PT83229A - Process for the preparation of cephalosporin intermediates - Google Patents

Process for the preparation of cephalosporin intermediates

Info

Publication number
PT83229A
PT83229A PT8322986A PT8322986A PT83229A PT 83229 A PT83229 A PT 83229A PT 8322986 A PT8322986 A PT 8322986A PT 8322986 A PT8322986 A PT 8322986A PT 83229 A PT83229 A PT 83229A
Authority
PT
Portugal
Prior art keywords
formula
trichlorotrifluoroethane
prepn
ch2cl2
freon
Prior art date
Application number
PT8322986A
Other languages
Portuguese (pt)
Other versions
PT83229B (en
Inventor
Steven P Brundidge
Paul R Brodfueher
Chet Sapino Jr
Kun Mao Shin
Donald G Walker
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/882,107 external-priority patent/US4714760A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of PT83229A publication Critical patent/PT83229A/en
Publication of PT83229B publication Critical patent/PT83229B/en

Links

Landscapes

  • Cephalosporin Compounds (AREA)
  • Catalysts (AREA)

Abstract

Prepn. of stable, crystalline cephalosporin cpds. of formula (I), free of the delta 2 isomer, comprises treating a cpd. of formula (II) where X = HCl or HI; Z = COOH and Q = Nu; or Z = COO(-) and Q = Nu(+); Q' = Nu or Nu(+)I(-); n = 0 or 1; Nu = N-heterocycle linked via S, of formula (a), (b), (c), (d) or (e); Nu(+) = N-contg. heterocycle linked through quat. N ring atom of formula (f), (g), (h) or (i); in CH2Cl2 when n = 1, or in CH2Cl2, 1,1,2-trichlorotrifluoroethane (freon TF) or 1,1,1-trichlorotrifluoroethane when n = 0, with lower alkanol (MeOH) to remove silyl gps., followed by acidification with HCl or HI, provided that when Nu(+) = 1-methyl-1-pyrrolidinio (h) and n = 0, the reaction is in Freon TF or 1,1,1-trichlorotrifluoroethane. Processes for (I) are also claimed: (i) including prepn. of the starting materials (II); and (ii) for prepn. of (I; Q = (h)) in an alternative embodiment.
PT83229A 1985-08-20 1986-08-20 PROCESS FOR THE PREPARATION OF INTERMEDIATE COMPOUNDS OF CEFALOSPORINA PT83229B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76756185A 1985-08-20 1985-08-20
US06/882,107 US4714760A (en) 1985-08-20 1986-07-11 Cephalosporin intermediates
PCT/US1986/001637 WO1987001116A1 (en) 1985-08-20 1986-08-12 Process for preparing cephalosporin intermediates

Publications (2)

Publication Number Publication Date
PT83229A true PT83229A (en) 1986-09-01
PT83229B PT83229B (en) 1989-05-12

Family

ID=27375255

Family Applications (1)

Application Number Title Priority Date Filing Date
PT83229A PT83229B (en) 1985-08-20 1986-08-20 PROCESS FOR THE PREPARATION OF INTERMEDIATE COMPOUNDS OF CEFALOSPORINA

Country Status (5)

Country Link
DE (1) DE3688067T2 (en)
ES (1) ES2001101A6 (en)
GR (1) GR862161B (en)
PT (1) PT83229B (en)
YU (1) YU44792B (en)

Also Published As

Publication number Publication date
GR862161B (en) 1986-12-24
YU44792B (en) 1991-02-28
DE3688067D1 (en) 1993-04-22
YU145986A (en) 1988-02-29
DE3688067T2 (en) 1993-07-01
PT83229B (en) 1989-05-12
ES2001101A6 (en) 1988-04-16

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