PT1066294E - NEW PROCESS FOR THE FERMENTATIVE PRODUCTION OF CEFALOSPORINA - Google Patents

NEW PROCESS FOR THE FERMENTATIVE PRODUCTION OF CEFALOSPORINA

Info

Publication number
PT1066294E
PT1066294E PT99915731T PT99915731T PT1066294E PT 1066294 E PT1066294 E PT 1066294E PT 99915731 T PT99915731 T PT 99915731T PT 99915731 T PT99915731 T PT 99915731T PT 1066294 E PT1066294 E PT 1066294E
Authority
PT
Portugal
Prior art keywords
mixture
complex mixture
adipyl
cefalosporina
general formula
Prior art date
Application number
PT99915731T
Other languages
Portuguese (pt)
Inventor
Ilco Adrianus Lambertu Boogers
Emilius Johannes Albertu Sandi
Dick Schipper
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Publication of PT1066294E publication Critical patent/PT1066294E/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/08—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin disubstituted in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/183—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing an indolo[4,3-F,G]quinoleine nucleus, e.g. compound containing the lysergic acid nucleus as well as the dimeric ergot nucleus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin

Abstract

A method for the recovery of an N-substituted cephalosporanic acid compound of general formula (I), wherein R2 is selected from the group consisting of adipyl (1,4-dicarboxybutane), succinyl, glutaryl, adipyl, pimelyl, suberyl, 2-carboxyethyithio)acetyl, 3-carboxyethylthio)propionyl, higher alkyl saturated and higher alkyl unsaturated dicarboxylic acids, from a complex mixture comprising in addition to the compound of general formula (I) 6-aminopenicillanic acid (6-APA) and optionally one or more N-substituted penicillanic acid compounds, comprising the steps of: (a) acidifying the complex mixture to a pH below 6.5 and maintaining the mixture below said pH at a temperature of between 10° C. and 150° C.; and/or (b) contacting the complex mixture with a carbon dioxide source; and (c) recovering the cephalosporanic acid compound of formula (I) from the mixture obtained after steps (a) and/or (b).
PT99915731T 1998-03-27 1999-03-26 NEW PROCESS FOR THE FERMENTATIVE PRODUCTION OF CEFALOSPORINA PT1066294E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98201011 1998-03-27

Publications (1)

Publication Number Publication Date
PT1066294E true PT1066294E (en) 2003-03-31

Family

ID=8233541

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99915731T PT1066294E (en) 1998-03-27 1999-03-26 NEW PROCESS FOR THE FERMENTATIVE PRODUCTION OF CEFALOSPORINA

Country Status (17)

Country Link
US (2) US6552185B1 (en)
EP (1) EP1066294B1 (en)
JP (1) JP2002509933A (en)
KR (1) KR100594774B1 (en)
CN (1) CN1138781C (en)
AT (1) ATE226954T1 (en)
AU (1) AU3419399A (en)
BR (1) BR9909108A (en)
DE (1) DE69903719T2 (en)
ES (1) ES2186347T3 (en)
ID (1) ID26888A (en)
PL (1) PL343099A1 (en)
PT (1) PT1066294E (en)
RU (1) RU2219182C2 (en)
SI (1) SI1066294T1 (en)
WO (1) WO1999050271A1 (en)
ZA (1) ZA200004801B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3419399A (en) * 1998-03-27 1999-10-18 Dsm N.V. Novel process for the fermentative production of cephalosporin
WO2001023393A1 (en) * 1999-09-30 2001-04-05 Otsuka Kagaku Kabushiki Kaisha 3-cephem derivative crystal and method for preparing the same
JP2002316991A (en) * 2001-04-18 2002-10-31 Otsuka Chem Co Ltd Penicillin and cephalosporin compound
CN1912130B (en) * 2005-08-08 2011-06-15 百瑞全球有限公司 Two-step enzyme method for preparing 7-aminocephalosporanic acid
EP2614066B1 (en) * 2010-09-07 2017-11-29 DSM Sinochem Pharmaceuticals Netherlands B.V. Process for the production of cephalosporins
EP3666074A1 (en) * 2018-12-16 2020-06-17 Sandoz GmbH Adjuvant composition, method of producing the adjuvant composi-tion and uses thereof
CN112625053B (en) * 2020-12-30 2022-08-09 伊犁川宁生物技术股份有限公司 7-ACA with low content of maximum unknown simple impurity and preparation method thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE465649A (en) * 1944-06-19
GB810196A (en) * 1955-02-02 1959-03-11 Nat Res Dev Cephalosporin c
GB1272769A (en) * 1968-08-02 1972-05-03 Glaxo Lab Ltd Improvements in or relating to cephalosporin derivatives
FR2404642A1 (en) * 1977-09-29 1979-04-27 Roussel Uclaf NEW DERIVATIVE OF CEPHALOSPORIN C, PROCESS FOR PREPARATION AND APPLICATION OF THE NEW PRODUCT TO THE PREPARATION OF 7-AMINO CEPHALOSPORANIC ACID
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
WO1993008287A1 (en) 1991-10-15 1993-04-29 Merck & Co., Inc. Novel bioprocesses for preparing 7-aca and 7-adac
CZ285604B6 (en) 1993-07-30 1999-09-15 Gist-Brocades B. V. Process for preparing and isolation of 7-aminodesacetoxycephalosporanic acid
BE1009070A3 (en) * 1995-02-02 1996-11-05 Dsm Nv PROCESS FOR THE EXTRACTION OF A beta-lactam drug.
AU3661597A (en) * 1996-07-29 1998-02-20 Bristol-Myers Squibb Company Solvent extraction of 3-hydroxymethylcephalosporins
BE1010651A3 (en) * 1996-09-27 1998-11-03 Dsm Nv Process for the purification of cefalexin.
WO1998048036A1 (en) 1997-04-22 1998-10-29 Gist-Brocades B.V. Improved process for the fermentative production of cephalosporin
AU3419399A (en) * 1998-03-27 1999-10-18 Dsm N.V. Novel process for the fermentative production of cephalosporin

Also Published As

Publication number Publication date
US6803460B2 (en) 2004-10-12
DE69903719T2 (en) 2003-09-18
ID26888A (en) 2001-02-15
DE69903719D1 (en) 2002-12-05
CN1295575A (en) 2001-05-16
EP1066294A1 (en) 2001-01-10
US20030139595A1 (en) 2003-07-24
ES2186347T3 (en) 2003-05-01
PL343099A1 (en) 2001-07-30
US6552185B1 (en) 2003-04-22
AU3419399A (en) 1999-10-18
WO1999050271A1 (en) 1999-10-07
KR20010034700A (en) 2001-04-25
BR9909108A (en) 2000-12-12
RU2219182C2 (en) 2003-12-20
SI1066294T1 (en) 2003-04-30
KR100594774B1 (en) 2006-07-03
ZA200004801B (en) 2001-07-25
JP2002509933A (en) 2002-04-02
ATE226954T1 (en) 2002-11-15
CN1138781C (en) 2004-02-18
EP1066294B1 (en) 2002-10-30

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