PT89537A - Angiotensin converting enzyme inhibitors - e.g. new octyl 2-alanyl-2-aza-bi:cyclooctane-3-carboxylate derivs., used as psychotropic agents - Google Patents

Angiotensin converting enzyme inhibitors - e.g. new octyl 2-alanyl-2-aza-bi:cyclooctane-3-carboxylate derivs., used as psychotropic agents

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Publication number
PT89537A
PT89537A PT8953789A PT8953789A PT89537A PT 89537 A PT89537 A PT 89537A PT 8953789 A PT8953789 A PT 8953789A PT 8953789 A PT8953789 A PT 8953789A PT 89537 A PT89537 A PT 89537A
Authority
PT
Portugal
Prior art keywords
derivs
alanyl
carboxylate
cyclooctane
aza
Prior art date
Application number
PT8953789A
Other languages
Portuguese (pt)
Other versions
PT89537B (en
Inventor
Rainer Henning
Franz Hock
Jens Stechl
Patricia Usinger
Hansjorg Urbach
Wolfgang Ruger
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19883802302 external-priority patent/DE3802302A1/en
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PT89537A publication Critical patent/PT89537A/en
Publication of PT89537B publication Critical patent/PT89537B/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

(A) n-Octyl 2-alanyl-2-azabicyclo (3,3,0)octane-3- carboxylate derivs. of formula (Ia), in which all five chiral C atoms are in the S configuration, and their salts are new: R'2 = H or Et; R'3 = n-octyl. (B) Intermediates of formula (IX) and (X) in all-S isomer form are also new (see 'Preparation'). (C) ACE inhibitors (I) are used to prepare medicaments with psychotropic, esp. anxiolytic, activity. Pref (I) have min effective doses of 0.1-30 mg/kg in the 'lick-shock' and 'Geller-Seifter' conflict tests.
PT8953789A 1988-01-27 1989-01-26 PROCESS FOR THE PREPARATION OF SUBSTITUTED DERIVATIVES OF N-OCTILO AZABICYCLO- {3.3.0} OCTANO-3-CARBOXYLATE WITH PSYCHOTROPIC ACTION PT89537B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19883802302 DE3802302A1 (en) 1987-01-28 1988-01-27 SHAPED COUPLING
DE3802760 1988-01-30
DE3813819 1988-04-22

Publications (2)

Publication Number Publication Date
PT89537A true PT89537A (en) 1989-10-04
PT89537B PT89537B (en) 1994-05-31

Family

ID=27197110

Family Applications (1)

Application Number Title Priority Date Filing Date
PT8953789A PT89537B (en) 1988-01-27 1989-01-26 PROCESS FOR THE PREPARATION OF SUBSTITUTED DERIVATIVES OF N-OCTILO AZABICYCLO- {3.3.0} OCTANO-3-CARBOXYLATE WITH PSYCHOTROPIC ACTION

Country Status (1)

Country Link
PT (1) PT89537B (en)

Also Published As

Publication number Publication date
PT89537B (en) 1994-05-31

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19931112

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19950531