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Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
hydrochloride of formula (I) is prepd. from 4'-epi-N-trifluoroacetyl daunorubicin dissolved in anhydrous methylene chloride, by reaction in presence of pyridine, with trifluoromethyl sulphonic anhydride to give 4'-epi 4'-trifluoromethyl sulphonyl oxy N-trifluoroacetyl daunorubicin. This is treated with tetrabutyl ammonium iodide to obtain 4'-deoxy 4'-iodo N-trifluoroacetyl daunorubicin, from which the halogen is eliminated reductively with tributyl tin hydride to give 4'-de oxy daunorubicin. Treatment with bromine gives the 14-bromo deriv., which is then hydrolysed with an aq. soln. of sodium formate to give (I), which is isolated as the hydrochloride.
PT7861684A1984-05-181984-05-18Improved process for the preparation of 4'-deoxydoxorubicin
PT78616B
(en)
Fluorocarbohydrates in synthesis. An efficient synthesis of 1-(2-deoxy-2-fluoro-. beta.-D-arabinofuranosyl)-5-iodouracil (. beta.-FIAU) and 1-(2-deoxy-2-fluoro-. beta.-D-arabinofuranosyl) thymine (. beta.-FMAU)
Process for recovering rhodium from water solutions, which contains complex rhodium compounds, which is used as a catalyzer at olephine hydroformalizing*