PT84584A - A process for the preparation of forskolin from 9-deoxy-forskolin and intermediates used therein - Google Patents

A process for the preparation of forskolin from 9-deoxy-forskolin and intermediates used therein

Info

Publication number
PT84584A
PT84584A PT84584A PT8458487A PT84584A PT 84584 A PT84584 A PT 84584A PT 84584 A PT84584 A PT 84584A PT 8458487 A PT8458487 A PT 8458487A PT 84584 A PT84584 A PT 84584A
Authority
PT
Portugal
Prior art keywords
beta
alpha
epoxy
forskolin
tetrahydroxylabd
Prior art date
Application number
PT84584A
Other languages
English (en)
Other versions
PT84584B (pt
Inventor
Nicholas J Hrib
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of PT84584A publication Critical patent/PT84584A/pt
Publication of PT84584B publication Critical patent/PT84584B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Excavating Of Shafts Or Tunnels (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Toys (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Shaping Of Tube Ends By Bending Or Straightening (AREA)
PT84584A 1986-03-31 1987-03-30 Processo para a preparacao de forescolina a partir de 9-deoxi-forescolina e dos intermediarios utilizados PT84584B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/846,550 US4734513A (en) 1986-03-31 1986-03-31 Method of synthesizing forskolin from 9-deoxyforskolin

Publications (2)

Publication Number Publication Date
PT84584A true PT84584A (en) 1987-04-01
PT84584B PT84584B (pt) 1989-11-30

Family

ID=25298260

Family Applications (1)

Application Number Title Priority Date Filing Date
PT84584A PT84584B (pt) 1986-03-31 1987-03-30 Processo para a preparacao de forescolina a partir de 9-deoxi-forescolina e dos intermediarios utilizados

Country Status (13)

Country Link
US (1) US4734513A (pt)
EP (1) EP0243646B1 (pt)
JP (1) JPS62249981A (pt)
KR (1) KR900007626B1 (pt)
AT (1) ATE45353T1 (pt)
AU (1) AU585143B2 (pt)
DE (1) DE3760422D1 (pt)
DK (1) DK159987A (pt)
ES (1) ES2010511B3 (pt)
GR (1) GR3000203T3 (pt)
IL (1) IL82047A (pt)
PT (1) PT84584B (pt)
ZA (1) ZA872266B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008407A (en) * 1986-03-31 1991-04-16 Hoechst-Roussel Pharmaceuticals Inc. Method of synthesizing forskolin from 9-deoxyforskolin
US4978678A (en) * 1986-11-20 1990-12-18 Hoechst-Roussel Pharmaceuticals Inc. 12-halogenated forskolin derivatives
US5070209A (en) * 1986-11-20 1991-12-03 Hoechst Roussel Pharmaceuticals Inc. 12-halogenated forskolin derivatives
US5023344A (en) * 1986-11-20 1991-06-11 Hoechst-Roussel Pharmaceuticals Incorporated 12-halogenated forskolin derivatives
US4999351A (en) * 1989-01-11 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 7-aryl and heteroaryl ethers of desacetylforskolin
JP3557095B2 (ja) * 1998-04-20 2004-08-25 高砂香料工業株式会社 メラニン産生抑制剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2654796A1 (de) * 1976-12-03 1978-06-08 Hoechst Ag Polyoxygenierte labdan-derivate
US4517200A (en) * 1982-12-27 1985-05-14 Schering-Plough Corporation Method for treating allergic reactions with forskolin
US4564626A (en) * 1983-04-01 1986-01-14 Schering Corporation Methods of inducing bronchodilation
DE3407514A1 (de) * 1984-03-01 1985-09-26 Hoechst Ag, 6230 Frankfurt Verwendung von polyoxygenierten labdanderivaten zur behandlung von konstriktionen der atemwege
DE3581725D1 (de) * 1984-12-14 1991-03-14 Hoechst Roussel Pharma Aminoacyllabdane, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
US4639443A (en) * 1985-03-01 1987-01-27 Hoechst-Roussel Pharmaceuticals Inc. Labdane compounds, pharmaceutical compositions and use

Also Published As

Publication number Publication date
DK159987D0 (da) 1987-03-30
GR3000203T3 (en) 1990-12-31
IL82047A (en) 1992-02-16
EP0243646A1 (en) 1987-11-04
DK159987A (da) 1987-10-01
KR900007626B1 (ko) 1990-10-17
US4734513A (en) 1988-03-29
ATE45353T1 (de) 1989-08-15
IL82047A0 (en) 1987-10-20
PT84584B (pt) 1989-11-30
EP0243646B1 (en) 1989-08-09
KR870008908A (ko) 1987-10-21
AU7076587A (en) 1987-10-08
DE3760422D1 (en) 1989-09-14
JPS62249981A (ja) 1987-10-30
ZA872266B (en) 1987-11-25
AU585143B2 (en) 1989-06-08
ES2010511B3 (es) 1989-11-16

Similar Documents

Publication Publication Date Title
DE3760422D1 (en) A process for the preparation of forskolin from 9-deoxy-forskolin and intermediates used therein
CA1273957C (pt)
NO854596L (no) Fremgangsmaate for fremstilling av vinylesterharpikser som inneholder triazin- eller baade triazin- og oksazolin-grupper
EP0057045A3 (en) Derivatives of 5-hydroxy-tetrahydro-2-furanone
ATE82569T1 (de) Herstellung von chinolincarbonsaeuren.
UA13378A (uk) СПОСІБ ОДЕРЖАHHЯ ПОХІДHИХ 14, 17-beta-ЕТАHО-14-beta-ЕСТРАТРІЄHУ
IT8248374A0 (it) Procedimento di fermentazione a stadio unico per la preparazione di acido 9-idrossi-3-osso-4,17(20)pregnadien-20-carbossilico, utile come intermedio per la produzionedi steroidi
PT69814A (en) Process for preparing carbalole derivatives
ES483284A1 (es) Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
JPS6490182A (en) Production of hydroxy-macrocyclic lactone
DE3260782D1 (en) Method for the preparation of 1,1'-diacetals
YU198888A (en) Process for obtaining ether's polycyclical antibiotic
ATE127782T1 (de) Herstellung von alkansulfonamiden.
DE3572965D1 (en) Process for the production of optically active quinone derivatives
ATE12391T1 (de) Verfahren zur herstellung von tetronsaeure.
PL252195A1 (en) Method of obtaining terephtalic acid from p-xylene and methanol through dimethyl terephtalic ester as intermediate product
HUT44570A (en) Process for preparing cyclic propylene ester derivatives of dihydropyridine-5-phosphonic acid
HUT38891A (en) Process for preparing halogenated 3,3-dimethyl-5-hexen-2-one-derivatives
AU590659B2 (en) Process for producing l-amino acids or 5'-inosinic acid by fermentation
JPS57209300A (en) Novel steroid derivative and its preparation
JPS6456639A (en) Production of acetylacetone
EP0234350A3 (en) Process for producing imidazolylthiophenaldehydes
ZA869400B (en) A process for the preparation of 7alpha-acetylthiosteroids
BG50275A3 (en) Method for the preparation of derivatives of 1- benzyl- indazol- 3- il
JPS57192359A (en) Optical resolution of 3-benzoyl-2-methylindole derivative

Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19931130