROPICS AND PSYCHOSTIMULANTS
Use of a compound, process for the treatment of a vascular headache condition, and, pharmaceutical composition suitable for use in the treatment of a vascular headache condition.
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