PT73546A - Process for preparing 2-penem compounds - Google Patents

Process for preparing 2-penem compounds

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Publication number
PT73546A
PT73546A PT7354681A PT7354681A PT73546A PT 73546 A PT73546 A PT 73546A PT 7354681 A PT7354681 A PT 7354681A PT 7354681 A PT7354681 A PT 7354681A PT 73546 A PT73546 A PT 73546A
Authority
PT
Portugal
Prior art keywords
alkyl
aralkyl
aryl
alkylamino
quat
Prior art date
Application number
PT7354681A
Other languages
Portuguese (pt)
Other versions
PT73546B (en
Inventor
Adriano Afonso
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to PT7354681A priority Critical patent/PT73546B/en
Publication of PT73546A publication Critical patent/PT73546A/en
Publication of PT73546B publication Critical patent/PT73546B/en

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Abstract

2-(Substd-alkylthio)-2- penem-3-carboxylic acids, salts and esters of formula (I) are new. In (I) n is 0-4; R is H, alkali metal, quat. ammonium cation or a metabolisable ester gp.; R1 and R2 are H or 1-6C alkyl; R4 is H, 1-6C alkyl or R5CH(OH); R5 is H, 1-6C alkyl, aryl, aralkyl, heteroaryl or heteroaralkyl, R6 is NH2, 1-6C alkylamino, an alpha-amino acid residue bonded through the alpha-N atom or OR8; R8 is H, 1-6C alkyl, allyl, aryl, aralkyl, alkali metal, quat. ammonium cation or a metabolisable ester gp.; R7 is H, 1-6C alkyl, (1-6C)alkoxycarbonyl, aryl, aralkyl, aralkoxycarbonyl, arylsulphonyl or acyl; or NHR7 is N(CR9R10); either R9 is aryl and R10 is H, 1-6C alkyl or aralkyl; or R9 is H, NH2, mono- or di-(1-6C)-alkylamino and R10 is NH2, mono- or di-(1-6C)-alkylamino, 1-6C alkyl, aryl, aralkyl or (1-6C) alkoxycarbonyl. When R7 is H, then 1,3-dicarbonyl adducts at the 2'-amino gp. may be formed. Cpds. (I) are broad-spectrum antibacterials and are inhibitors of bacterial beta-lactamases and so are effective against normally resistant bacterial strains. Dose is 0.1-5g daily.
PT7354681A 1981-08-20 1981-08-20 Process for preparing 2-penem compounds PT73546B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PT7354681A PT73546B (en) 1981-08-20 1981-08-20 Process for preparing 2-penem compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT7354681A PT73546B (en) 1981-08-20 1981-08-20 Process for preparing 2-penem compounds

Publications (2)

Publication Number Publication Date
PT73546A true PT73546A (en) 1981-09-01
PT73546B PT73546B (en) 1982-11-03

Family

ID=20082962

Family Applications (1)

Application Number Title Priority Date Filing Date
PT7354681A PT73546B (en) 1981-08-20 1981-08-20 Process for preparing 2-penem compounds

Country Status (1)

Country Link
PT (1) PT73546B (en)

Also Published As

Publication number Publication date
PT73546B (en) 1982-11-03

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