PT83229A - Process for the preparation of cephalosporin intermediates - Google Patents
Process for the preparation of cephalosporin intermediatesInfo
- Publication number
- PT83229A PT83229A PT8322986A PT8322986A PT83229A PT 83229 A PT83229 A PT 83229A PT 8322986 A PT8322986 A PT 8322986A PT 8322986 A PT8322986 A PT 8322986A PT 83229 A PT83229 A PT 83229A
- Authority
- PT
- Portugal
- Prior art keywords
- formula
- trichlorotrifluoroethane
- prepn
- ch2cl2
- freon
- Prior art date
Links
Landscapes
- Cephalosporin Compounds (AREA)
- Catalysts (AREA)
Abstract
Prepn. of stable, crystalline cephalosporin cpds. of formula (I), free of the delta 2 isomer, comprises treating a cpd. of formula (II) where X = HCl or HI; Z = COOH and Q = Nu; or Z = COO(-) and Q = Nu(+); Q' = Nu or Nu(+)I(-); n = 0 or 1; Nu = N-heterocycle linked via S, of formula (a), (b), (c), (d) or (e); Nu(+) = N-contg. heterocycle linked through quat. N ring atom of formula (f), (g), (h) or (i); in CH2Cl2 when n = 1, or in CH2Cl2, 1,1,2-trichlorotrifluoroethane (freon TF) or 1,1,1-trichlorotrifluoroethane when n = 0, with lower alkanol (MeOH) to remove silyl gps., followed by acidification with HCl or HI, provided that when Nu(+) = 1-methyl-1-pyrrolidinio (h) and n = 0, the reaction is in Freon TF or 1,1,1-trichlorotrifluoroethane. Processes for (I) are also claimed: (i) including prepn. of the starting materials (II); and (ii) for prepn. of (I; Q = (h)) in an alternative embodiment.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76756185A | 1985-08-20 | 1985-08-20 | |
US06/882,107 US4714760A (en) | 1985-08-20 | 1986-07-11 | Cephalosporin intermediates |
PCT/US1986/001637 WO1987001116A1 (en) | 1985-08-20 | 1986-08-12 | Process for preparing cephalosporin intermediates |
Publications (2)
Publication Number | Publication Date |
---|---|
PT83229A true PT83229A (en) | 1986-09-01 |
PT83229B PT83229B (en) | 1989-05-12 |
Family
ID=27375255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT83229A PT83229B (en) | 1985-08-20 | 1986-08-20 | PROCESS FOR THE PREPARATION OF INTERMEDIATE COMPOUNDS OF CEFALOSPORINA |
Country Status (5)
Country | Link |
---|---|
DE (1) | DE3688067T2 (en) |
ES (1) | ES2001101A6 (en) |
GR (1) | GR862161B (en) |
PT (1) | PT83229B (en) |
YU (1) | YU44792B (en) |
-
1986
- 1986-08-12 DE DE19863688067 patent/DE3688067T2/en not_active Expired - Lifetime
- 1986-08-19 ES ES8601189A patent/ES2001101A6/en not_active Expired
- 1986-08-20 GR GR862161A patent/GR862161B/en unknown
- 1986-08-20 PT PT83229A patent/PT83229B/en unknown
- 1986-08-20 YU YU145986A patent/YU44792B/en unknown
Also Published As
Publication number | Publication date |
---|---|
GR862161B (en) | 1986-12-24 |
YU44792B (en) | 1991-02-28 |
DE3688067D1 (en) | 1993-04-22 |
YU145986A (en) | 1988-02-29 |
DE3688067T2 (en) | 1993-07-01 |
PT83229B (en) | 1989-05-12 |
ES2001101A6 (en) | 1988-04-16 |
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