PT1169054E - PRODUCTS AND METHODS FOR TREATING DISEASES RELATED TO PTP LAR - Google Patents

PRODUCTS AND METHODS FOR TREATING DISEASES RELATED TO PTP LAR

Info

Publication number
PT1169054E
PT1169054E PT00921845T PT00921845T PT1169054E PT 1169054 E PT1169054 E PT 1169054E PT 00921845 T PT00921845 T PT 00921845T PT 00921845 T PT00921845 T PT 00921845T PT 1169054 E PT1169054 E PT 1169054E
Authority
PT
Portugal
Prior art keywords
methods
products
ptp lar
treating diseases
diseases related
Prior art date
Application number
PT00921845T
Other languages
Portuguese (pt)
Inventor
Axel Ullrich
Thomas Muller
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Publication of PT1169054E publication Critical patent/PT1169054E/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)

Abstract

The present invention relates to methods and products useful for the treatment of various epithelial cell migration diseases and disorders, and to methods useful for the identification of various products useful for the treatment of these diseases and disorders. In particular, methods for treating using PTP LAR are described, as are methods for identifying compounds to modulate PTP LAR activity.
PT00921845T 1999-04-09 2000-04-06 PRODUCTS AND METHODS FOR TREATING DISEASES RELATED TO PTP LAR PT1169054E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12867399P 1999-04-09 1999-04-09

Publications (1)

Publication Number Publication Date
PT1169054E true PT1169054E (en) 2004-11-30

Family

ID=22436431

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00921845T PT1169054E (en) 1999-04-09 2000-04-06 PRODUCTS AND METHODS FOR TREATING DISEASES RELATED TO PTP LAR

Country Status (9)

Country Link
US (1) US20090074722A1 (en)
EP (1) EP1169054B1 (en)
JP (1) JP2002541214A (en)
AT (1) ATE272406T1 (en)
AU (1) AU4210900A (en)
CA (1) CA2365945A1 (en)
DE (1) DE60012718T2 (en)
PT (1) PT1169054E (en)
WO (1) WO2000061180A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4852046B2 (en) 2004-10-12 2012-01-11 クルセル ホランド ベー ヴェー Binding molecules for the treatment and detection of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040629A1 (en) * 1995-06-07 1996-12-19 Sugen, Inc. Tyrphostin-like compounds for the treatment of cell proliferative disorders or cell differentiation disorders
EP1014953B1 (en) * 1997-03-05 2012-04-25 Sugen, Inc. Formulations for hydrophobic pharmaceutical agents
JP2004500308A (en) * 1998-03-12 2004-01-08 ノボ　ノルディスク　アクティーゼルスカブ Modulator of protein tyrosine phosphatase

Also Published As

Publication number Publication date
EP1169054B1 (en) 2004-08-04
AU4210900A (en) 2000-11-14
EP1169054A2 (en) 2002-01-09
DE60012718D1 (en) 2004-09-09
JP2002541214A (en) 2002-12-03
WO2000061180A3 (en) 2001-06-28
DE60012718T2 (en) 2005-10-20
US20090074722A1 (en) 2009-03-19
WO2000061180A2 (en) 2000-10-19
CA2365945A1 (en) 2000-10-19
ATE272406T1 (en) 2004-08-15

Similar Documents

Publication Publication Date Title
ATE279181T1 (en) USE OF 5HT-6 ANTAGONISTS TO TREAT ADHD
BR0207811A (en) Substituted aryl and heteroaryl urea compounds useful in treating diseases
ATE402698T1 (en) USE OF PPAR-GAMMA ACTIVATORS TO TREAT SKIN DISEASES
DE59903921D1 (en) INDOLDER DERIVATIVES AND THE USE THEREOF FOR TREATING MALIGNAS AND OTHER DISEASES BASED ON PATHOLOGICAL CELL PROLIFERATIONS
BR0315688A (en) Compounds, pharmaceutical compositions and their uses in the treatment or prevention of diseases or conditions of metabolic cell proliferation
PT971713E (en) USE OF COLINESTERASE INHIBITORS FOR TREATMENT OF ATENTION DISORDERS
JO2373B1 (en) W-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinease Inhibitors
DE69826695D1 (en) ARYL URINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY OR IMMUNOMODULATORY DISEASES
DE60222302D1 (en) INHIBITORS OF MITOTIC KINESINE
EA200001258A1 (en) PYRRO-SUBSTITUTED 2-INDOLINONS (OPTIONS), PHARMACEUTICAL COMPOSITION (VARIANTS), METHOD FOR MODULATING PROTEINKINASE CATALYTIC ACTIVITY, METHOD FOR TREATING OR PROPHYLAXIS OF DISTURBANCE IN ORGANISMES OF PHYSICIANS, PREVENTION OR PREVENTION OF DISTURBANCE
ES2143611T3 (en) PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS METALOPROTEINASE INHIBITORS.
DE60037394D1 (en) USE OF p53 INHIBITORS FOR THE TREATMENT OF SIDE EFFECTS IN CANCER THERAPY
TR200500221T2 (en) Bicyclic Amino Acids as Pharmaceutical Substances
DE69626539D1 (en) topical use of vitamin D for the treatment of eye diseases
ATE350030T1 (en) NORDIHYDROGUAIARETIC ACID DERIVATIVES FOR THE TREATMENT OF TUMORS
ATE415962T1 (en) USE OF ASIATIC ACID OR ASIATICOSIDE TO TREAT CANCER
ATE260653T1 (en) USE OF NAALADASE INHIBITORS TO TREAT ANXIETY AND MEMORY DISORDERS
DE69918972D1 (en) USE OF NMDA ANTAGONISTS AND / OR SODIUM CHANNEL ANTAGONISTS FOR TREATING INFLAMMABLE DISEASES
EA200500934A1 (en) Compounds modulating the activity of the kinase protein of multiple lines and methods for the treatment of neurodegenerative and inflammatory diseases
ATE346147T1 (en) COMPOSITIONS AND METHODS OF WOUND HEALING
ATE287722T1 (en) AGENT FOR TREATING MALIGNANT DISEASES USING THE PROTEIN YB-1
ATE290857T1 (en) BRETYLIUM-CONTAINING COMPOSITIONS AND KITS AND THE USE THEREOF FOR PREVENTING AND TREATING CARDIOVASCULAR DISEASES
ATE313561T1 (en) VGF POLYPEPTIDES AND METHODS FOR TREATING VGF DISEASES
UY26265A1 (en) CALCIOLYTIC COMPOUNDS
ATE261724T1 (en) ANTICONVULSIVE DERIVATIVES FOR THE TREATMENT OF POST-TRAAUMATIC STRESS DISEASES