PT2773337T - Utilização de agentes anti-conexina para intensificar o efeito terapêutico de inibidores da acetilcolinesterase - Google Patents
Utilização de agentes anti-conexina para intensificar o efeito terapêutico de inibidores da acetilcolinesteraseInfo
- Publication number
- PT2773337T PT2773337T PT12778762T PT12778762T PT2773337T PT 2773337 T PT2773337 T PT 2773337T PT 12778762 T PT12778762 T PT 12778762T PT 12778762 T PT12778762 T PT 12778762T PT 2773337 T PT2773337 T PT 2773337T
- Authority
- PT
- Portugal
- Prior art keywords
- enhancing
- therapeutic effect
- acetylcholinesterase inhibitors
- connexin agents
- connexin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11306407.5A EP2586436A1 (en) | 2011-10-31 | 2011-10-31 | Use of anti-connexin agents for enhancing the therapeutic effect of acetylcholinesterase inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2773337T true PT2773337T (pt) | 2018-12-20 |
Family
ID=47080551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT12778762T PT2773337T (pt) | 2011-10-31 | 2012-10-31 | Utilização de agentes anti-conexina para intensificar o efeito terapêutico de inibidores da acetilcolinesterase |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20150011584A1 (pt) |
| EP (3) | EP2586436A1 (pt) |
| JP (1) | JP6053805B2 (pt) |
| CN (1) | CN103906511B (pt) |
| AU (2) | AU2012331136B2 (pt) |
| CA (1) | CA2853325C (pt) |
| DK (1) | DK2773337T3 (pt) |
| ES (1) | ES2701048T3 (pt) |
| HR (1) | HRP20182043T8 (pt) |
| HU (1) | HUE042671T2 (pt) |
| IL (2) | IL232292A0 (pt) |
| PL (1) | PL2773337T3 (pt) |
| PT (1) | PT2773337T (pt) |
| WO (1) | WO2013064579A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0519737A2 (pt) * | 2004-12-21 | 2009-01-27 | Musc Found For Res Dev | composiÇÕes e mÉtodos para promover a cura de feridas e a regeneraÇço de tecidos |
| PL3024458T3 (pl) * | 2013-07-24 | 2018-08-31 | Commissariat à l'énergie atomique et aux énergies alternatives | Zastosowanie flekainidu jako środka anty-koneksynowego oraz sposób wzmacniania efektów działania leku psychotropowego |
| WO2015035258A1 (en) * | 2013-09-06 | 2015-03-12 | The Rockefeller University | Treatment and prevention of autism and autism spectrum disorders |
| WO2016205193A1 (en) * | 2015-06-15 | 2016-12-22 | Rush Unversity Medical Center | BRAIN DERIVED PPARα LIGANDS |
| US10864192B2 (en) * | 2016-01-15 | 2020-12-15 | Aristea Translational Medicine Corporation | Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions |
| US10111860B1 (en) * | 2016-01-15 | 2018-10-30 | Aristea Translational Medicine Corporation | Compositions and methods for treating concussion |
| AU2018341235A1 (en) | 2017-09-28 | 2020-05-07 | Asdera Llc | Use of cyclodextrins in diseases and disorders involving phospholipid dysregulation |
| EP3593822A1 (en) | 2018-07-13 | 2020-01-15 | Theranexus | Therapeutic and diagnostic applications of a new method of monitoring of neuroglial interaction memri) |
| FR3110393B1 (fr) | 2020-05-20 | 2022-05-06 | Grn Consulting | Compose et composition pour induire une neuroprotection |
| FR3128872A1 (fr) | 2021-11-08 | 2023-05-12 | Rest Therapeutics | Nouvelles combinaisons synergiques a base de fenm |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999026627A1 (en) | 1997-11-26 | 1999-06-03 | Cerebrus Limited | (-)-mefloquine to block purinergic receptors and to treat movement or neurodegenerative disorders |
| US20080021085A1 (en) * | 2000-04-13 | 2008-01-24 | Mayo Foundation For Medical Education And Research | Method of reducing abeta42 and treating diseases |
| AU2001257022B2 (en) * | 2000-04-13 | 2005-02-03 | Mayo Foundation For Medical Education And Research | Abeta 42 lowering agents |
| DE10119862A1 (de) * | 2001-04-24 | 2002-11-07 | Hf Arzneimittelforsch Gmbh | Verwendung von Galanthamin zur Behandlung von Krankheitserscheinungen des zentralen Nervensystems aufgrund von Intoxikationen mit psychotropen Substanzen |
| WO2004091522A2 (en) | 2003-04-11 | 2004-10-28 | Myriad Genetics, Inc. | Method for treating neurodegenerative disorders |
| CA2508585A1 (en) * | 2004-06-01 | 2005-12-01 | Axonyx, Inc. | Transdermal delivery system for treatment of cognitive disorders |
| HUP0401850A3 (en) | 2004-09-15 | 2008-03-28 | Egis Gyogyszergyar Nyilvanosan | Donepezil salts for producing pharmaceutical composition |
| US20060194723A1 (en) * | 2005-02-28 | 2006-08-31 | Rabinoff Michael D | Novel medication treatment and delivery strategies for Alzheimer's Disease, other disorders with memory impairment, and possible treatment strategies for memory improvement |
| US8021701B1 (en) * | 2005-04-13 | 2011-09-20 | Perry Stephen C | Composition to retard the onset of symptoms of alzheimer's disease |
| FR2935611B1 (fr) * | 2008-09-10 | 2010-10-15 | Commissariat Energie Atomique | Utilisation d'agents anti-connexines pour moduler l'effet therapeutique de molecules psychotropes |
| CN101991859A (zh) * | 2009-10-27 | 2011-03-30 | 上海复旦复华药业有限公司 | 一种石杉碱甲的β-环糊精包合物及其制备方法和制剂 |
-
2011
- 2011-10-31 EP EP11306407.5A patent/EP2586436A1/en not_active Withdrawn
-
2012
- 2012-10-31 ES ES12778762T patent/ES2701048T3/es active Active
- 2012-10-31 PT PT12778762T patent/PT2773337T/pt unknown
- 2012-10-31 DK DK12778762.0T patent/DK2773337T3/en active
- 2012-10-31 AU AU2012331136A patent/AU2012331136B2/en not_active Ceased
- 2012-10-31 PL PL12778762T patent/PL2773337T3/pl unknown
- 2012-10-31 CN CN201280053256.8A patent/CN103906511B/zh not_active Expired - Fee Related
- 2012-10-31 EP EP12778762.0A patent/EP2773337B1/en active Active
- 2012-10-31 EP EP18195298.7A patent/EP3446688A1/en not_active Withdrawn
- 2012-10-31 WO PCT/EP2012/071631 patent/WO2013064579A1/en active Application Filing
- 2012-10-31 HU HUE12778762A patent/HUE042671T2/hu unknown
- 2012-10-31 JP JP2014537665A patent/JP6053805B2/ja not_active Expired - Fee Related
- 2012-10-31 US US14/355,153 patent/US20150011584A1/en not_active Abandoned
- 2012-10-31 CA CA2853325A patent/CA2853325C/en active Active
-
2014
- 2014-04-28 IL IL232292A patent/IL232292A0/en unknown
-
2017
- 2017-09-11 AU AU2017228472A patent/AU2017228472B2/en not_active Ceased
-
2018
- 2018-02-23 US US15/903,662 patent/US10765670B2/en active Active
- 2018-12-05 HR HRP20182043TT patent/HRP20182043T8/hr unknown
-
2019
- 2019-11-18 IL IL270748A patent/IL270748B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017228472B2 (en) | 2019-07-11 |
| IL232292A0 (en) | 2014-06-30 |
| AU2017228472A1 (en) | 2017-10-05 |
| EP2773337B1 (en) | 2018-09-19 |
| HRP20182043T1 (hr) | 2019-04-19 |
| ES2701048T3 (es) | 2019-02-20 |
| CA2853325C (en) | 2021-08-24 |
| IL270748A (en) | 2020-01-30 |
| AU2012331136A1 (en) | 2014-05-01 |
| CA2853325A1 (en) | 2013-05-10 |
| EP3446688A1 (en) | 2019-02-27 |
| DK2773337T3 (en) | 2018-12-10 |
| IL270748B (en) | 2021-10-31 |
| PL2773337T3 (pl) | 2019-04-30 |
| AU2012331136B2 (en) | 2017-06-29 |
| EP2586436A1 (en) | 2013-05-01 |
| CN103906511B (zh) | 2016-04-06 |
| US10765670B2 (en) | 2020-09-08 |
| US20150011584A1 (en) | 2015-01-08 |
| HUE042671T2 (hu) | 2019-07-29 |
| JP6053805B2 (ja) | 2016-12-27 |
| WO2013064579A1 (en) | 2013-05-10 |
| HRP20182043T8 (hr) | 2019-06-14 |
| US20180177773A1 (en) | 2018-06-28 |
| EP2773337A1 (en) | 2014-09-10 |
| JP2014532635A (ja) | 2014-12-08 |
| CN103906511A (zh) | 2014-07-02 |
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