PT2717883T - Proteção contra disfunção de barreira endotelial através de inibição do gene relacionado com abl de tirosina quinase (arg) - Google Patents
Proteção contra disfunção de barreira endotelial através de inibição do gene relacionado com abl de tirosina quinase (arg)Info
- Publication number
- PT2717883T PT2717883T PT117311423T PT11731142T PT2717883T PT 2717883 T PT2717883 T PT 2717883T PT 117311423 T PT117311423 T PT 117311423T PT 11731142 T PT11731142 T PT 11731142T PT 2717883 T PT2717883 T PT 2717883T
- Authority
- PT
- Portugal
- Prior art keywords
- arg
- inhibition
- tyrosine kinase
- protection against
- related gene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/NL2011/050299 WO2012150857A1 (en) | 2011-05-02 | 2011-05-02 | Protection against endothelial barrier dysfunction through inhibition of the tyrosine kinase abl-related gene (arg) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2717883T true PT2717883T (pt) | 2017-04-19 |
Family
ID=44583314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT117311423T PT2717883T (pt) | 2011-05-02 | 2011-05-02 | Proteção contra disfunção de barreira endotelial através de inibição do gene relacionado com abl de tirosina quinase (arg) |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9290765B2 (pt) |
| EP (1) | EP2717883B1 (pt) |
| DK (1) | DK2717883T3 (pt) |
| ES (1) | ES2622112T3 (pt) |
| HR (1) | HRP20170553T1 (pt) |
| LT (1) | LT2717883T (pt) |
| PL (1) | PL2717883T3 (pt) |
| PT (1) | PT2717883T (pt) |
| SI (1) | SI2717883T1 (pt) |
| WO (1) | WO2012150857A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2717883T (lt) | 2011-05-02 | 2017-04-25 | Stichting Vumc | Apsauga nuo endotelio barjero disfunkcijos, slopinant su abl susijusio geno (arg) tirozino kinazę |
| EP2846787B1 (en) | 2012-05-08 | 2018-08-29 | Aeromics, Inc. | Compounds for use in the treatment of aquaporin-mediated diseases |
| RU2691951C2 (ru) | 2013-11-06 | 2019-06-19 | Аэромикс, Инк. | Новые составы |
| WO2018013912A1 (en) * | 2016-07-15 | 2018-01-18 | The Board Of Regents Of The University Of Oklahoma | Anti-arid3a treatments for inflammatory disorders |
| CN112852853B (zh) * | 2021-01-08 | 2023-06-02 | 重庆医科大学附属儿童医院 | 一种高强度聚焦超声生物靶向增效剂及运用 |
| EP4046639A1 (en) | 2021-02-22 | 2022-08-24 | Stichting VUmc | Prevention of pulmonary vascular leak in covid-19 |
| GB202204070D0 (en) | 2022-03-23 | 2022-05-04 | Exvastat Ltd | Treatment |
| US11752152B1 (en) | 2022-04-25 | 2023-09-12 | Exvastat Ltd | Pharmaceutical formulations of imatinib and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| US6774288B1 (en) | 1997-07-07 | 2004-08-10 | Basf Plant Science L.L.C. | Animal feed with low phytic acid, oil, burdened and protein laden grain |
| RU2260592C9 (ru) | 1999-04-15 | 2017-04-07 | Бристол-Маерс Сквибб Ко. | Циклические ингибиторы протеинтирозинкиназ |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| EP1560931B1 (en) | 2002-11-14 | 2011-07-27 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| US7846906B2 (en) | 2003-02-28 | 2010-12-07 | Isis Pharmaceuticals, Inc. | Modulation of growth hormone receptor expression and insulin-like growth factor expression |
| WO2005047505A2 (en) | 2003-08-07 | 2005-05-26 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro rnas |
| CA2687336C (en) | 2007-05-23 | 2014-12-23 | Dharmacon, Inc. | Micro-rna scaffolds and non-naturally occurring micro-rnas |
| AU2008329327B2 (en) | 2007-11-26 | 2015-07-16 | Roche Innovation Center Copenhagen A/S | LNA antagonists targeting the androgen receptor |
| LT2717883T (lt) | 2011-05-02 | 2017-04-25 | Stichting Vumc | Apsauga nuo endotelio barjero disfunkcijos, slopinant su abl susijusio geno (arg) tirozino kinazę |
-
2011
- 2011-05-02 LT LTEP11731142.3T patent/LT2717883T/lt unknown
- 2011-05-02 SI SI201131153A patent/SI2717883T1/sl unknown
- 2011-05-02 WO PCT/NL2011/050299 patent/WO2012150857A1/en active Application Filing
- 2011-05-02 PL PL11731142T patent/PL2717883T3/pl unknown
- 2011-05-02 DK DK11731142.3T patent/DK2717883T3/en active
- 2011-05-02 EP EP11731142.3A patent/EP2717883B1/en active Active
- 2011-05-02 PT PT117311423T patent/PT2717883T/pt unknown
- 2011-05-02 US US14/115,279 patent/US9290765B2/en active Active
- 2011-05-02 ES ES11731142.3T patent/ES2622112T3/es active Active
-
2017
- 2017-04-05 HR HRP20170553TT patent/HRP20170553T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012150857A1 (en) | 2012-11-08 |
| HRP20170553T1 (hr) | 2017-06-02 |
| LT2717883T (lt) | 2017-04-25 |
| DK2717883T3 (en) | 2017-04-24 |
| SI2717883T1 (sl) | 2017-06-30 |
| EP2717883B1 (en) | 2017-03-22 |
| ES2622112T3 (es) | 2017-07-05 |
| PL2717883T3 (pl) | 2017-07-31 |
| US20140187605A1 (en) | 2014-07-03 |
| US9290765B2 (en) | 2016-03-22 |
| EP2717883A1 (en) | 2014-04-16 |
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