PT717638E - CYCLODEXTRINES FOR THE REDUCTION OF EXTRAVASE TOXICITY CAUSED BY CYTOTOXIC SUBSTANCES - Google Patents

CYCLODEXTRINES FOR THE REDUCTION OF EXTRAVASE TOXICITY CAUSED BY CYTOTOXIC SUBSTANCES

Info

Publication number
PT717638E
PT717638E PT94927983T PT94927983T PT717638E PT 717638 E PT717638 E PT 717638E PT 94927983 T PT94927983 T PT 94927983T PT 94927983 T PT94927983 T PT 94927983T PT 717638 E PT717638 E PT 717638E
Authority
PT
Portugal
Prior art keywords
compositions
cytotoxic
cyclodextrin
ulceration
compound
Prior art date
Application number
PT94927983T
Other languages
Portuguese (pt)
Inventor
Joseph Rubinfeld
Original Assignee
Supergen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Supergen Inc filed Critical Supergen Inc
Publication of PT717638E publication Critical patent/PT717638E/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Compositions of matter comprising a substituted cyclodextrin and cytotoxic compound, especially cytotoxic drugs such as antibiotic, anti-fungal and anti-neoplastic, drugs are claimed. The compositions cause significantly less ulceration compared to the same formulation of cytotoxic compound without cyclodextrin compound when extravasated. The compositions may also cause less vascular irritation compared to the same formulation of cytotoxic compound without cyclodextrin when administered intravenously without extravasation. Compositions of matter comprising watersoluble cytotoxic agents, especially anticancer drugs and anti-ulceration effective or anti-irritatioin effective amounts of cyclodextrin compounds are also claimed. Methods for reducing the likelihood of ulceration and or irritation when administering the compositions according to the invention are also disclosed and claimed.
PT94927983T 1993-09-03 1994-09-02 CYCLODEXTRINES FOR THE REDUCTION OF EXTRAVASE TOXICITY CAUSED BY CYTOTOXIC SUBSTANCES PT717638E (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11672493A 1993-09-03 1993-09-03
US08/297,249 US5602112A (en) 1992-06-19 1994-08-26 Pharmaceutical formulation

Publications (1)

Publication Number Publication Date
PT717638E true PT717638E (en) 2002-07-31

Family

ID=26814548

Family Applications (1)

Application Number Title Priority Date Filing Date
PT94927983T PT717638E (en) 1993-09-03 1994-09-02 CYCLODEXTRINES FOR THE REDUCTION OF EXTRAVASE TOXICITY CAUSED BY CYTOTOXIC SUBSTANCES

Country Status (13)

Country Link
US (6) US5602112A (en)
EP (1) EP0717638B1 (en)
JP (1) JPH09502185A (en)
AT (1) ATE214290T1 (en)
AU (1) AU7718694A (en)
CA (1) CA2172159C (en)
DE (1) DE69430126T2 (en)
DK (1) DK0717638T3 (en)
ES (1) ES2171462T3 (en)
HU (1) HUT73778A (en)
IL (1) IL110825A0 (en)
PT (1) PT717638E (en)
WO (1) WO1995006485A1 (en)

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Also Published As

Publication number Publication date
US6048845A (en) 2000-04-11
EP0717638A1 (en) 1996-06-26
DE69430126T2 (en) 2002-08-01
IL110825A0 (en) 1995-05-26
US6218374B1 (en) 2001-04-17
CA2172159C (en) 2003-07-29
ATE214290T1 (en) 2002-03-15
US6284747B1 (en) 2001-09-04
ES2171462T3 (en) 2002-09-16
US5602112A (en) 1997-02-11
US5804568A (en) 1998-09-08
HU9600612D0 (en) 1996-05-28
CA2172159A1 (en) 1995-03-09
DK0717638T3 (en) 2002-07-01
US6583125B2 (en) 2003-06-24
HUT73778A (en) 1996-09-30
JPH09502185A (en) 1997-03-04
AU7718694A (en) 1995-03-22
EP0717638B1 (en) 2002-03-13
US20020058634A1 (en) 2002-05-16
DE69430126D1 (en) 2002-04-18
WO1995006485A1 (en) 1995-03-09

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