PT1976880T - Pharmaceutical compositions with resistance to soluble cea - Google Patents
Pharmaceutical compositions with resistance to soluble ceaInfo
- Publication number
- PT1976880T PT1976880T PT68411123T PT06841112T PT1976880T PT 1976880 T PT1976880 T PT 1976880T PT 68411123 T PT68411123 T PT 68411123T PT 06841112 T PT06841112 T PT 06841112T PT 1976880 T PT1976880 T PT 1976880T
- Authority
- PT
- Portugal
- Prior art keywords
- resistance
- pharmaceutical compositions
- soluble cea
- cea
- soluble
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75196305P | 2005-12-21 | 2005-12-21 | |
EP05028064 | 2005-12-21 | ||
US78086106P | 2006-03-10 | 2006-03-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1976880T true PT1976880T (en) | 2016-09-28 |
Family
ID=40413962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT68411123T PT1976880T (en) | 2005-12-21 | 2006-12-21 | Pharmaceutical compositions with resistance to soluble cea |
Country Status (25)
Country | Link |
---|---|
US (3) | US8394926B2 (en) |
EP (2) | EP1976880B1 (en) |
JP (2) | JP5399712B2 (en) |
KR (1) | KR101287777B1 (en) |
CN (1) | CN101370827B (en) |
AU (1) | AU2006328886C1 (en) |
BR (1) | BRPI0620632A2 (en) |
CA (1) | CA2633766C (en) |
CY (1) | CY1118053T1 (en) |
DK (1) | DK1976880T3 (en) |
ES (1) | ES2595091T3 (en) |
HK (1) | HK1115890A1 (en) |
HR (1) | HRP20161216T1 (en) |
HU (1) | HUE031151T2 (en) |
IL (1) | IL192277A (en) |
LT (1) | LT1976880T (en) |
ME (1) | ME02581B (en) |
NZ (1) | NZ569204A (en) |
PL (1) | PL1976880T3 (en) |
PT (1) | PT1976880T (en) |
RS (1) | RS55181B1 (en) |
RU (2) | RU2426743C2 (en) |
SG (1) | SG193141A1 (en) |
WO (1) | WO2007071426A1 (en) |
ZA (1) | ZA200805400B (en) |
Families Citing this family (69)
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DE10254601A1 (en) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Gene products differentially expressed in tumors and their use |
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CA2633756C (en) * | 2005-12-21 | 2015-11-24 | Micromet Ag | Pharmaceutical antibody compositions with resistance to soluble cea |
PL1976880T3 (en) | 2005-12-21 | 2017-01-31 | Amgen Research (Munich) Gmbh | Pharmaceutical compositions with resistance to soluble cea |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
BRPI0810120A2 (en) | 2007-04-27 | 2014-11-11 | Dow Global Technologies Inc | PROCESS TO QUICKLY SELECT MICROBIAN HOST FOR THE IDENTIFICATION OF CERTAIN BETTER YIELDS AND / OR QUALITY IN EXPRESSION OF HETEROLOGICAL PROTEINS |
JP5490714B2 (en) * | 2007-11-28 | 2014-05-14 | メディミューン,エルエルシー | Protein preparation |
GB0908613D0 (en) * | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
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EP2507628A4 (en) * | 2009-12-01 | 2013-04-24 | Medimmune Llc | Improved methods and compositions for detecting and treating cea-expressing cancers |
EP3604339B1 (en) | 2011-01-14 | 2021-03-10 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
US20140242081A1 (en) * | 2011-07-18 | 2014-08-28 | Micromet Ag | Dosing regimens for treatment of cea-expressing cancers |
WO2013054320A1 (en) * | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
US9783610B2 (en) | 2012-04-27 | 2017-10-10 | The Trustees Of The University Of Pennsylvania | Anti-tumor endothelial marker-1 (TEM1) antibody variants and uses thereof |
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US9682143B2 (en) * | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
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KR20240033145A (en) | 2012-11-13 | 2024-03-12 | 비온테크 에스이 | Agents for treatment of claudin expressing cancer diseases |
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KR20150122761A (en) | 2013-02-26 | 2015-11-02 | 로슈 글리카트 아게 | Bispecific t cell activating antigen binding molecules |
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US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
MX366359B (en) | 2014-04-27 | 2019-07-05 | Ccam Biotherapeutics Ltd | Humanized antibodies against ceacam1. |
EP3164417A1 (en) | 2014-07-01 | 2017-05-10 | Pfizer Inc. | Bispecific heterodimeric diabodies and uses thereof |
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CN107849137B (en) | 2015-10-02 | 2021-11-26 | 豪夫迈·罗氏有限公司 | Bispecific anti-CEAXCD 3T cell activating antigen binding molecules |
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ES2837428T3 (en) | 2016-01-08 | 2021-06-30 | Hoffmann La Roche | CEA-Positive Cancer Treatment Procedures Using PD-1 Axis Binding Antagonists and Anti-CEA / Anti-CD3 Bispecific Antibodies |
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CN107663240B (en) * | 2016-07-29 | 2021-01-12 | 中国人民解放军第四军医大学 | Single-chain antibody specifically bound by highly glycosylated CEA and application thereof in detection and treatment |
TWI829628B (en) | 2016-12-19 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | Combination therapy with targeted 4-1bb (cd137) agonists |
TW201829469A (en) | 2017-01-03 | 2018-08-16 | 瑞士商赫孚孟拉羅股份公司 | Bispecific antigen binding molecules comprising anti-4-1bb clone 20h4.9 |
CN107056952A (en) * | 2017-05-10 | 2017-08-18 | 常州市第人民医院 | CEA.CAR T and its preparation and application |
CN107058234B (en) * | 2017-05-12 | 2019-09-13 | 常州市第一人民医院 | CAR.IL-33-T and its preparation and application |
KR20200041897A (en) | 2017-08-01 | 2020-04-22 | 에이비 스튜디오 인코포레이티드 | Bispecific antibodies and uses thereof |
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US20210221908A1 (en) | 2018-06-03 | 2021-07-22 | Lamkap Bio Beta Ltd. | Bispecific antibodies against ceacam5 and cd47 |
TW202035447A (en) | 2018-07-04 | 2020-10-01 | 瑞士商赫孚孟拉羅股份公司 | Novel bispecific agonistic 4-1bb antigen binding molecules |
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EP3693023A1 (en) | 2019-02-11 | 2020-08-12 | Sanofi | Use of anti-ceacam5 immunoconjugates for treating lung cancer |
MX2021009514A (en) | 2019-02-07 | 2021-11-04 | Sanofi Sa | Use of anti-ceacam5 immunoconjugates for treating lung cancer. |
WO2020232247A1 (en) | 2019-05-14 | 2020-11-19 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
AU2020291014A1 (en) | 2019-06-13 | 2022-01-27 | Bolt Biotherapeutics, Inc. | Aminobenzazepine compounds, immunoconjugates, and uses thereof |
EP3990492A1 (en) | 2019-06-27 | 2022-05-04 | F. Hoffmann-La Roche AG | Novel icos antibodies and tumor-targeted antigen binding molecules comprising them |
WO2021041300A2 (en) * | 2019-08-23 | 2021-03-04 | Ab Therapeutics, Inc. | Bispecific antibodies and uses thereof |
CN114630684A (en) | 2019-09-03 | 2022-06-14 | 博尔特生物治疗药物有限公司 | Aminoquinoline compounds, immunoconjugates and uses thereof |
CA3150265A1 (en) | 2019-09-18 | 2021-03-25 | Sara MAJOCCHI | Bispecific antibodies against ceacam5 and cd3 |
US20220347310A1 (en) | 2019-09-30 | 2022-11-03 | Bolt Biotherapeutics, Inc. | Amide-linked, aminobenzazepine immunoconjugates, and uses thereof |
WO2021081407A1 (en) | 2019-10-25 | 2021-04-29 | Bolt Biotherapeutics, Inc. | Thienoazepine immunoconjugates, and uses thereof |
TW202128765A (en) * | 2019-11-21 | 2021-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | A bispecific antibody |
EP3831849A1 (en) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
AR121706A1 (en) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | OX40 AND FAP-TARGETED BSPECIFIC ANTIGEN-BINDING MOLECULES |
US20230293716A1 (en) | 2020-05-08 | 2023-09-21 | Bolt Biotherapeutics, Inc. | Elastase-substrate, peptide linker immunoconjugates, and uses thereof |
CA3186059A1 (en) | 2020-08-13 | 2022-02-17 | Romas Kudirka | Pyrazoloazepine immunoconjugates, and uses thereof |
US20220195066A1 (en) | 2020-12-11 | 2022-06-23 | Bolt Biotherapeutics, Inc. | Anti-cea immunoconjugates, and uses thereof |
CA3200051A1 (en) | 2020-12-11 | 2022-06-16 | Shelley Erin ACKERMAN | Anti-cea immunoconjugates, and uses thereof |
US11753481B2 (en) | 2020-12-18 | 2023-09-12 | Lamkap Bio Beta Ltd | Bispecific antibodies against CEACAM5 and CD47 |
CA3212907A1 (en) | 2021-03-26 | 2022-09-29 | Gary Brandt | 2-amino-4-carboxamide-benzazepine immunoconjugates, and uses thereof |
CN117769439A (en) | 2021-03-26 | 2024-03-26 | 博尔特生物治疗药物有限公司 | 2-amino-4-carboxamide-benzazepine immunoconjugates and uses thereof |
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PL1976880T3 (en) | 2005-12-21 | 2017-01-31 | Amgen Research (Munich) Gmbh | Pharmaceutical compositions with resistance to soluble cea |
CA2633756C (en) * | 2005-12-21 | 2015-11-24 | Micromet Ag | Pharmaceutical antibody compositions with resistance to soluble cea |
-
2006
- 2006-12-21 PL PL06841112T patent/PL1976880T3/en unknown
- 2006-12-21 WO PCT/EP2006/012425 patent/WO2007071426A1/en active Application Filing
- 2006-12-21 JP JP2008546272A patent/JP5399712B2/en not_active Expired - Fee Related
- 2006-12-21 EP EP06841112.3A patent/EP1976880B1/en active Active
- 2006-12-21 EP EP12167996A patent/EP2527370A1/en not_active Withdrawn
- 2006-12-21 DK DK06841112.3T patent/DK1976880T3/en active
- 2006-12-21 RU RU2008129787/10A patent/RU2426743C2/en not_active IP Right Cessation
- 2006-12-21 HU HUE06841112A patent/HUE031151T2/en unknown
- 2006-12-21 AU AU2006328886A patent/AU2006328886C1/en not_active Ceased
- 2006-12-21 CN CN200680052637.9A patent/CN101370827B/en not_active Expired - Fee Related
- 2006-12-21 CA CA2633766A patent/CA2633766C/en not_active Expired - Fee Related
- 2006-12-21 RS RS20160791A patent/RS55181B1/en unknown
- 2006-12-21 NZ NZ569204A patent/NZ569204A/en not_active IP Right Cessation
- 2006-12-21 LT LTEP06841112.3T patent/LT1976880T/en unknown
- 2006-12-21 SG SG2013054853A patent/SG193141A1/en unknown
- 2006-12-21 PT PT68411123T patent/PT1976880T/en unknown
- 2006-12-21 ES ES06841112.3T patent/ES2595091T3/en active Active
- 2006-12-21 BR BRPI0620632-8A patent/BRPI0620632A2/en active Search and Examination
- 2006-12-21 US US12/158,611 patent/US8394926B2/en active Active
- 2006-12-21 KR KR1020087017796A patent/KR101287777B1/en active IP Right Grant
- 2006-12-21 ZA ZA200805400A patent/ZA200805400B/en unknown
-
2008
- 2008-06-18 IL IL192277A patent/IL192277A/en not_active IP Right Cessation
- 2008-10-22 HK HK08111613.6A patent/HK1115890A1/en not_active IP Right Cessation
-
2010
- 2010-11-29 RU RU2010148652/10A patent/RU2573893C2/en not_active IP Right Cessation
-
2012
- 2012-10-03 JP JP2012221161A patent/JP2013056885A/en not_active Withdrawn
-
2013
- 2013-01-14 US US13/740,358 patent/US9695250B2/en active Active
-
2016
- 2016-09-19 US US15/269,680 patent/US9982063B2/en active Active
- 2016-09-23 CY CY20161100951T patent/CY1118053T1/en unknown
- 2016-09-23 HR HRP20161216TT patent/HRP20161216T1/en unknown
- 2016-12-21 ME MEP-2016-218A patent/ME02581B/en unknown
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