PT3024835T - Nova síntese de noroximorfona a partir de morfina - Google Patents

Nova síntese de noroximorfona a partir de morfina

Info

Publication number
PT3024835T
PT3024835T PT147418859T PT14741885T PT3024835T PT 3024835 T PT3024835 T PT 3024835T PT 147418859 T PT147418859 T PT 147418859T PT 14741885 T PT14741885 T PT 14741885T PT 3024835 T PT3024835 T PT 3024835T
Authority
PT
Portugal
Prior art keywords
noroxymorphone
morphine
novel synthesis
synthesis
novel
Prior art date
Application number
PT147418859T
Other languages
English (en)
Inventor
Theodor Weber Beat
Hochstrasser Lisa
Original Assignee
Siegfried Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siegfried Ag filed Critical Siegfried Ag
Publication of PT3024835T publication Critical patent/PT3024835T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT147418859T 2013-07-26 2014-07-22 Nova síntese de noroximorfona a partir de morfina PT3024835T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13178119.7A EP2829541A1 (en) 2013-07-26 2013-07-26 Novel synthesis of noroxymorphone from morphine

Publications (1)

Publication Number Publication Date
PT3024835T true PT3024835T (pt) 2018-03-26

Family

ID=48874190

Family Applications (1)

Application Number Title Priority Date Filing Date
PT147418859T PT3024835T (pt) 2013-07-26 2014-07-22 Nova síntese de noroximorfona a partir de morfina

Country Status (7)

Country Link
US (1) US9546177B2 (pt)
EP (2) EP2829541A1 (pt)
AU (1) AU2014295155B2 (pt)
CA (1) CA2914654C (pt)
ES (1) ES2669546T3 (pt)
PT (1) PT3024835T (pt)
WO (1) WO2015011131A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024501153A (ja) * 2020-12-28 2024-01-11 ナヴィン サクセナ リサーチ アンド テクノロジー ピーブイティー．エルティーディー． モルヒネからのノルオキシモルフォンの合成のための新規方法
CN113105019A (zh) * 2021-04-08 2021-07-13 广西国睿工程咨询有限公司 一种药厂废液中吗啡的分解方法
US11247999B1 (en) * 2021-07-02 2022-02-15 Joseph DeGraw Facile conversion of morphine to normorphine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
US4472253A (en) 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US4795813A (en) 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
IT1199871B (it) 1984-03-27 1989-01-05 Mallinckrodt Inc Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento
US5112975A (en) 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
EP2377866B1 (en) 2010-03-23 2014-02-26 Siegfried AG Preparation of low impurity opiates in a continuous flow reactor

Also Published As

Publication number Publication date
CA2914654C (en) 2021-07-20
EP2829541A1 (en) 2015-01-28
CA2914654A1 (en) 2015-01-29
WO2015011131A1 (en) 2015-01-29
EP3024835A1 (en) 2016-06-01
EP3024835B1 (en) 2018-02-21
US9546177B2 (en) 2017-01-17
AU2014295155A1 (en) 2015-12-24
US20160159812A1 (en) 2016-06-09
AU2014295155B2 (en) 2018-01-18
ES2669546T3 (es) 2018-05-28

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