PT2729004T - Tratamento de acidúria metilmalónica, acidúria isovalérica, e outras acidúrias orgânicas com tocotrienol quinonas - Google Patents
Tratamento de acidúria metilmalónica, acidúria isovalérica, e outras acidúrias orgânicas com tocotrienol quinonasInfo
- Publication number
- PT2729004T PT2729004T PT128077351T PT12807735T PT2729004T PT 2729004 T PT2729004 T PT 2729004T PT 128077351 T PT128077351 T PT 128077351T PT 12807735 T PT12807735 T PT 12807735T PT 2729004 T PT2729004 T PT 2729004T
- Authority
- PT
- Portugal
- Prior art keywords
- aciduria
- treatment
- isovaleric
- methylmalonic
- tocotrienol quinones
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161505051P | 2011-07-06 | 2011-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2729004T true PT2729004T (pt) | 2020-06-08 |
Family
ID=47437452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT128077351T PT2729004T (pt) | 2011-07-06 | 2012-07-05 | Tratamento de acidúria metilmalónica, acidúria isovalérica, e outras acidúrias orgânicas com tocotrienol quinonas |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20150057363A1 (pt) |
| EP (1) | EP2729004B1 (pt) |
| JP (3) | JP6728520B2 (pt) |
| ES (1) | ES2795798T3 (pt) |
| PT (1) | PT2729004T (pt) |
| WO (1) | WO2013006737A1 (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2580584C (en) | 2003-09-19 | 2015-07-28 | Galileo Pharmaceuticals, Inc. | Use of alpha-tocotrienol for treatment of mitochondrial diseases |
| ES2714900T3 (es) | 2005-06-01 | 2019-05-30 | Bioelectron Tech Corp | Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos |
| WO2007100652A2 (en) | 2006-02-22 | 2007-09-07 | Edison Pharmaceuticals, Inc. | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| CA2704473C (en) | 2007-11-06 | 2016-10-04 | Edison Pharmaceuticals, Inc. | 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| EP2237664A4 (en) | 2008-01-08 | 2013-05-22 | Edison Pharmaceuticals Inc | (HET) ARYL-p-CHINONE DERIVATIVES FOR THE TREATMENT OF OCHONDRIAL DISEASES |
| WO2009111576A2 (en) | 2008-03-05 | 2009-09-11 | Edison Pharmaceuticals, Inc. | 2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES |
| CA2729227C (en) | 2008-06-25 | 2018-05-22 | Andrew W. Hinman | 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases |
| LT3827815T (lt) | 2008-09-10 | 2023-10-10 | Ptc Therapeutics, Inc. | Psichologinių raidos sutrikimų gydymas oksidacijos redukcijos atžvilgiu aktyviais vaistais |
| US10039722B2 (en) | 2008-10-14 | 2018-08-07 | Bioelectron Technology Corporation | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| SI2963006T1 (sl) | 2008-10-28 | 2019-01-31 | Bioelectron Technology Corporation | Sestavek vsebujoč alfa-tokotrienol kinon in njegove vmesne povezave |
| JP2012525399A (ja) | 2009-04-28 | 2012-10-22 | エジソン ファーマシューティカルズ， インコーポレイテッド | トコトリエノールキノンを用いる、レーバー遺伝性視神経症および優性遺伝性視神経萎縮症の治療 |
| WO2012174286A1 (en) | 2011-06-14 | 2012-12-20 | Edison Pharmaceuticals, Inc. | Catechol derivatives for treatment of oxidative stress diseases |
| JP2014520894A (ja) | 2011-07-19 | 2014-08-25 | エジソン ファーマシューティカルズ， インコーポレイテッド | 非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法 |
| US20150216820A1 (en) | 2012-09-07 | 2015-08-06 | Edison Pharmaceuticals, Inc. | Quinone derivatives for use in the modulation of redox status of individuals |
| CA2906145A1 (en) | 2013-03-15 | 2014-09-18 | Edison Pharmaceuticals, Inc. | Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| HUE058877T2 (hu) | 2014-12-16 | 2022-09-28 | Ptc Therapeutics Inc | (R)-2-hidroxi-2-metil-4-(2,4,5-trimetil-3,6-dioxociklohexa-1,4-dienil)butánamid polimorf és amorf alakjai |
| EP3390377A1 (en) | 2015-12-16 | 2018-10-24 | BioElectron Technology Corporation | Improved methods for enriching alpha-tocotrienol from mixed tocol compositions |
| CA3008849A1 (en) | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| US11083702B2 (en) | 2016-04-19 | 2021-08-10 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anaplerotic agents for treatment of disorders of propionate and long chain fat metabolism |
| JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 |
| EP4257190A3 (en) | 2018-10-17 | 2024-01-03 | PTC Therapeutics, Inc. | 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating alpha-synucleinopathies, tauopathies, and other disorders |
| CN114364664A (zh) * | 2019-07-09 | 2022-04-15 | 伊卡根有限责任公司 | Bcat调节 |
| IL310011A (en) | 2021-07-08 | 2024-03-01 | Ptc Therapeutics Inc | Pharmaceutical compositions containing 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0204232D0 (en) | 2002-02-22 | 2002-04-10 | Isis Innovation | Assay |
| EP1378753B1 (en) | 2002-07-01 | 2006-05-31 | Santhera Pharmaceuticals (Schweiz) GmbH | A screening method and compounds for treating Friedreich Ataxia |
| EP1587960A2 (en) * | 2003-01-30 | 2005-10-26 | Research Development Foundation | Methods and compositions for analysis of mitochondrial-related gene expression |
| ES2714900T3 (es) * | 2005-06-01 | 2019-05-30 | Bioelectron Tech Corp | Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos |
| EP1749552A1 (en) * | 2005-07-29 | 2007-02-07 | Neuropharma S.A. | Use of collismycin and derivatives thereof as oxidative stress inhibitors |
| EP2424494A1 (en) * | 2009-04-28 | 2012-03-07 | Edison Pharmaceuticals, Inc. | Formulation of tocotrienol quinones for the treatment of ophthalmic diseases |
| JP2012525399A (ja) * | 2009-04-28 | 2012-10-22 | エジソン ファーマシューティカルズ， インコーポレイテッド | トコトリエノールキノンを用いる、レーバー遺伝性視神経症および優性遺伝性視神経萎縮症の治療 |
| WO2011072281A1 (en) * | 2009-12-11 | 2011-06-16 | Ptc Therapeutics, Inc. | Methods for treating methylmalonic acidemia |
-
2012
- 2012-07-05 US US14/130,903 patent/US20150057363A1/en not_active Abandoned
- 2012-07-05 JP JP2014519307A patent/JP6728520B2/ja active Active
- 2012-07-05 ES ES12807735T patent/ES2795798T3/es active Active
- 2012-07-05 EP EP12807735.1A patent/EP2729004B1/en active Active
- 2012-07-05 PT PT128077351T patent/PT2729004T/pt unknown
- 2012-07-05 WO PCT/US2012/045628 patent/WO2013006737A1/en active Application Filing
-
2017
- 2017-12-01 JP JP2017231924A patent/JP2018030892A/ja active Pending
-
2018
- 2018-06-26 US US16/019,363 patent/US20180303770A1/en not_active Abandoned
-
2019
- 2019-11-28 JP JP2019215845A patent/JP2020029465A/ja not_active Withdrawn
-
2020
- 2020-09-17 US US17/024,664 patent/US20210145769A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150057363A1 (en) | 2015-02-26 |
| EP2729004A1 (en) | 2014-05-14 |
| US20180303770A1 (en) | 2018-10-25 |
| JP2020029465A (ja) | 2020-02-27 |
| JP2014528914A (ja) | 2014-10-30 |
| EP2729004A4 (en) | 2014-11-19 |
| JP2018030892A (ja) | 2018-03-01 |
| US20210145769A1 (en) | 2021-05-20 |
| EP2729004B1 (en) | 2020-03-25 |
| ES2795798T3 (es) | 2020-11-24 |
| JP6728520B2 (ja) | 2020-07-22 |
| WO2013006737A1 (en) | 2013-01-10 |
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