PT3989961T - Uma combinação farmacêutica de um composto de artemisinina, ácido 5-aminolevulínico ou ácido metil-5-aminolevulínico e um agente quimioterapêutico - Google Patents
Uma combinação farmacêutica de um composto de artemisinina, ácido 5-aminolevulínico ou ácido metil-5-aminolevulínico e um agente quimioterapêuticoInfo
- Publication number
- PT3989961T PT3989961T PT217055417T PT21705541T PT3989961T PT 3989961 T PT3989961 T PT 3989961T PT 217055417 T PT217055417 T PT 217055417T PT 21705541 T PT21705541 T PT 21705541T PT 3989961 T PT3989961 T PT 3989961T
- Authority
- PT
- Portugal
- Prior art keywords
- aminolevulinic acid
- methyl
- chemotherapeutic agent
- pharmaceutical combination
- artemisinin compound
- Prior art date
Links
- HJBHOJZDRYXROF-UHFFFAOYSA-N 5-amino-2-methyl-4-oxopentanoic acid Chemical compound OC(=O)C(C)CC(=O)CN HJBHOJZDRYXROF-UHFFFAOYSA-N 0.000 title 1
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 title 1
- 229960002749 aminolevulinic acid Drugs 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 229960004191 artemisinin Drugs 0.000 title 1
- 229930101531 artemisinin Natural products 0.000 title 1
- -1 artemisinin compound Chemical class 0.000 title 1
- 229940127089 cytotoxic agent Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20158341.6A EP3868372A1 (en) | 2020-02-19 | 2020-02-19 | A pharmaceutical combination of an artemisinin compound and a heme synthesis modulator for treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3989961T true PT3989961T (pt) | 2024-02-26 |
Family
ID=69779738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT217055417T PT3989961T (pt) | 2020-02-19 | 2021-02-18 | Uma combinação farmacêutica de um composto de artemisinina, ácido 5-aminolevulínico ou ácido metil-5-aminolevulínico e um agente quimioterapêutico |
Country Status (14)
Country | Link |
---|---|
US (1) | US20230121771A1 (pt) |
EP (2) | EP3868372A1 (pt) |
JP (1) | JP2023514426A (pt) |
KR (1) | KR20220143097A (pt) |
CN (1) | CN114786661A (pt) |
AU (1) | AU2021222339A1 (pt) |
BR (1) | BR112022014692A2 (pt) |
CA (1) | CA3165208A1 (pt) |
DK (1) | DK3989961T3 (pt) |
FI (1) | FI3989961T3 (pt) |
IL (1) | IL294856A (pt) |
PL (1) | PL3989961T3 (pt) |
PT (1) | PT3989961T (pt) |
WO (1) | WO2021165405A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4252001A1 (en) * | 2020-11-30 | 2023-10-04 | Sonalasense, Inc. | Metabolic targeting of low grade tumors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2157424T3 (es) | 1995-03-10 | 2001-08-16 | Photocure Asa | Esteres de acido 5-aminolevulinico como agentes fotosensibilizantes en fotoquimioterapia. |
GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
GB0406917D0 (en) | 2004-03-26 | 2004-04-28 | Photocure Asa | Compounds |
US10925963B2 (en) * | 2015-06-22 | 2021-02-23 | Washington University | Combination artemisinin and chemiluminescent photodynamic therapy and uses therefor |
CN106527586B (zh) * | 2016-11-04 | 2019-09-06 | 吉林省北方医药有限责任公司 | 一种移动终端设备 |
CN108570089B (zh) * | 2017-04-28 | 2019-10-29 | 云白药征武科技(上海)有限公司 | 双氢青蒿素-甾体结合物及其制备方法和应用 |
GB201800736D0 (en) * | 2018-01-17 | 2018-02-28 | St Georges Hospital Medical School | Combination therapy for treatment of leukemia |
CN108635581A (zh) * | 2018-05-23 | 2018-10-12 | 昆药集团股份有限公司 | 一种组合物及其在制备治疗肿瘤的药物中的应用 |
-
2020
- 2020-02-19 EP EP20158341.6A patent/EP3868372A1/en active Pending
-
2021
- 2021-02-18 IL IL294856A patent/IL294856A/en unknown
- 2021-02-18 CN CN202180007033.7A patent/CN114786661A/zh active Pending
- 2021-02-18 EP EP21705541.7A patent/EP3989961B1/en active Active
- 2021-02-18 WO PCT/EP2021/054039 patent/WO2021165405A1/en active Application Filing
- 2021-02-18 FI FIEP21705541.7T patent/FI3989961T3/fi active
- 2021-02-18 DK DK21705541.7T patent/DK3989961T3/da active
- 2021-02-18 PL PL21705541.7T patent/PL3989961T3/pl unknown
- 2021-02-18 AU AU2021222339A patent/AU2021222339A1/en active Pending
- 2021-02-18 JP JP2022550755A patent/JP2023514426A/ja active Pending
- 2021-02-18 PT PT217055417T patent/PT3989961T/pt unknown
- 2021-02-18 KR KR1020227032196A patent/KR20220143097A/ko active Search and Examination
- 2021-02-18 BR BR112022014692A patent/BR112022014692A2/pt unknown
- 2021-02-18 CA CA3165208A patent/CA3165208A1/en active Pending
- 2021-02-18 US US17/801,021 patent/US20230121771A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112022014692A2 (pt) | 2022-09-20 |
EP3868372A1 (en) | 2021-08-25 |
WO2021165405A1 (en) | 2021-08-26 |
EP3989961B1 (en) | 2023-11-22 |
CA3165208A1 (en) | 2021-08-26 |
KR20220143097A (ko) | 2022-10-24 |
JP2023514426A (ja) | 2023-04-05 |
DK3989961T3 (da) | 2024-01-29 |
AU2021222339A1 (en) | 2022-07-28 |
IL294856A (en) | 2022-09-01 |
PL3989961T3 (pl) | 2024-04-08 |
EP3989961A1 (en) | 2022-05-04 |
US20230121771A1 (en) | 2023-04-20 |
CN114786661A (zh) | 2022-07-22 |
FI3989961T3 (fi) | 2024-02-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI3989961T3 (fi) | Artemisiniiniyhdisteen, 5-aminolevuliinihapon tai metyyli-5-aminolevuliinihapon ja kemoterapeuttisen aineen farmaseuttinen yhdistelmä | |
HK1209620A1 (en) | A pharmaceutical composition comprising an omega carboxyaryl substituted diphenyl urea for the treatment of cancer | |
WO2011066980A3 (en) | Oral dosage forms with reduced potential for drug abuse | |
EP4110330A4 (en) | ANTIVIRAL COMPOUNDS AND METHODS OF THEIR ADMINISTRATION | |
ZA202004058B (en) | Combination of an antimuscarinic or an anticholinergic agent and lipoic acid and uses thereof | |
EP4101453A4 (en) | COMBINATION OF BI853520 WITH CHEMOTHERAPEUTIC DRUGS | |
EP2572711A4 (en) | ANTIMALARIAL MEDICINE THAT CONTAINS 5-AMINOLEVULINIC ACID OR A DERIVATIVE AS AN ACTIVE INGREDIENT | |
EP4098258A4 (en) | PHARMACEUTICAL USE OF A CETOAMIDE COMPOUND | |
CA206651S (en) | Pharmaceutical package | |
MX2019014411A (es) | Compuestos que contienen nitrogeno sustituido. | |
EP4103539A4 (en) | COMPOUNDS AND PHARMACEUTICAL USES THEREOF | |
CA202028S (en) | Pharmaceutical package | |
GB202020191D0 (en) | Pharmaceutical compounds | |
WO2011129579A3 (en) | Oral pharmaceutical composition comprising fenofibric acid and an alkalifying agent | |
GB202010409D0 (en) | Pharmaceutical compounds | |
IL287912A (en) | Pharmacy preparation of a weak acid drug and methods of administration | |
WO2010032165A3 (en) | Prodrugs of artemisinin | |
IL284132A (en) | A pharmaceutical compound, a method for its preparation and its use as a medicinal substance | |
EP4058147A4 (en) | NOVEL ANTIMALARIAL AGENT CONTAINING A HETEROCYCLIC COMPOUND | |
GB202005112D0 (en) | Salt of a pharmaceutical compound | |
GB202010408D0 (en) | Pharmaceutical compounds | |
GB202400072D0 (en) | Drug detection | |
GB202217888D0 (en) | Pharmaceutical compound | |
GB202202070D0 (en) | Pharmaceutical compound | |
WO2011115527A8 (ru) | Новое биологически активное соединение n-[3-(4-нитрофениламино)- индол-2-илметилен]аминогуанидина гидрохлорид с противовоспалительной активностью |