LT2717883T - Apsauga nuo endotelio barjero disfunkcijos, slopinant su abl susijusio geno (arg) tirozino kinazę - Google Patents

Apsauga nuo endotelio barjero disfunkcijos, slopinant su abl susijusio geno (arg) tirozino kinazę

Info

Publication number
LT2717883T
LT2717883T LTEP11731142.3T LT11731142T LT2717883T LT 2717883 T LT2717883 T LT 2717883T LT 11731142 T LT11731142 T LT 11731142T LT 2717883 T LT2717883 T LT 2717883T
Authority
LT
Lithuania
Prior art keywords
arg
inhibition
tyrosine kinase
protection against
related gene
Prior art date
Application number
LTEP11731142.3T
Other languages
English (en)
Inventor
Geerten P. VAN NIEUW AMERONGEN
Anton VONK NOORDEGRAAF
Jurjan AMAN
Victor W. M. VAN HINSBERGH
Original Assignee
Stichting Vumc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Vumc filed Critical Stichting Vumc
Publication of LT2717883T publication Critical patent/LT2717883T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LTEP11731142.3T 2011-05-02 2011-05-02 Apsauga nuo endotelio barjero disfunkcijos, slopinant su abl susijusio geno (arg) tirozino kinazę LT2717883T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/NL2011/050299 WO2012150857A1 (en) 2011-05-02 2011-05-02 Protection against endothelial barrier dysfunction through inhibition of the tyrosine kinase abl-related gene (arg)

Publications (1)

Publication Number Publication Date
LT2717883T true LT2717883T (lt) 2017-04-25

Family

ID=44583314

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP11731142.3T LT2717883T (lt) 2011-05-02 2011-05-02 Apsauga nuo endotelio barjero disfunkcijos, slopinant su abl susijusio geno (arg) tirozino kinazę

Country Status (10)

Country Link
US (1) US9290765B2 (lt)
EP (1) EP2717883B1 (lt)
DK (1) DK2717883T3 (lt)
ES (1) ES2622112T3 (lt)
HR (1) HRP20170553T1 (lt)
LT (1) LT2717883T (lt)
PL (1) PL2717883T3 (lt)
PT (1) PT2717883T (lt)
SI (1) SI2717883T1 (lt)
WO (1) WO2012150857A1 (lt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9290765B2 (en) 2011-05-02 2016-03-22 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Protection against endothelial barrier dysfunction through inhibition of the tyrosine kinase abl-related gene (ARG)
KR102200176B1 (ko) 2012-05-08 2021-01-11 에어로믹스, 인코포레이티드 신규 방법
US9949991B2 (en) 2013-11-06 2018-04-24 Aeromics, Inc. Methods of treating aquaporin-mediated conditions
US10876116B2 (en) 2016-07-15 2020-12-29 The Board Of Regents Of The University Of Oklahoma Anti-ARID3a treatments for inflammatory disorders
CN112852853B (zh) * 2021-01-08 2023-06-02 重庆医科大学附属儿童医院 一种高强度聚焦超声生物靶向增效剂及运用
EP4046639A1 (en) 2021-02-22 2022-08-24 Stichting VUmc Prevention of pulmonary vascular leak in covid-19
GB202204070D0 (en) 2022-03-23 2022-05-04 Exvastat Ltd Treatment
US11752152B1 (en) 2022-04-25 2023-09-12 Exvastat Ltd Pharmaceutical formulations of imatinib and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
US6774288B1 (en) 1997-07-07 2004-08-10 Basf Plant Science L.L.C. Animal feed with low phytic acid, oil, burdened and protein laden grain
PT1169038E (pt) 1999-04-15 2012-10-26 Bristol Myers Squibb Co Inibidores cíclicos da proteína tirosina cinase
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
DK2284266T3 (da) 2002-11-14 2014-01-13 Thermo Fisher Scient Biosciences Inc sIRNA-MOLEKYLE MOD TP53
US7846906B2 (en) 2003-02-28 2010-12-07 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
US8106180B2 (en) 2003-08-07 2012-01-31 Whitehead Institute For Biomedical Research Methods and products for expression of micro RNAs
EP2155911B1 (en) 2007-05-23 2013-08-28 Dharmacon, Inc. Micro-RNA scaffolds, non-naturally occurring micro-RNAs, and methods for optimizing non-naturally occurring micro-RNAs
UA100253C2 (uk) 2007-11-26 2012-12-10 Сантаріс Фарма А/С Lna-антагоністи андрогенного рецептора
US9290765B2 (en) 2011-05-02 2016-03-22 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Protection against endothelial barrier dysfunction through inhibition of the tyrosine kinase abl-related gene (ARG)

Also Published As

Publication number Publication date
ES2622112T3 (es) 2017-07-05
PT2717883T (pt) 2017-04-19
EP2717883A1 (en) 2014-04-16
HRP20170553T1 (hr) 2017-06-02
EP2717883B1 (en) 2017-03-22
DK2717883T3 (en) 2017-04-24
WO2012150857A1 (en) 2012-11-08
US20140187605A1 (en) 2014-07-03
PL2717883T3 (pl) 2017-07-31
SI2717883T1 (sl) 2017-06-30
US9290765B2 (en) 2016-03-22

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