PT2240172E - Combinação de nilotinib e clorambucilo para o tratamento da leucemia linfocítica crónica - Google Patents
Combinação de nilotinib e clorambucilo para o tratamento da leucemia linfocítica crónica Download PDFInfo
- Publication number
- PT2240172E PT2240172E PT88648910T PT08864891T PT2240172E PT 2240172 E PT2240172 E PT 2240172E PT 88648910 T PT88648910 T PT 88648910T PT 08864891 T PT08864891 T PT 08864891T PT 2240172 E PT2240172 E PT 2240172E
- Authority
- PT
- Portugal
- Prior art keywords
- nilotinib
- chlorambucil
- treatment
- combination
- lymphocytic leukemia
- Prior art date
Links
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 title 1
- 239000005536 L01XE08 - Nilotinib Substances 0.000 title 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 title 1
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 title 1
- 229960004630 chlorambucil Drugs 0.000 title 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 title 1
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 title 1
- 229960001346 nilotinib Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1570407P | 2007-12-21 | 2007-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2240172E true PT2240172E (pt) | 2014-05-28 |
Family
ID=40352369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT88648910T PT2240172E (pt) | 2007-12-21 | 2008-12-18 | Combinação de nilotinib e clorambucilo para o tratamento da leucemia linfocítica crónica |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20110028422A1 (enExample) |
| EP (1) | EP2240172B1 (enExample) |
| JP (2) | JP2011507880A (enExample) |
| ES (1) | ES2459877T3 (enExample) |
| PL (1) | PL2240172T3 (enExample) |
| PT (1) | PT2240172E (enExample) |
| WO (1) | WO2009082662A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2425830A1 (en) * | 2010-09-03 | 2012-03-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Synergistic drug combination for the treatment of cancer |
| JP6280546B2 (ja) | 2012-06-26 | 2018-02-14 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| EP2983674A4 (en) | 2013-04-08 | 2017-05-10 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
| CN106102722A (zh) * | 2014-03-13 | 2016-11-09 | V·沃道里斯 | 苯达莫司汀固体分散体和连续输液 |
| US9777572B2 (en) * | 2014-11-17 | 2017-10-03 | Baker Hughes Incorporated | Multi-probe reservoir sampling device |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3046301A (en) | 1959-10-29 | 1962-07-24 | Burroughs Wellcome Co | Method of making chlorambucil |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| BR0316126A (pt) * | 2002-11-12 | 2005-09-27 | Jewish General Hospital | Combinação de compostos para o tratamento de leucemia linfocìtica crÈnica |
| GT200600315A (es) * | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida |
-
2008
- 2008-12-18 EP EP08864891.0A patent/EP2240172B1/en not_active Not-in-force
- 2008-12-18 JP JP2010539775A patent/JP2011507880A/ja active Pending
- 2008-12-18 US US12/809,805 patent/US20110028422A1/en not_active Abandoned
- 2008-12-18 ES ES08864891.0T patent/ES2459877T3/es active Active
- 2008-12-18 PT PT88648910T patent/PT2240172E/pt unknown
- 2008-12-18 PL PL08864891T patent/PL2240172T3/pl unknown
- 2008-12-18 WO PCT/US2008/087336 patent/WO2009082662A1/en not_active Ceased
-
2014
- 2014-06-03 JP JP2014115061A patent/JP2014177487A/ja active Pending
- 2014-10-27 US US14/524,493 patent/US20150051236A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009082662A1 (en) | 2009-07-02 |
| EP2240172A1 (en) | 2010-10-20 |
| ES2459877T3 (es) | 2014-05-12 |
| JP2014177487A (ja) | 2014-09-25 |
| PL2240172T3 (pl) | 2014-08-29 |
| US20150051236A1 (en) | 2015-02-19 |
| EP2240172B1 (en) | 2014-03-19 |
| JP2011507880A (ja) | 2011-03-10 |
| US20110028422A1 (en) | 2011-02-03 |
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