PT72772B - Process for preparing 4-alkylsubstituted-3-hidroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase - Google Patents

Process for preparing 4-alkylsubstituted-3-hidroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

Info

Publication number
PT72772B
PT72772B PT72772A PT7277281A PT72772B PT 72772 B PT72772 B PT 72772B PT 72772 A PT72772 A PT 72772A PT 7277281 A PT7277281 A PT 7277281A PT 72772 B PT72772 B PT 72772B
Authority
PT
Portugal
Prior art keywords
hidroxy
alkylsubstituted
pyrroline
preparing
glycolic acid
Prior art date
Application number
PT72772A
Other languages
English (en)
Other versions
PT72772A (en
Inventor
Edward J Gragoe Jr
Clarence S Rooney
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PT72772A publication Critical patent/PT72772A/pt
Publication of PT72772B publication Critical patent/PT72772B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/456—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
PT72772A 1980-04-04 1981-03-30 Process for preparing 4-alkylsubstituted-3-hidroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase PT72772B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/137,345 US4428959A (en) 1980-04-04 1980-04-04 4-Alkylsubstituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

Publications (2)

Publication Number Publication Date
PT72772A PT72772A (en) 1981-04-01
PT72772B true PT72772B (en) 1983-02-08

Family

ID=22476981

Family Applications (1)

Application Number Title Priority Date Filing Date
PT72772A PT72772B (en) 1980-04-04 1981-03-30 Process for preparing 4-alkylsubstituted-3-hidroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

Country Status (8)

Country Link
US (1) US4428959A (pt)
EP (1) EP0037991B1 (pt)
JP (1) JPS56154459A (pt)
DE (1) DE3160632D1 (pt)
DK (1) DK153181A (pt)
ES (1) ES501077A0 (pt)
GR (1) GR74130B (pt)
PT (1) PT72772B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7745442B2 (en) * 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
MX2015007797A (es) 2012-12-17 2015-10-05 Parion Sciences Inc Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida.
MX2015007796A (es) 2012-12-17 2015-09-04 Parion Sciences Inc Derivados de cloro-pirazin carboxamida con actividad bloqueadora sobre los canales de sodio epiteliales.
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
US10562844B2 (en) 2015-01-26 2020-02-18 Wake Forest University Health Sciences HYPDH inhibitors and methods of use for the treatment of kidney stones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340263A (en) * 1964-02-14 1967-09-05 Ciba Geigy Corp Amino-pyrroles
US4256758A (en) * 1979-06-11 1981-03-17 Merck & Co., Inc. 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

Also Published As

Publication number Publication date
PT72772A (en) 1981-04-01
ES8205201A1 (es) 1982-06-01
EP0037991A1 (en) 1981-10-21
GR74130B (pt) 1984-06-06
DK153181A (da) 1981-10-05
ES501077A0 (es) 1982-06-01
EP0037991B1 (en) 1983-07-20
JPS56154459A (en) 1981-11-30
DE3160632D1 (en) 1983-08-25
US4428959A (en) 1984-01-31

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